Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1186/1916-0216-42-45 http://repositorio.unifesp.br/handle/11600/36544 |
Resumo: | The superantigenic properties of Staphylococcus aureus have been implicated in increasing the inflammatory process in airway diseases. Local formation of IgE antibodies against staphylococcal enterotoxins by secondary lymphoid tissue in nasal polyps has been demonstrated. Staphylococcus aureus is known to colonize the nasal mucosa, and has been found invading the nasal submucosa and intracellularly.Objective: To evaluate the limits of Staphylococcus aureus invasion in the upper airway.Material and methods: Inferior turbinate samples from 3 patients without sinus disease, 6 ethmoid samples from patients with chronic rhinosinusitis with nasal polyposis, and 6 ethmoid samples from patients with chronic rhinosinusitis without nasal polyposis were studied. A fluorescein-labeled PNA probe against Staphylococcus aureus was used to test for the presence of the bacterium in bone (after decalcification) and mucosa.Results: We found Staphylococcus aureus invading the nasal submucosa in patients with nasal polyposis, but no cases of Staphylococcus aureus positivity in bone. in conclusion, we cannot support the hypothesis of nasal bone as a reservoir for Staphylococcus aureus, releasing massive amounts of staphylococcal enterotoxins and eliciting an inflammatory reaction, as occurs with the nasal mucosa. |
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Repositório Institucional da UNIFESP |
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Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitisRhinosinusitisBoneStaphylococcus aureusAirwayThe superantigenic properties of Staphylococcus aureus have been implicated in increasing the inflammatory process in airway diseases. Local formation of IgE antibodies against staphylococcal enterotoxins by secondary lymphoid tissue in nasal polyps has been demonstrated. Staphylococcus aureus is known to colonize the nasal mucosa, and has been found invading the nasal submucosa and intracellularly.Objective: To evaluate the limits of Staphylococcus aureus invasion in the upper airway.Material and methods: Inferior turbinate samples from 3 patients without sinus disease, 6 ethmoid samples from patients with chronic rhinosinusitis with nasal polyposis, and 6 ethmoid samples from patients with chronic rhinosinusitis without nasal polyposis were studied. A fluorescein-labeled PNA probe against Staphylococcus aureus was used to test for the presence of the bacterium in bone (after decalcification) and mucosa.Results: We found Staphylococcus aureus invading the nasal submucosa in patients with nasal polyposis, but no cases of Staphylococcus aureus positivity in bone. in conclusion, we cannot support the hypothesis of nasal bone as a reservoir for Staphylococcus aureus, releasing massive amounts of staphylococcal enterotoxins and eliciting an inflammatory reaction, as occurs with the nasal mucosa.Univ São Paulo, Dept Otorhinolaryngol, São Paulo, BrazilSão Paulo State Mil Police, Mil Police Hosp, São Paulo, BrazilFed Univ São Paulo Unifesp, Dept Otorhinolaryngol, São Paulo, BrazilFed Univ São Paulo Unifesp, Dept Immunol, São Paulo, BrazilFed Univ São Paulo Unifesp, Dept Otorhinolaryngol, São Paulo, BrazilFed Univ São Paulo Unifesp, Dept Immunol, São Paulo, BrazilWeb of ScienceBiomed Central LtdUniversidade de São Paulo (USP)São Paulo State Mil PoliceUniversidade Federal de São Paulo (UNIFESP)Pezato, Rogerio [UNIFESP]Bottura, LucianoSantos, Rodrigo de Paula [UNIFESP]Voegels, Richard LouisBachi, Andre Luis Lacerda [UNIFESP]Gregório, Luis Carlos [UNIFESP]2016-01-24T14:32:00Z2016-01-24T14:32:00Z2013-07-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5application/pdfhttp://dx.doi.org/10.1186/1916-0216-42-45Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.10.1186/1916-0216-42-45WOS000322196600001.pdf1916-0216http://repositorio.unifesp.br/handle/11600/36544WOS:000322196600001engJournal of Otolaryngology-head & Neck Surgeryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T13:01:39Zoai:repositorio.unifesp.br/:11600/36544Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T13:01:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis |
title |
Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis |
spellingShingle |
Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis Pezato, Rogerio [UNIFESP] Rhinosinusitis Bone Staphylococcus aureus Airway |
title_short |
Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis |
title_full |
Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis |
title_fullStr |
Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis |
title_full_unstemmed |
Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis |
title_sort |
Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis |
author |
Pezato, Rogerio [UNIFESP] |
author_facet |
Pezato, Rogerio [UNIFESP] Bottura, Luciano Santos, Rodrigo de Paula [UNIFESP] Voegels, Richard Louis Bachi, Andre Luis Lacerda [UNIFESP] Gregório, Luis Carlos [UNIFESP] |
author_role |
author |
author2 |
Bottura, Luciano Santos, Rodrigo de Paula [UNIFESP] Voegels, Richard Louis Bachi, Andre Luis Lacerda [UNIFESP] Gregório, Luis Carlos [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) São Paulo State Mil Police Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Pezato, Rogerio [UNIFESP] Bottura, Luciano Santos, Rodrigo de Paula [UNIFESP] Voegels, Richard Louis Bachi, Andre Luis Lacerda [UNIFESP] Gregório, Luis Carlos [UNIFESP] |
dc.subject.por.fl_str_mv |
Rhinosinusitis Bone Staphylococcus aureus Airway |
topic |
Rhinosinusitis Bone Staphylococcus aureus Airway |
description |
The superantigenic properties of Staphylococcus aureus have been implicated in increasing the inflammatory process in airway diseases. Local formation of IgE antibodies against staphylococcal enterotoxins by secondary lymphoid tissue in nasal polyps has been demonstrated. Staphylococcus aureus is known to colonize the nasal mucosa, and has been found invading the nasal submucosa and intracellularly.Objective: To evaluate the limits of Staphylococcus aureus invasion in the upper airway.Material and methods: Inferior turbinate samples from 3 patients without sinus disease, 6 ethmoid samples from patients with chronic rhinosinusitis with nasal polyposis, and 6 ethmoid samples from patients with chronic rhinosinusitis without nasal polyposis were studied. A fluorescein-labeled PNA probe against Staphylococcus aureus was used to test for the presence of the bacterium in bone (after decalcification) and mucosa.Results: We found Staphylococcus aureus invading the nasal submucosa in patients with nasal polyposis, but no cases of Staphylococcus aureus positivity in bone. in conclusion, we cannot support the hypothesis of nasal bone as a reservoir for Staphylococcus aureus, releasing massive amounts of staphylococcal enterotoxins and eliciting an inflammatory reaction, as occurs with the nasal mucosa. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-07-19 2016-01-24T14:32:00Z 2016-01-24T14:32:00Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1916-0216-42-45 Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013. 10.1186/1916-0216-42-45 WOS000322196600001.pdf 1916-0216 http://repositorio.unifesp.br/handle/11600/36544 WOS:000322196600001 |
url |
http://dx.doi.org/10.1186/1916-0216-42-45 http://repositorio.unifesp.br/handle/11600/36544 |
identifier_str_mv |
Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013. 10.1186/1916-0216-42-45 WOS000322196600001.pdf 1916-0216 WOS:000322196600001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Otolaryngology-head & Neck Surgery |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268373776728064 |