Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy

Detalhes bibliográficos
Autor(a) principal: Felicio, Joao Soares [UNIFESP]
Data de Publicação: 2010
Outros Autores: Santos, Flavia M., Souza, Ana Carolina C. B. de, Felicio, Karem M., Ribeiro, Arthur Beltrame [UNIFESP], Zanella, Maria Teresa [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000017kv9
Texto Completo: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907882/
http://repositorio.unifesp.br/handle/11600/43637
Resumo: BACKGROUND: Hypertensive diabetic patients, when compared with essential hypertensive patients, have a higher left ventricular mass index (LVMI) and an impaired cardiac diastolic function (CDF). Autonomic neuropathy (AN) could contribute to this finding.OBJECTIVE: To evaluate the relationship between AN tests, and LVMI and CDF in normotensive patients with type 2 diabetes mellitus (DM2) and without AN symptoms or left ventricular hypertrophy.METHODS: In 21 normotensive patients with DM2 (group 1) and 16 control subjects (group 2), LVMI and CDF were evaluated using atrial deceleration time, isovolumic relaxation time, E wave, A wave and E/A wave ratio. AN tests performed included a deep breathing test, Valsalva manoeuvre and lying-to-standing test.RESULTS: Groups did not differ in clinical and echocardiographic characteristics. None of the patients in either group presented with left ventricular hypertrophy. In group 1, there were correlations between the deep breathing test and LVMI (r=-0.6; P<0.01) and between the deep breathing test and E/A wave ratio (r=0.4; P<0.05). No correlations were found in the control group.CONCLUSION: In DM2 patients, AN tests correlated with LVMI and CDF before left ventricular hypertrophy, hypertension, impaired CDF and diabetic AN symptoms were present. The present study suggests that AN tests could be regularly performed in DM2 patients. Any abnormalities in tests should be followed by a cardiac evaluation.
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spelling Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophyDiabetes mellitus type 2Diabetic autonomic neuropathyDiabetic cardiomyopathyBACKGROUND: Hypertensive diabetic patients, when compared with essential hypertensive patients, have a higher left ventricular mass index (LVMI) and an impaired cardiac diastolic function (CDF). Autonomic neuropathy (AN) could contribute to this finding.OBJECTIVE: To evaluate the relationship between AN tests, and LVMI and CDF in normotensive patients with type 2 diabetes mellitus (DM2) and without AN symptoms or left ventricular hypertrophy.METHODS: In 21 normotensive patients with DM2 (group 1) and 16 control subjects (group 2), LVMI and CDF were evaluated using atrial deceleration time, isovolumic relaxation time, E wave, A wave and E/A wave ratio. AN tests performed included a deep breathing test, Valsalva manoeuvre and lying-to-standing test.RESULTS: Groups did not differ in clinical and echocardiographic characteristics. None of the patients in either group presented with left ventricular hypertrophy. In group 1, there were correlations between the deep breathing test and LVMI (r=-0.6; P<0.01) and between the deep breathing test and E/A wave ratio (r=0.4; P<0.05). No correlations were found in the control group.CONCLUSION: In DM2 patients, AN tests correlated with LVMI and CDF before left ventricular hypertrophy, hypertension, impaired CDF and diabetic AN symptoms were present. The present study suggests that AN tests could be regularly performed in DM2 patients. Any abnormalities in tests should be followed by a cardiac evaluation.Fed Univ Para, Div Endocrinol, BR-66073000 Belem, Para, BrazilHosp Univ Joao de Barros Barreto, Belem, Para, BrazilEscola Paulista Med, BR-04023 Sao Paulo, BrazilEscola Paulista Med, BR-04023 Sao Paulo, BrazilWeb of SciencePulsus Group IncFed Univ ParaHosp Univ Joao de Barros BarretoUniversidade Federal de São Paulo (UNIFESP)Felicio, Joao Soares [UNIFESP]Santos, Flavia M.Souza, Ana Carolina C. B. deFelicio, Karem M.Ribeiro, Arthur Beltrame [UNIFESP]Zanella, Maria Teresa [UNIFESP]2018-06-15T17:22:31Z2018-06-15T17:22:31Z2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionE5-E9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907882/Experimental & Clinical Cardiology. Oakville: Pulsus Group Inc, v. 15, n. 1, p. E5-E9, 2010.1205-6626http://repositorio.unifesp.br/handle/11600/43637WOS:000208230200002ark:/48912/0013000017kv9engExperimental & Clinical Cardiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:58:04Zoai:repositorio.unifesp.br/:11600/43637Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T21:01:48.487249Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
title Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
spellingShingle Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
Felicio, Joao Soares [UNIFESP]
Diabetes mellitus type 2
Diabetic autonomic neuropathy
Diabetic cardiomyopathy
title_short Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
title_full Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
title_fullStr Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
title_full_unstemmed Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
title_sort Autonomic neuropathy tests correlate with left ventricular mass and cardiac diastolic function in normotensive patients with type 2 diabetes mellitus and without left ventricular hypertrophy
author Felicio, Joao Soares [UNIFESP]
author_facet Felicio, Joao Soares [UNIFESP]
Santos, Flavia M.
Souza, Ana Carolina C. B. de
Felicio, Karem M.
Ribeiro, Arthur Beltrame [UNIFESP]
Zanella, Maria Teresa [UNIFESP]
author_role author
author2 Santos, Flavia M.
Souza, Ana Carolina C. B. de
Felicio, Karem M.
Ribeiro, Arthur Beltrame [UNIFESP]
Zanella, Maria Teresa [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Fed Univ Para
Hosp Univ Joao de Barros Barreto
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Felicio, Joao Soares [UNIFESP]
Santos, Flavia M.
Souza, Ana Carolina C. B. de
Felicio, Karem M.
Ribeiro, Arthur Beltrame [UNIFESP]
Zanella, Maria Teresa [UNIFESP]
dc.subject.por.fl_str_mv Diabetes mellitus type 2
Diabetic autonomic neuropathy
Diabetic cardiomyopathy
topic Diabetes mellitus type 2
Diabetic autonomic neuropathy
Diabetic cardiomyopathy
description BACKGROUND: Hypertensive diabetic patients, when compared with essential hypertensive patients, have a higher left ventricular mass index (LVMI) and an impaired cardiac diastolic function (CDF). Autonomic neuropathy (AN) could contribute to this finding.OBJECTIVE: To evaluate the relationship between AN tests, and LVMI and CDF in normotensive patients with type 2 diabetes mellitus (DM2) and without AN symptoms or left ventricular hypertrophy.METHODS: In 21 normotensive patients with DM2 (group 1) and 16 control subjects (group 2), LVMI and CDF were evaluated using atrial deceleration time, isovolumic relaxation time, E wave, A wave and E/A wave ratio. AN tests performed included a deep breathing test, Valsalva manoeuvre and lying-to-standing test.RESULTS: Groups did not differ in clinical and echocardiographic characteristics. None of the patients in either group presented with left ventricular hypertrophy. In group 1, there were correlations between the deep breathing test and LVMI (r=-0.6; P<0.01) and between the deep breathing test and E/A wave ratio (r=0.4; P<0.05). No correlations were found in the control group.CONCLUSION: In DM2 patients, AN tests correlated with LVMI and CDF before left ventricular hypertrophy, hypertension, impaired CDF and diabetic AN symptoms were present. The present study suggests that AN tests could be regularly performed in DM2 patients. Any abnormalities in tests should be followed by a cardiac evaluation.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
2018-06-15T17:22:31Z
2018-06-15T17:22:31Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907882/
Experimental & Clinical Cardiology. Oakville: Pulsus Group Inc, v. 15, n. 1, p. E5-E9, 2010.
1205-6626
http://repositorio.unifesp.br/handle/11600/43637
WOS:000208230200002
dc.identifier.dark.fl_str_mv ark:/48912/0013000017kv9
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907882/
http://repositorio.unifesp.br/handle/11600/43637
identifier_str_mv Experimental & Clinical Cardiology. Oakville: Pulsus Group Inc, v. 15, n. 1, p. E5-E9, 2010.
1205-6626
WOS:000208230200002
ark:/48912/0013000017kv9
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Experimental & Clinical Cardiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv E5-E9
dc.publisher.none.fl_str_mv Pulsus Group Inc
publisher.none.fl_str_mv Pulsus Group Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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