Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/3992 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016 |
Resumo: | The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies. |
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Saraiva, Roberto Magalhães [UNIFESP]Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]Antonio, Ednei Luiz [UNIFESP]Campos Filho, Orlando [UNIFESP]Tucci, Paulo José Ferreira [UNIFESP]Moisés, Valdir Ambrósio [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:37:11Z2015-06-14T13:37:11Z2007-11-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 11, p. 1557-1565, 2007.0100-879Xhttp://repositorio.unifesp.br/handle/11600/3992http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016S0100-879X2007001100016.pdfS0100-879X200700110001610.1590/S0100-879X2006005000178WOS:000250175400016The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de MedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Fisiologia Cardiovascular e RespiratóriaUNIFESP, EPM, Depto. de MedicinaUNIFESP, EPM, Disciplina de Fisiologia Cardiovascular e RespiratóriaSciELO1557-1565engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchHeart failureMyocardial infarctionEchocardiographyHemodynamicsRats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarctioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2007001100016.pdfapplication/pdf1722969${dspace.ui.url}/bitstream/11600/3992/1/S0100-879X2007001100016.pdfd4675a178e9c39c4743c9541d012fe24MD51open accessTEXTS0100-879X2007001100016.pdf.txtS0100-879X2007001100016.pdf.txtExtracted texttext/plain34526${dspace.ui.url}/bitstream/11600/3992/2/S0100-879X2007001100016.pdf.txt2e78dc029312bd28abdccfef2b1373faMD52open access11600/39922021-09-30 17:25:18.259open accessoai:repositorio.unifesp.br:11600/3992Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:23:42.502667Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
title |
Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
spellingShingle |
Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction Saraiva, Roberto Magalhães [UNIFESP] Heart failure Myocardial infarction Echocardiography Hemodynamics |
title_short |
Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
title_full |
Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
title_fullStr |
Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
title_full_unstemmed |
Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
title_sort |
Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
author |
Saraiva, Roberto Magalhães [UNIFESP] |
author_facet |
Saraiva, Roberto Magalhães [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Campos Filho, Orlando [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] Moisés, Valdir Ambrósio [UNIFESP] |
author_role |
author |
author2 |
Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Campos Filho, Orlando [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] Moisés, Valdir Ambrósio [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Saraiva, Roberto Magalhães [UNIFESP] Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Campos Filho, Orlando [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] Moisés, Valdir Ambrósio [UNIFESP] |
dc.subject.eng.fl_str_mv |
Heart failure Myocardial infarction Echocardiography Hemodynamics |
topic |
Heart failure Myocardial infarction Echocardiography Hemodynamics |
description |
The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-11-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:37:11Z |
dc.date.available.fl_str_mv |
2015-06-14T13:37:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 11, p. 1557-1565, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/3992 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2007001100016.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2007001100016 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2006005000178 |
dc.identifier.wos.none.fl_str_mv |
WOS:000250175400016 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 11, p. 1557-1565, 2007. 0100-879X S0100-879X2007001100016.pdf S0100-879X2007001100016 10.1590/S0100-879X2006005000178 WOS:000250175400016 |
url |
http://repositorio.unifesp.br/handle/11600/3992 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
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1557-1565 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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