A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/4984 http://dx.doi.org/10.1590/S1677-55382009000200011 |
Resumo: | INTRODUCTION: The appendix is the gold-standard channel for the Mitrofanoff principle in pediatric urology, but the search for alternatives is justified considering it may not be available or preferably used for colonic stomas (Malone antegrade continence enema). The aim of this study is to report on technical feasibility of a new approach for creating catheterizable channels in a rabbit model and to present our preliminary clinical experience. MATERIAL AND METHODS: We configured a tube from two rectangular skin flaps 1x4 cm opposite each other in the middle line of the lower inferior abdomen. The channel was anastomosed to the bladder dome with embedding sutures to create a valvular mechanism. The experimental study consisted of 12 rabbits, divided in 4 groups according to the sacrifice schedule at 2, 4, 8 and 12 weeks. At 30th postoperative day, an urodynamic evaluation was performed to record continence of the stoma. A histological analysis of the specimens stained with hematoxylin-eosin, Masson trichrome and Picrosirius red was also done in group 2 (sacrifice at 4 weeks postoperatively). We used this method in 3 patients with congenital non-neurogenic bladder disease presenting with massive residual volumes without compliance deficits. RESULT: The technique proved feasible in all animals, 9 of 12 could be easily catheterized and underwent urodynamic study. No stoma leakage was observed in 7 animals at high bladder pressures (> 50 cm H20) and only 2 animals had some leakage at 40 cm H20. Urodynamics performed through the stoma showed urethral leakage at 20 cm H20, therefore demonstrating the efficacy of the valvular mechanism. Histological analysis confirmed good integration between the tube and the bladder. Mean follow-up of the clinical series (3 patients) was 7.2 months. Two patients remained continent up to 4 hours, whereas 1 patient had some leakage after 2 hours. CONCLUSION: We were able to confirm feasibility of a new extra-abdominal channel based on the Mitrofanoff principle and successfully reproduced the method in a clinical setting. Follow-up was short and long term results are required before any conclusive judgment can be made. |
id |
UFSP_c3b1c23aaab209d1ba16c536dd1cb5cc |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/4984 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Macedo Jr., Antonio [UNIFESP]Rosito, Tiago [UNIFESP]Pires, Jesus A. S. [UNIFESP]Liguori, Riberto [UNIFESP]Ortiz, Valdemar [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:39:10Z2015-06-14T13:39:10Z2009-04-01International braz j urol. Sociedade Brasileira de Urologia, v. 35, n. 2, p. 205-216, 2009.1677-5538http://repositorio.unifesp.br/handle/11600/4984http://dx.doi.org/10.1590/S1677-55382009000200011S1677-55382009000200011.pdfS1677-5538200900020001110.1590/S1677-55382009000200011WOS:000283286900027INTRODUCTION: The appendix is the gold-standard channel for the Mitrofanoff principle in pediatric urology, but the search for alternatives is justified considering it may not be available or preferably used for colonic stomas (Malone antegrade continence enema). The aim of this study is to report on technical feasibility of a new approach for creating catheterizable channels in a rabbit model and to present our preliminary clinical experience. MATERIAL AND METHODS: We configured a tube from two rectangular skin flaps 1x4 cm opposite each other in the middle line of the lower inferior abdomen. The channel was anastomosed to the bladder dome with embedding sutures to create a valvular mechanism. The experimental study consisted of 12 rabbits, divided in 4 groups according to the sacrifice schedule at 2, 4, 8 and 12 weeks. At 30th postoperative day, an urodynamic evaluation was performed to record continence of the stoma. A histological analysis of the specimens stained with hematoxylin-eosin, Masson trichrome and Picrosirius red was also done in group 2 (sacrifice at 4 weeks postoperatively). We used this method in 3 patients with congenital non-neurogenic bladder disease presenting with massive residual volumes without compliance deficits. RESULT: The technique proved feasible in all animals, 9 of 12 could be easily catheterized and underwent urodynamic study. No stoma leakage was observed in 7 animals at high bladder pressures (> 50 cm H20) and only 2 animals had some leakage at 40 cm H20. Urodynamics performed through the stoma showed urethral leakage at 20 cm H20, therefore demonstrating the efficacy of the valvular mechanism. Histological analysis confirmed good integration between the tube and the bladder. Mean follow-up of the clinical series (3 patients) was 7.2 months. Two patients remained continent up to 4 hours, whereas 1 patient had some leakage after 2 hours. CONCLUSION: We were able to confirm feasibility of a new extra-abdominal channel based on the Mitrofanoff principle and successfully reproduced the method in a clinical setting. Follow-up was short and long term results are required before any conclusive judgment can be made.Federal University of São Paulo Department of UrologyUNIFESP, Department of UrologySciELO205-216engSociedade Brasileira de UrologiaInternational braz j urolbladderChildrenurinary diversionMitrofanoff principlesurgeryA new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experienceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1677-55382009000200011.pdfapplication/pdf916549${dspace.ui.url}/bitstream/11600/4984/1/S1677-55382009000200011.pdfb2dd8e9ccb685e7b325b6eb6f94563efMD51open accessTEXTS1677-55382009000200011.pdf.txtS1677-55382009000200011.pdf.txtExtracted texttext/plain27711${dspace.ui.url}/bitstream/11600/4984/2/S1677-55382009000200011.pdf.txt03516570f554188f9860a53b624f3036MD52open access11600/49842023-02-15 11:04:58.272open accessoai:repositorio.unifesp.br:11600/4984Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-02-15T14:04:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience |
title |
A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience |
spellingShingle |
A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience Macedo Jr., Antonio [UNIFESP] bladder Children urinary diversion Mitrofanoff principle surgery |
title_short |
A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience |
title_full |
A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience |
title_fullStr |
A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience |
title_full_unstemmed |
A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience |
title_sort |
A new extra-abdominal channel alternative to the mitrofanoff principle: experimental and preliminary clinical experience |
author |
Macedo Jr., Antonio [UNIFESP] |
author_facet |
Macedo Jr., Antonio [UNIFESP] Rosito, Tiago [UNIFESP] Pires, Jesus A. S. [UNIFESP] Liguori, Riberto [UNIFESP] Ortiz, Valdemar [UNIFESP] |
author_role |
author |
author2 |
Rosito, Tiago [UNIFESP] Pires, Jesus A. S. [UNIFESP] Liguori, Riberto [UNIFESP] Ortiz, Valdemar [UNIFESP] |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Macedo Jr., Antonio [UNIFESP] Rosito, Tiago [UNIFESP] Pires, Jesus A. S. [UNIFESP] Liguori, Riberto [UNIFESP] Ortiz, Valdemar [UNIFESP] |
dc.subject.eng.fl_str_mv |
bladder Children urinary diversion Mitrofanoff principle surgery |
topic |
bladder Children urinary diversion Mitrofanoff principle surgery |
description |
INTRODUCTION: The appendix is the gold-standard channel for the Mitrofanoff principle in pediatric urology, but the search for alternatives is justified considering it may not be available or preferably used for colonic stomas (Malone antegrade continence enema). The aim of this study is to report on technical feasibility of a new approach for creating catheterizable channels in a rabbit model and to present our preliminary clinical experience. MATERIAL AND METHODS: We configured a tube from two rectangular skin flaps 1x4 cm opposite each other in the middle line of the lower inferior abdomen. The channel was anastomosed to the bladder dome with embedding sutures to create a valvular mechanism. The experimental study consisted of 12 rabbits, divided in 4 groups according to the sacrifice schedule at 2, 4, 8 and 12 weeks. At 30th postoperative day, an urodynamic evaluation was performed to record continence of the stoma. A histological analysis of the specimens stained with hematoxylin-eosin, Masson trichrome and Picrosirius red was also done in group 2 (sacrifice at 4 weeks postoperatively). We used this method in 3 patients with congenital non-neurogenic bladder disease presenting with massive residual volumes without compliance deficits. RESULT: The technique proved feasible in all animals, 9 of 12 could be easily catheterized and underwent urodynamic study. No stoma leakage was observed in 7 animals at high bladder pressures (> 50 cm H20) and only 2 animals had some leakage at 40 cm H20. Urodynamics performed through the stoma showed urethral leakage at 20 cm H20, therefore demonstrating the efficacy of the valvular mechanism. Histological analysis confirmed good integration between the tube and the bladder. Mean follow-up of the clinical series (3 patients) was 7.2 months. Two patients remained continent up to 4 hours, whereas 1 patient had some leakage after 2 hours. CONCLUSION: We were able to confirm feasibility of a new extra-abdominal channel based on the Mitrofanoff principle and successfully reproduced the method in a clinical setting. Follow-up was short and long term results are required before any conclusive judgment can be made. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-04-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:39:10Z |
dc.date.available.fl_str_mv |
2015-06-14T13:39:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
International braz j urol. Sociedade Brasileira de Urologia, v. 35, n. 2, p. 205-216, 2009. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/4984 http://dx.doi.org/10.1590/S1677-55382009000200011 |
dc.identifier.issn.none.fl_str_mv |
1677-5538 |
dc.identifier.file.none.fl_str_mv |
S1677-55382009000200011.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1677-55382009000200011 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1677-55382009000200011 |
dc.identifier.wos.none.fl_str_mv |
WOS:000283286900027 |
identifier_str_mv |
International braz j urol. Sociedade Brasileira de Urologia, v. 35, n. 2, p. 205-216, 2009. 1677-5538 S1677-55382009000200011.pdf S1677-55382009000200011 10.1590/S1677-55382009000200011 WOS:000283286900027 |
url |
http://repositorio.unifesp.br/handle/11600/4984 http://dx.doi.org/10.1590/S1677-55382009000200011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
International braz j urol |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
205-216 |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Urologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/4984/1/S1677-55382009000200011.pdf ${dspace.ui.url}/bitstream/11600/4984/2/S1677-55382009000200011.pdf.txt |
bitstream.checksum.fl_str_mv |
b2dd8e9ccb685e7b325b6eb6f94563ef 03516570f554188f9860a53b624f3036 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764196801150976 |