Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/28855 http://dx.doi.org/10.1038/sj.ki.5000311 |
Resumo: | Osteoporosis in hemodialysis patients is associated with high morbidity and mortality and, although extensively studied by noninvasive methods, has never been assessed through bone biopsy. the aim of this study was to use histomorphometry to evaluate osteoporosis and identify factors related to its development in hemodialysis patients. We conducted a cross-sectional study involving 98 patients ( 35 women and 63 men; mean age: 48.4 +/- 13 years) on hemodialysis for 36.9 +/- 24.7 months. Patients were submitted to transiliac bone biopsy with double tetracycline labeling. the bone metabolism factors ionized calcium, phosphorus, bone alkaline phosphatase, deoxypyridinoline, intact parathyroid hormone, and 25( OH) vitamin D were evaluated, as were the bone remodeling cytokines osteoprotegerin (OPG), soluble receptor-activator of NF-kappa beta ligand (sRANKL) and tumor necrosis factor-alpha (TNF)alpha. Osteoporosis was defined as trabecular bone volume ( BV/ TV) greater than 1 s.d. below normal ( men < 17.4%; women < 14.7%). Forty-five patients (46%) presented osteoporosis, which was correlated with white race. We found BV/ TV to correlate with age, OPG/sRANKL ratio, TNF alpha levels, and length of amenorrhea. in multiple regression analysis adjusted for sex and age, length of amenorrhea, white race, and OPG/ sRANKL ratio were independent determinants of BV/TV. Histomorphometric analysis demonstrated that osteoporotic patients presented normal eroded surface and low bone formation rate (BFR/BS). Osteoporosis is prevalent in hemodialysis patients. Low BFR/BS could be involved in its development, even when bone resorption is normal. Cytokines may also play a role as may traditional risk factors such as advanced age, hypogonadism, and white race. |
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Barreto, Fellype Carvalho [UNIFESP]Barreto, Daniela VeitMoysés, Rosa Maria AffonsoNeves, C. L.Jorgetti, VandaDraibe, Sergio Antonio [UNIFESP]Canziani, Maria Eugenia [UNIFESP]Carvalho, A. B.Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T12:41:07Z2016-01-24T12:41:07Z2006-05-01Kidney International. New York: Nature Publishing Group, v. 69, n. 10, p. 1852-1857, 2006.0085-2538http://repositorio.unifesp.br/handle/11600/28855http://dx.doi.org/10.1038/sj.ki.500031110.1038/sj.ki.5000311WOS:000237673800030Osteoporosis in hemodialysis patients is associated with high morbidity and mortality and, although extensively studied by noninvasive methods, has never been assessed through bone biopsy. the aim of this study was to use histomorphometry to evaluate osteoporosis and identify factors related to its development in hemodialysis patients. We conducted a cross-sectional study involving 98 patients ( 35 women and 63 men; mean age: 48.4 +/- 13 years) on hemodialysis for 36.9 +/- 24.7 months. Patients were submitted to transiliac bone biopsy with double tetracycline labeling. the bone metabolism factors ionized calcium, phosphorus, bone alkaline phosphatase, deoxypyridinoline, intact parathyroid hormone, and 25( OH) vitamin D were evaluated, as were the bone remodeling cytokines osteoprotegerin (OPG), soluble receptor-activator of NF-kappa beta ligand (sRANKL) and tumor necrosis factor-alpha (TNF)alpha. Osteoporosis was defined as trabecular bone volume ( BV/ TV) greater than 1 s.d. below normal ( men < 17.4%; women < 14.7%). Forty-five patients (46%) presented osteoporosis, which was correlated with white race. We found BV/ TV to correlate with age, OPG/sRANKL ratio, TNF alpha levels, and length of amenorrhea. in multiple regression analysis adjusted for sex and age, length of amenorrhea, white race, and OPG/ sRANKL ratio were independent determinants of BV/TV. Histomorphometric analysis demonstrated that osteoporotic patients presented normal eroded surface and low bone formation rate (BFR/BS). Osteoporosis is prevalent in hemodialysis patients. Low BFR/BS could be involved in its development, even when bone resorption is normal. Cytokines may also play a role as may traditional risk factors such as advanced age, hypogonadism, and white race.Universidade Federal de São Paulo, Dept Internal Med, Div Nephrol, BR-04038002 São Paulo, BrazilUniv São Paulo, Div Nephrol, Dept Internal Med, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Internal Med, Div Nephrol, BR-04038002 São Paulo, BrazilWeb of Science1852-1857engNature Publishing GroupKidney Internationalbone diseasesmetabolicosteoporosisdialysisbone histomorphometryOsteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old probleminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/288552023-01-30 22:17:46.14metadata only accessoai:repositorio.unifesp.br:11600/28855Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:44:36.861899Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem |
title |
Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem |
spellingShingle |
Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem Barreto, Fellype Carvalho [UNIFESP] bone diseases metabolic osteoporosis dialysis bone histomorphometry |
title_short |
Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem |
title_full |
Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem |
title_fullStr |
Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem |
title_full_unstemmed |
Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem |
title_sort |
Osteoporosis in hemodialysis patients revisited by bone histomorphometry: A new insight into an old problem |
author |
Barreto, Fellype Carvalho [UNIFESP] |
author_facet |
Barreto, Fellype Carvalho [UNIFESP] Barreto, Daniela Veit Moysés, Rosa Maria Affonso Neves, C. L. Jorgetti, Vanda Draibe, Sergio Antonio [UNIFESP] Canziani, Maria Eugenia [UNIFESP] Carvalho, A. B. |
author_role |
author |
author2 |
Barreto, Daniela Veit Moysés, Rosa Maria Affonso Neves, C. L. Jorgetti, Vanda Draibe, Sergio Antonio [UNIFESP] Canziani, Maria Eugenia [UNIFESP] Carvalho, A. B. |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Barreto, Fellype Carvalho [UNIFESP] Barreto, Daniela Veit Moysés, Rosa Maria Affonso Neves, C. L. Jorgetti, Vanda Draibe, Sergio Antonio [UNIFESP] Canziani, Maria Eugenia [UNIFESP] Carvalho, A. B. |
dc.subject.eng.fl_str_mv |
bone diseases metabolic osteoporosis dialysis bone histomorphometry |
topic |
bone diseases metabolic osteoporosis dialysis bone histomorphometry |
description |
Osteoporosis in hemodialysis patients is associated with high morbidity and mortality and, although extensively studied by noninvasive methods, has never been assessed through bone biopsy. the aim of this study was to use histomorphometry to evaluate osteoporosis and identify factors related to its development in hemodialysis patients. We conducted a cross-sectional study involving 98 patients ( 35 women and 63 men; mean age: 48.4 +/- 13 years) on hemodialysis for 36.9 +/- 24.7 months. Patients were submitted to transiliac bone biopsy with double tetracycline labeling. the bone metabolism factors ionized calcium, phosphorus, bone alkaline phosphatase, deoxypyridinoline, intact parathyroid hormone, and 25( OH) vitamin D were evaluated, as were the bone remodeling cytokines osteoprotegerin (OPG), soluble receptor-activator of NF-kappa beta ligand (sRANKL) and tumor necrosis factor-alpha (TNF)alpha. Osteoporosis was defined as trabecular bone volume ( BV/ TV) greater than 1 s.d. below normal ( men < 17.4%; women < 14.7%). Forty-five patients (46%) presented osteoporosis, which was correlated with white race. We found BV/ TV to correlate with age, OPG/sRANKL ratio, TNF alpha levels, and length of amenorrhea. in multiple regression analysis adjusted for sex and age, length of amenorrhea, white race, and OPG/ sRANKL ratio were independent determinants of BV/TV. Histomorphometric analysis demonstrated that osteoporotic patients presented normal eroded surface and low bone formation rate (BFR/BS). Osteoporosis is prevalent in hemodialysis patients. Low BFR/BS could be involved in its development, even when bone resorption is normal. Cytokines may also play a role as may traditional risk factors such as advanced age, hypogonadism, and white race. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-05-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:41:07Z |
dc.date.available.fl_str_mv |
2016-01-24T12:41:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Kidney International. New York: Nature Publishing Group, v. 69, n. 10, p. 1852-1857, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/28855 http://dx.doi.org/10.1038/sj.ki.5000311 |
dc.identifier.issn.none.fl_str_mv |
0085-2538 |
dc.identifier.doi.none.fl_str_mv |
10.1038/sj.ki.5000311 |
dc.identifier.wos.none.fl_str_mv |
WOS:000237673800030 |
identifier_str_mv |
Kidney International. New York: Nature Publishing Group, v. 69, n. 10, p. 1852-1857, 2006. 0085-2538 10.1038/sj.ki.5000311 WOS:000237673800030 |
url |
http://repositorio.unifesp.br/handle/11600/28855 http://dx.doi.org/10.1038/sj.ki.5000311 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Kidney International |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1852-1857 |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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