Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion

Detalhes bibliográficos
Autor(a) principal: Okada, Mieko [UNIFESP]
Data de Publicação: 2017
Outros Autores: Reis Falcao, Luiz Fernando [UNIFESP], Ferez, David [UNIFESP], Martins, Jose Luiz [UNIFESP], Errante, Paolo Ruggero [UNIFESP], Menezes Rodrigues, Francisco Sandro [UNIFESP], Caricati-Neto, Afonso [UNIFESP], Marinho, Marcia, Fenelon, Guilherme [UNIFESP], Oliveira-Junior, Itamar Souza [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/s0102-865020170110000008
https://repositorio.unifesp.br/handle/11600/58222
Resumo: Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n= 8), anesthetized and divided in: Sham: submitted to operation only; group SS+ IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); group AT+ IR: intravenous atenolol infusion (2 mg/kg) following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); and group AT+ I+ AT+ R: intravenous atenolol infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and in the time 45 minutes other atenolol doses were administrated and the artery was open for 120 minutes (reperfusion), all animals were submitted to muscular relaxation for mechanical ventilation. In the end of experiment the animals were euthanized and the hearts tissue were morphology analyzed by histology and malondialdehyde by ELISA, and the plasma were analyzed for tumor necrosis factor-alpha by ELISA. Results: The group SS+ IR demonstrated the higher malondialdehyde levels when compared with the atenolol treated-groups (p= 0.001) in the heart tissue. The tumor necrosis factoralpha level in plasma decrease in the treated groups when compared with SS+ IR group (p= 0.001). Histology analyses demonstrate pyknosis, edema, cellular vacuolization, presence of inflammatory infiltrate and band contraction in the heart tissue of the rats. Conclusion: Atenolol significantly reduce the degree of cardiac damage after intestinal ischemia-reperfusion.
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spelling Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusionAdrenergic AntagonistsAtenololIschemiaReperfusionCytokinesOxidative StressRatsPurpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n= 8), anesthetized and divided in: Sham: submitted to operation only; group SS+ IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); group AT+ IR: intravenous atenolol infusion (2 mg/kg) following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); and group AT+ I+ AT+ R: intravenous atenolol infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and in the time 45 minutes other atenolol doses were administrated and the artery was open for 120 minutes (reperfusion), all animals were submitted to muscular relaxation for mechanical ventilation. In the end of experiment the animals were euthanized and the hearts tissue were morphology analyzed by histology and malondialdehyde by ELISA, and the plasma were analyzed for tumor necrosis factor-alpha by ELISA. Results: The group SS+ IR demonstrated the higher malondialdehyde levels when compared with the atenolol treated-groups (p= 0.001) in the heart tissue. The tumor necrosis factoralpha level in plasma decrease in the treated groups when compared with SS+ IR group (p= 0.001). Histology analyses demonstrate pyknosis, edema, cellular vacuolization, presence of inflammatory infiltrate and band contraction in the heart tissue of the rats. Conclusion: Atenolol significantly reduce the degree of cardiac damage after intestinal ischemia-reperfusion.Univ Fed Sao Paulo, UNIFESP, Postgrad Program Translat Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Surg, Div Anesthesia Pain & Intens Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Program Pharmacol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, BrazilUNESP, Vet Med Sch, Aracatuba, SP, BrazilUniv Fed Sao Paulo, Dept Surg, Div Cardiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Program Translat Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Postgrad Program Translat Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Surg, Div Anesthesia Pain & Intens Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Program Pharmacol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Surg, Div Cardiol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Program Translat Med, Sao Paulo, SP, BrazilWeb of ScienceFAPESPActa Cirurgica Brasileira2020-09-01T13:21:21Z2020-09-01T13:21:21Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion964-972application/pdfhttp://dx.doi.org/10.1590/s0102-865020170110000008Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 11, p. 964-972, 2017.10.1590/s0102-865020170110000008S0102-86502017001100964.pdf0102-8650S0102-86502017001100964https://repositorio.unifesp.br/handle/11600/58222WOS:000417846700008engActa Cirurgica BrasileiraSao Pauloinfo:eu-repo/semantics/openAccessOkada, Mieko [UNIFESP]Reis Falcao, Luiz Fernando [UNIFESP]Ferez, David [UNIFESP]Martins, Jose Luiz [UNIFESP]Errante, Paolo Ruggero [UNIFESP]Menezes Rodrigues, Francisco Sandro [UNIFESP]Caricati-Neto, Afonso [UNIFESP]Marinho, MarciaFenelon, Guilherme [UNIFESP]Oliveira-Junior, Itamar Souza [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T22:55:48Zoai:repositorio.unifesp.br/:11600/58222Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T22:55:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
title Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
spellingShingle Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
Okada, Mieko [UNIFESP]
Adrenergic Antagonists
Atenolol
Ischemia
Reperfusion
Cytokines
Oxidative Stress
Rats
title_short Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
title_full Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
title_fullStr Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
title_full_unstemmed Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
title_sort Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion
author Okada, Mieko [UNIFESP]
author_facet Okada, Mieko [UNIFESP]
Reis Falcao, Luiz Fernando [UNIFESP]
Ferez, David [UNIFESP]
Martins, Jose Luiz [UNIFESP]
Errante, Paolo Ruggero [UNIFESP]
Menezes Rodrigues, Francisco Sandro [UNIFESP]
Caricati-Neto, Afonso [UNIFESP]
Marinho, Marcia
Fenelon, Guilherme [UNIFESP]
Oliveira-Junior, Itamar Souza [UNIFESP]
author_role author
author2 Reis Falcao, Luiz Fernando [UNIFESP]
Ferez, David [UNIFESP]
Martins, Jose Luiz [UNIFESP]
Errante, Paolo Ruggero [UNIFESP]
Menezes Rodrigues, Francisco Sandro [UNIFESP]
Caricati-Neto, Afonso [UNIFESP]
Marinho, Marcia
Fenelon, Guilherme [UNIFESP]
Oliveira-Junior, Itamar Souza [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Okada, Mieko [UNIFESP]
Reis Falcao, Luiz Fernando [UNIFESP]
Ferez, David [UNIFESP]
Martins, Jose Luiz [UNIFESP]
Errante, Paolo Ruggero [UNIFESP]
Menezes Rodrigues, Francisco Sandro [UNIFESP]
Caricati-Neto, Afonso [UNIFESP]
Marinho, Marcia
Fenelon, Guilherme [UNIFESP]
Oliveira-Junior, Itamar Souza [UNIFESP]
dc.subject.por.fl_str_mv Adrenergic Antagonists
Atenolol
Ischemia
Reperfusion
Cytokines
Oxidative Stress
Rats
topic Adrenergic Antagonists
Atenolol
Ischemia
Reperfusion
Cytokines
Oxidative Stress
Rats
description Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n= 8), anesthetized and divided in: Sham: submitted to operation only; group SS+ IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); group AT+ IR: intravenous atenolol infusion (2 mg/kg) following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); and group AT+ I+ AT+ R: intravenous atenolol infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and in the time 45 minutes other atenolol doses were administrated and the artery was open for 120 minutes (reperfusion), all animals were submitted to muscular relaxation for mechanical ventilation. In the end of experiment the animals were euthanized and the hearts tissue were morphology analyzed by histology and malondialdehyde by ELISA, and the plasma were analyzed for tumor necrosis factor-alpha by ELISA. Results: The group SS+ IR demonstrated the higher malondialdehyde levels when compared with the atenolol treated-groups (p= 0.001) in the heart tissue. The tumor necrosis factoralpha level in plasma decrease in the treated groups when compared with SS+ IR group (p= 0.001). Histology analyses demonstrate pyknosis, edema, cellular vacuolization, presence of inflammatory infiltrate and band contraction in the heart tissue of the rats. Conclusion: Atenolol significantly reduce the degree of cardiac damage after intestinal ischemia-reperfusion.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-09-01T13:21:21Z
2020-09-01T13:21:21Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/s0102-865020170110000008
Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 11, p. 964-972, 2017.
10.1590/s0102-865020170110000008
S0102-86502017001100964.pdf
0102-8650
S0102-86502017001100964
https://repositorio.unifesp.br/handle/11600/58222
WOS:000417846700008
url http://dx.doi.org/10.1590/s0102-865020170110000008
https://repositorio.unifesp.br/handle/11600/58222
identifier_str_mv Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 11, p. 964-972, 2017.
10.1590/s0102-865020170110000008
S0102-86502017001100964.pdf
0102-8650
S0102-86502017001100964
WOS:000417846700008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 964-972
application/pdf
dc.coverage.none.fl_str_mv Sao Paulo
dc.publisher.none.fl_str_mv Acta Cirurgica Brasileira
publisher.none.fl_str_mv Acta Cirurgica Brasileira
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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