Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/0013000017kv9 |
Texto Completo: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907882/ http://repositorio.unifesp.br/handle/11600/43637 |
Resumo: | BACKGROUND: Hypertensive diabetic patients, when compared with essential hypertensive patients, have a higher left ventricular mass index (LVMI) and an impaired cardiac diastolic function (CDF). Autonomic neuropathy (AN) could contribute to this finding.OBJECTIVE: To evaluate the relationship between AN tests, and LVMI and CDF in normotensive patients with type 2 diabetes mellitus (DM2) and without AN symptoms or left ventricular hypertrophy.METHODS: In 21 normotensive patients with DM2 (group 1) and 16 control subjects (group 2), LVMI and CDF were evaluated using atrial deceleration time, isovolumic relaxation time, E wave, A wave and E/A wave ratio. AN tests performed included a deep breathing test, Valsalva manoeuvre and lying-to-standing test.RESULTS: Groups did not differ in clinical and echocardiographic characteristics. None of the patients in either group presented with left ventricular hypertrophy. In group 1, there were correlations between the deep breathing test and LVMI (r=-0.6; P<0.01) and between the deep breathing test and E/A wave ratio (r=0.4; P<0.05). No correlations were found in the control group.CONCLUSION: In DM2 patients, AN tests correlated with LVMI and CDF before left ventricular hypertrophy, hypertension, impaired CDF and diabetic AN symptoms were present. The present study suggests that AN tests could be regularly performed in DM2 patients. Any abnormalities in tests should be followed by a cardiac evaluation. |
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Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophyDiabetes mellitus type 2Diabetic autonomic neuropathyDiabetic cardiomyopathyBACKGROUND: Hypertensive diabetic patients, when compared with essential hypertensive patients, have a higher left ventricular mass index (LVMI) and an impaired cardiac diastolic function (CDF). Autonomic neuropathy (AN) could contribute to this finding.OBJECTIVE: To evaluate the relationship between AN tests, and LVMI and CDF in normotensive patients with type 2 diabetes mellitus (DM2) and without AN symptoms or left ventricular hypertrophy.METHODS: In 21 normotensive patients with DM2 (group 1) and 16 control subjects (group 2), LVMI and CDF were evaluated using atrial deceleration time, isovolumic relaxation time, E wave, A wave and E/A wave ratio. AN tests performed included a deep breathing test, Valsalva manoeuvre and lying-to-standing test.RESULTS: Groups did not differ in clinical and echocardiographic characteristics. None of the patients in either group presented with left ventricular hypertrophy. In group 1, there were correlations between the deep breathing test and LVMI (r=-0.6; P<0.01) and between the deep breathing test and E/A wave ratio (r=0.4; P<0.05). No correlations were found in the control group.CONCLUSION: In DM2 patients, AN tests correlated with LVMI and CDF before left ventricular hypertrophy, hypertension, impaired CDF and diabetic AN symptoms were present. The present study suggests that AN tests could be regularly performed in DM2 patients. Any abnormalities in tests should be followed by a cardiac evaluation.Fed Univ Para, Div Endocrinol, BR-66073000 Belem, Para, BrazilHosp Univ Joao de Barros Barreto, Belem, Para, BrazilEscola Paulista Med, BR-04023 Sao Paulo, BrazilEscola Paulista Med, BR-04023 Sao Paulo, BrazilWeb of SciencePulsus Group IncFed Univ ParaHosp Univ Joao de Barros BarretoUniversidade Federal de São Paulo (UNIFESP)Felicio, Joao Soares [UNIFESP]Santos, Flavia M.Souza, Ana Carolina C. B. deFelicio, Karem M.Ribeiro, Arthur Beltrame [UNIFESP]Zanella, Maria Teresa [UNIFESP]2018-06-15T17:22:31Z2018-06-15T17:22:31Z2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionE5-E9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907882/Experimental & Clinical Cardiology. Oakville: Pulsus Group Inc, v. 15, n. 1, p. E5-E9, 2010.1205-6626http://repositorio.unifesp.br/handle/11600/43637WOS:000208230200002ark:/48912/0013000017kv9engExperimental & Clinical Cardiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:58:04Zoai:repositorio.unifesp.br/:11600/43637Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T21:01:48.487249Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy |
title |
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy |
spellingShingle |
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy Felicio, Joao Soares [UNIFESP] Diabetes mellitus type 2 Diabetic autonomic neuropathy Diabetic cardiomyopathy |
title_short |
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy |
title_full |
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy |
title_fullStr |
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy |
title_full_unstemmed |
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy |
title_sort |
Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy |
author |
Felicio, Joao Soares [UNIFESP] |
author_facet |
Felicio, Joao Soares [UNIFESP] Santos, Flavia M. Souza, Ana Carolina C. B. de Felicio, Karem M. Ribeiro, Arthur Beltrame [UNIFESP] Zanella, Maria Teresa [UNIFESP] |
author_role |
author |
author2 |
Santos, Flavia M. Souza, Ana Carolina C. B. de Felicio, Karem M. Ribeiro, Arthur Beltrame [UNIFESP] Zanella, Maria Teresa [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Fed Univ Para Hosp Univ Joao de Barros Barreto Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Felicio, Joao Soares [UNIFESP] Santos, Flavia M. Souza, Ana Carolina C. B. de Felicio, Karem M. Ribeiro, Arthur Beltrame [UNIFESP] Zanella, Maria Teresa [UNIFESP] |
dc.subject.por.fl_str_mv |
Diabetes mellitus type 2 Diabetic autonomic neuropathy Diabetic cardiomyopathy |
topic |
Diabetes mellitus type 2 Diabetic autonomic neuropathy Diabetic cardiomyopathy |
description |
BACKGROUND: Hypertensive diabetic patients, when compared with essential hypertensive patients, have a higher left ventricular mass index (LVMI) and an impaired cardiac diastolic function (CDF). Autonomic neuropathy (AN) could contribute to this finding.OBJECTIVE: To evaluate the relationship between AN tests, and LVMI and CDF in normotensive patients with type 2 diabetes mellitus (DM2) and without AN symptoms or left ventricular hypertrophy.METHODS: In 21 normotensive patients with DM2 (group 1) and 16 control subjects (group 2), LVMI and CDF were evaluated using atrial deceleration time, isovolumic relaxation time, E wave, A wave and E/A wave ratio. AN tests performed included a deep breathing test, Valsalva manoeuvre and lying-to-standing test.RESULTS: Groups did not differ in clinical and echocardiographic characteristics. None of the patients in either group presented with left ventricular hypertrophy. In group 1, there were correlations between the deep breathing test and LVMI (r=-0.6; P<0.01) and between the deep breathing test and E/A wave ratio (r=0.4; P<0.05). No correlations were found in the control group.CONCLUSION: In DM2 patients, AN tests correlated with LVMI and CDF before left ventricular hypertrophy, hypertension, impaired CDF and diabetic AN symptoms were present. The present study suggests that AN tests could be regularly performed in DM2 patients. Any abnormalities in tests should be followed by a cardiac evaluation. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03-01 2018-06-15T17:22:31Z 2018-06-15T17:22:31Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907882/ Experimental & Clinical Cardiology. Oakville: Pulsus Group Inc, v. 15, n. 1, p. E5-E9, 2010. 1205-6626 http://repositorio.unifesp.br/handle/11600/43637 WOS:000208230200002 |
dc.identifier.dark.fl_str_mv |
ark:/48912/0013000017kv9 |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907882/ http://repositorio.unifesp.br/handle/11600/43637 |
identifier_str_mv |
Experimental & Clinical Cardiology. Oakville: Pulsus Group Inc, v. 15, n. 1, p. E5-E9, 2010. 1205-6626 WOS:000208230200002 ark:/48912/0013000017kv9 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Experimental & Clinical Cardiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
E5-E9 |
dc.publisher.none.fl_str_mv |
Pulsus Group Inc |
publisher.none.fl_str_mv |
Pulsus Group Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1818602588860317696 |