Estudo iWONDER (Imaging WhOle vessel coroNary tree with intravascular ultrasounD and iMap® in patiEnts with acute myocaRdial infarction): racional e desenho do estudo

• Autor(a) principal: Souza, Cristiano Freitas de [UNIFESP]
• Data de Publicação: 2012
• Outros Autores: Alves, Claudia Maria Rodrigues [UNIFESP], Carvalho, Antonio Carlos [UNIFESP], Bonfim, Alexandre Vidal [UNIFESP], Silva, Erlon Oliveira de Abreu [UNIFESP], Pereira Júnior, Edilberto Castilho [UNIFESP], Falcão, Felipe José de Andrade [UNIFESP], Lanaro, Eduardo [UNIFESP], Barbosa, Adriano Henrique Pereira [UNIFESP], Souza, José Augusto Marcondes de [UNIFESP], Sousa, José Marconi A. [UNIFESP], Souza, Rodrigo Almeida [UNIFESP], Rigla, Juan, Caixeta, Adriano [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/00130000013s1
• Texto Completo: http://dx.doi.org/10.1590/S2179-83972012000200015; http://repositorio.unifesp.br/handle/11600/7182
• topic: Coronary artery disease; Acute coronary syndrome; Ultrassonography; Doença da artéria coronária; Síndrome coronária aguda; Ultrassonografia

BACKGROUND: Intravascular ultrasound (IVUS) provides a sensitive and reproducible measurement of coronary artery dimensions, atherosclerotic plaque, and arterial lumen. Advances in IVUS technology now allow the characterization of the composition and morphology of atherosclerotic plaques. Although previous studies have reported data using IVUS radiofrequency analysis, the use of a new modality (iMap®, Boston Scientific, Santa Clara, USA) of atherosclerotic plaque characterization is very little known. Our objective is to analyze the morphological, phenotypic and tissue characteristics of culprit and non-culprit atherosclerotic plaques determined by angiography in patients undergoing coronary angiography due to acute myocardial infarction (AMI). METHODS: Prospective, cross-sectional, single center study (Hospital São Paulo - Escola Paulista de Medicina - Universidade Federal de São Paulo (UNIFESP)/UNIFESP, São Paulo, SP, Brazil). Fifty patients will be selected for ultrasound analysis according to the following inclusion criteria: age < 75 years, non-ST-segment elevation AMI or recent ST-segment elevation AMI, with or without previous fribrinolytic agents. CONCLUSIONS: The present study is aimed at obtaining morphological, phenotypic and tissue characteristics of the atherosclerotic plate using an imaging modality not extensively evaluated in patients with AMI.