Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise

• Autor(a) principal: Bernardes, Danielle
• Data de Publicação: 2013
• Outros Autores: Oliveira-Lima, Onesia Cristina, Silva, Thiago Vitarelli da, Faraco, Camila Cristina Fraga, Leite, Hercules Ribeiro, Juliano, Maria Aparecida [UNIFESP], Santos, Daniel Moreira dos, Bethea, John R., Brambilla, Roberta, Orian, Jacqueline M., Arantes, Rosa Maria Esteves, Carvalho-Tavares, Juliana
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://dx.doi.org/10.1016/j.jneuroim.2013.08.014; https://repositorio.unifesp.br/handle/11600/36978
• topic: Experimental autoimmune encephalomyelitis; Exercise; BDNF; Neuroprotection; Neuroinflammation; Intravital microscopy

The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. in the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised. (C) 2013 Elsevier B.V. All rights reserved.