Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36435 http://dx.doi.org/10.3748/wjg.v19.i24.3723 |
Resumo: | Ochratoxin A (OTA) is a secondary metabolite of Aspergillus and Penicillium, microorganisms that can be hazardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular carcinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. in a recent study, Ibrahim et al proposed a correlation between the incidence of HCC and contamination with OTA. Analysis of OTA in serum samples showed that HCC patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in HCC patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods. (C) 2013 Baishideng. All rights reserved. |
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Felizardo, Raphael José Ferreira [UNIFESP]Câmara, Niels Olsen Saraiva [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T14:31:53Z2016-01-24T14:31:53Z2013-06-28World Journal of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 19, n. 24, p. 3723-3725, 2013.1007-9327http://repositorio.unifesp.br/handle/11600/36435http://dx.doi.org/10.3748/wjg.v19.i24.372310.3748/wjg.v19.i24.3723WOS:000321115100002Ochratoxin A (OTA) is a secondary metabolite of Aspergillus and Penicillium, microorganisms that can be hazardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular carcinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. in a recent study, Ibrahim et al proposed a correlation between the incidence of HCC and contamination with OTA. Analysis of OTA in serum samples showed that HCC patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in HCC patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods. (C) 2013 Baishideng. All rights reserved.Universidade Federal de São Paulo, Dept Med, Div Nephrol, BR-05508900 São Paulo, BrazilUniv São Paulo, Inst Biomed Sci, Dept Immunol, BR-05508900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Nephrol, BR-05508900 São Paulo, BrazilWeb of Science3723-3725engBaishideng Publ Grp Co LtdWorld Journal of GastroenterologyOchratoxin AMycotoxinFood contaminationHepatocellular carcinomaLiver cancerEgyptHepatocellular carcinoma and food contamination: Ochratoxin A as a great prompterinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/364352022-09-27 11:31:15.869metadata only accessoai:repositorio.unifesp.br:11600/36435Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-09-27T14:31:15Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter |
title |
Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter |
spellingShingle |
Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter Felizardo, Raphael José Ferreira [UNIFESP] Ochratoxin A Mycotoxin Food contamination Hepatocellular carcinoma Liver cancer Egypt |
title_short |
Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter |
title_full |
Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter |
title_fullStr |
Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter |
title_full_unstemmed |
Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter |
title_sort |
Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter |
author |
Felizardo, Raphael José Ferreira [UNIFESP] |
author_facet |
Felizardo, Raphael José Ferreira [UNIFESP] Câmara, Niels Olsen Saraiva [UNIFESP] |
author_role |
author |
author2 |
Câmara, Niels Olsen Saraiva [UNIFESP] |
author2_role |
author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Felizardo, Raphael José Ferreira [UNIFESP] Câmara, Niels Olsen Saraiva [UNIFESP] |
dc.subject.eng.fl_str_mv |
Ochratoxin A Mycotoxin Food contamination Hepatocellular carcinoma Liver cancer Egypt |
topic |
Ochratoxin A Mycotoxin Food contamination Hepatocellular carcinoma Liver cancer Egypt |
description |
Ochratoxin A (OTA) is a secondary metabolite of Aspergillus and Penicillium, microorganisms that can be hazardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular carcinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. in a recent study, Ibrahim et al proposed a correlation between the incidence of HCC and contamination with OTA. Analysis of OTA in serum samples showed that HCC patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in HCC patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods. (C) 2013 Baishideng. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-06-28 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:53Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
World Journal of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 19, n. 24, p. 3723-3725, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36435 http://dx.doi.org/10.3748/wjg.v19.i24.3723 |
dc.identifier.issn.none.fl_str_mv |
1007-9327 |
dc.identifier.doi.none.fl_str_mv |
10.3748/wjg.v19.i24.3723 |
dc.identifier.wos.none.fl_str_mv |
WOS:000321115100002 |
identifier_str_mv |
World Journal of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 19, n. 24, p. 3723-3725, 2013. 1007-9327 10.3748/wjg.v19.i24.3723 WOS:000321115100002 |
url |
http://repositorio.unifesp.br/handle/11600/36435 http://dx.doi.org/10.3748/wjg.v19.i24.3723 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
World Journal of Gastroenterology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3723-3725 |
dc.publisher.none.fl_str_mv |
Baishideng Publ Grp Co Ltd |
publisher.none.fl_str_mv |
Baishideng Publ Grp Co Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764172159614976 |