Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/27266 http://dx.doi.org/10.1590/S0004-282X2003000200031 |
Resumo: | Since the first report addressing quantification of cerebral blood flow (CBF), concomitant assessment of cerebral oxygen consumption was also carried out. Over the years, however, some investigators have emphatically and mistakenly addressed cerebral ischemia in comatose patients, on the basis of CBF measurements alone. in contrast, we have repeatedly reported that ischemia in these patients must be precisely evaluated based on CBF-metabolism coupling or uncoupling, rather than CBF alone. Based on these previous findings, we therefore propose a comprehensive alternative approach, namely the evaluation of brain ischemia in comatose patients based on cerebral metabolic parameters, such as cerebral extraction of oxygen or cerebral lactate release, without expensive CBF measurements. |
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Cruz, Julio [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:33:52Z2016-01-24T12:33:52Z2003-06-01Arquivos de Neuro-psiquiatria. São Paulo, SP: Assoc Arquivos de Neuro- Psiquiatria, v. 61, n. 2A, p. 309-312, 2003.0004-282Xhttp://repositorio.unifesp.br/handle/11600/27266http://dx.doi.org/10.1590/S0004-282X2003000200031S0004-282X2003000200031.pdfS0004-282X200300020003110.1590/S0004-282X2003000200031WOS:000183447700031Since the first report addressing quantification of cerebral blood flow (CBF), concomitant assessment of cerebral oxygen consumption was also carried out. Over the years, however, some investigators have emphatically and mistakenly addressed cerebral ischemia in comatose patients, on the basis of CBF measurements alone. in contrast, we have repeatedly reported that ischemia in these patients must be precisely evaluated based on CBF-metabolism coupling or uncoupling, rather than CBF alone. Based on these previous findings, we therefore propose a comprehensive alternative approach, namely the evaluation of brain ischemia in comatose patients based on cerebral metabolic parameters, such as cerebral extraction of oxygen or cerebral lactate release, without expensive CBF measurements.Universidade Federal de São Paulo, Escola Paulista Med, Comprehens Int Ctr Neuroemergencies, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Comprehens Int Ctr Neuroemergencies, São Paulo, SP, BrazilWeb of Science309-312engAssoc Arquivos de Neuro- PsiquiatriaArquivos de Neuro-psiquiatriaarteriojugular lactate differencebrain ischemiacerebral blood flowcerebral extraction of oxygencomaExpensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternativeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0004-282X2003000200031.pdfapplication/pdf58488${dspace.ui.url}/bitstream/11600/27266/1/S0004-282X2003000200031.pdff4fe29e32b0da64f019c5122be0d5b17MD51open access11600/272662022-07-08 10:29:00.57open accessoai:repositorio.unifesp.br:11600/27266Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-07-08T13:29Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative |
title |
Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative |
spellingShingle |
Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative Cruz, Julio [UNIFESP] arteriojugular lactate difference brain ischemia cerebral blood flow cerebral extraction of oxygen coma |
title_short |
Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative |
title_full |
Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative |
title_fullStr |
Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative |
title_full_unstemmed |
Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative |
title_sort |
Expensive cerebral blood flow measurements alone are useless and misinformative in comatose patients: A comprehensive alternative |
author |
Cruz, Julio [UNIFESP] |
author_facet |
Cruz, Julio [UNIFESP] |
author_role |
author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Cruz, Julio [UNIFESP] |
dc.subject.eng.fl_str_mv |
arteriojugular lactate difference brain ischemia cerebral blood flow cerebral extraction of oxygen coma |
topic |
arteriojugular lactate difference brain ischemia cerebral blood flow cerebral extraction of oxygen coma |
description |
Since the first report addressing quantification of cerebral blood flow (CBF), concomitant assessment of cerebral oxygen consumption was also carried out. Over the years, however, some investigators have emphatically and mistakenly addressed cerebral ischemia in comatose patients, on the basis of CBF measurements alone. in contrast, we have repeatedly reported that ischemia in these patients must be precisely evaluated based on CBF-metabolism coupling or uncoupling, rather than CBF alone. Based on these previous findings, we therefore propose a comprehensive alternative approach, namely the evaluation of brain ischemia in comatose patients based on cerebral metabolic parameters, such as cerebral extraction of oxygen or cerebral lactate release, without expensive CBF measurements. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003-06-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:33:52Z |
dc.date.available.fl_str_mv |
2016-01-24T12:33:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Arquivos de Neuro-psiquiatria. São Paulo, SP: Assoc Arquivos de Neuro- Psiquiatria, v. 61, n. 2A, p. 309-312, 2003. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/27266 http://dx.doi.org/10.1590/S0004-282X2003000200031 |
dc.identifier.issn.none.fl_str_mv |
0004-282X |
dc.identifier.file.none.fl_str_mv |
S0004-282X2003000200031.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0004-282X2003000200031 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0004-282X2003000200031 |
dc.identifier.wos.none.fl_str_mv |
WOS:000183447700031 |
identifier_str_mv |
Arquivos de Neuro-psiquiatria. São Paulo, SP: Assoc Arquivos de Neuro- Psiquiatria, v. 61, n. 2A, p. 309-312, 2003. 0004-282X S0004-282X2003000200031.pdf S0004-282X2003000200031 10.1590/S0004-282X2003000200031 WOS:000183447700031 |
url |
http://repositorio.unifesp.br/handle/11600/27266 http://dx.doi.org/10.1590/S0004-282X2003000200031 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Arquivos de Neuro-psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
309-312 |
dc.publisher.none.fl_str_mv |
Assoc Arquivos de Neuro- Psiquiatria |
publisher.none.fl_str_mv |
Assoc Arquivos de Neuro- Psiquiatria |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
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repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
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