Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis

Detalhes bibliográficos
Autor(a) principal: Pezato, Rogerio [UNIFESP]
Data de Publicação: 2013
Outros Autores: Bottura, Luciano, Santos, Rodrigo de Paula [UNIFESP], Voegels, Richard Louis, Bachi, Andre Luis Lacerda [UNIFESP], Gregório, Luis Carlos [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1186/1916-0216-42-45
http://repositorio.unifesp.br/handle/11600/36544
Resumo: The superantigenic properties of Staphylococcus aureus have been implicated in increasing the inflammatory process in airway diseases. Local formation of IgE antibodies against staphylococcal enterotoxins by secondary lymphoid tissue in nasal polyps has been demonstrated. Staphylococcus aureus is known to colonize the nasal mucosa, and has been found invading the nasal submucosa and intracellularly.Objective: To evaluate the limits of Staphylococcus aureus invasion in the upper airway.Material and methods: Inferior turbinate samples from 3 patients without sinus disease, 6 ethmoid samples from patients with chronic rhinosinusitis with nasal polyposis, and 6 ethmoid samples from patients with chronic rhinosinusitis without nasal polyposis were studied. A fluorescein-labeled PNA probe against Staphylococcus aureus was used to test for the presence of the bacterium in bone (after decalcification) and mucosa.Results: We found Staphylococcus aureus invading the nasal submucosa in patients with nasal polyposis, but no cases of Staphylococcus aureus positivity in bone. in conclusion, we cannot support the hypothesis of nasal bone as a reservoir for Staphylococcus aureus, releasing massive amounts of staphylococcal enterotoxins and eliciting an inflammatory reaction, as occurs with the nasal mucosa.
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spelling Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitisRhinosinusitisBoneStaphylococcus aureusAirwayThe superantigenic properties of Staphylococcus aureus have been implicated in increasing the inflammatory process in airway diseases. Local formation of IgE antibodies against staphylococcal enterotoxins by secondary lymphoid tissue in nasal polyps has been demonstrated. Staphylococcus aureus is known to colonize the nasal mucosa, and has been found invading the nasal submucosa and intracellularly.Objective: To evaluate the limits of Staphylococcus aureus invasion in the upper airway.Material and methods: Inferior turbinate samples from 3 patients without sinus disease, 6 ethmoid samples from patients with chronic rhinosinusitis with nasal polyposis, and 6 ethmoid samples from patients with chronic rhinosinusitis without nasal polyposis were studied. A fluorescein-labeled PNA probe against Staphylococcus aureus was used to test for the presence of the bacterium in bone (after decalcification) and mucosa.Results: We found Staphylococcus aureus invading the nasal submucosa in patients with nasal polyposis, but no cases of Staphylococcus aureus positivity in bone. in conclusion, we cannot support the hypothesis of nasal bone as a reservoir for Staphylococcus aureus, releasing massive amounts of staphylococcal enterotoxins and eliciting an inflammatory reaction, as occurs with the nasal mucosa.Univ São Paulo, Dept Otorhinolaryngol, São Paulo, BrazilSão Paulo State Mil Police, Mil Police Hosp, São Paulo, BrazilFed Univ São Paulo Unifesp, Dept Otorhinolaryngol, São Paulo, BrazilFed Univ São Paulo Unifesp, Dept Immunol, São Paulo, BrazilFed Univ São Paulo Unifesp, Dept Otorhinolaryngol, São Paulo, BrazilFed Univ São Paulo Unifesp, Dept Immunol, São Paulo, BrazilWeb of ScienceBiomed Central LtdUniversidade de São Paulo (USP)São Paulo State Mil PoliceUniversidade Federal de São Paulo (UNIFESP)Pezato, Rogerio [UNIFESP]Bottura, LucianoSantos, Rodrigo de Paula [UNIFESP]Voegels, Richard LouisBachi, Andre Luis Lacerda [UNIFESP]Gregório, Luis Carlos [UNIFESP]2016-01-24T14:32:00Z2016-01-24T14:32:00Z2013-07-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5application/pdfhttp://dx.doi.org/10.1186/1916-0216-42-45Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.10.1186/1916-0216-42-45WOS000322196600001.pdf1916-0216http://repositorio.unifesp.br/handle/11600/36544WOS:000322196600001engJournal of Otolaryngology-head & Neck Surgeryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T13:01:39Zoai:repositorio.unifesp.br/:11600/36544Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T13:01:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
title Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
spellingShingle Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
Pezato, Rogerio [UNIFESP]
Rhinosinusitis
Bone
Staphylococcus aureus
Airway
title_short Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
title_full Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
title_fullStr Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
title_full_unstemmed Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
title_sort Bone: the final frontier for Staphylococcus aureus penetration in chronic rhinosinusitis
author Pezato, Rogerio [UNIFESP]
author_facet Pezato, Rogerio [UNIFESP]
Bottura, Luciano
Santos, Rodrigo de Paula [UNIFESP]
Voegels, Richard Louis
Bachi, Andre Luis Lacerda [UNIFESP]
Gregório, Luis Carlos [UNIFESP]
author_role author
author2 Bottura, Luciano
Santos, Rodrigo de Paula [UNIFESP]
Voegels, Richard Louis
Bachi, Andre Luis Lacerda [UNIFESP]
Gregório, Luis Carlos [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
São Paulo State Mil Police
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Pezato, Rogerio [UNIFESP]
Bottura, Luciano
Santos, Rodrigo de Paula [UNIFESP]
Voegels, Richard Louis
Bachi, Andre Luis Lacerda [UNIFESP]
Gregório, Luis Carlos [UNIFESP]
dc.subject.por.fl_str_mv Rhinosinusitis
Bone
Staphylococcus aureus
Airway
topic Rhinosinusitis
Bone
Staphylococcus aureus
Airway
description The superantigenic properties of Staphylococcus aureus have been implicated in increasing the inflammatory process in airway diseases. Local formation of IgE antibodies against staphylococcal enterotoxins by secondary lymphoid tissue in nasal polyps has been demonstrated. Staphylococcus aureus is known to colonize the nasal mucosa, and has been found invading the nasal submucosa and intracellularly.Objective: To evaluate the limits of Staphylococcus aureus invasion in the upper airway.Material and methods: Inferior turbinate samples from 3 patients without sinus disease, 6 ethmoid samples from patients with chronic rhinosinusitis with nasal polyposis, and 6 ethmoid samples from patients with chronic rhinosinusitis without nasal polyposis were studied. A fluorescein-labeled PNA probe against Staphylococcus aureus was used to test for the presence of the bacterium in bone (after decalcification) and mucosa.Results: We found Staphylococcus aureus invading the nasal submucosa in patients with nasal polyposis, but no cases of Staphylococcus aureus positivity in bone. in conclusion, we cannot support the hypothesis of nasal bone as a reservoir for Staphylococcus aureus, releasing massive amounts of staphylococcal enterotoxins and eliciting an inflammatory reaction, as occurs with the nasal mucosa.
publishDate 2013
dc.date.none.fl_str_mv 2013-07-19
2016-01-24T14:32:00Z
2016-01-24T14:32:00Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/1916-0216-42-45
Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
10.1186/1916-0216-42-45
WOS000322196600001.pdf
1916-0216
http://repositorio.unifesp.br/handle/11600/36544
WOS:000322196600001
url http://dx.doi.org/10.1186/1916-0216-42-45
http://repositorio.unifesp.br/handle/11600/36544
identifier_str_mv Journal of Otolaryngology-head & Neck Surgery. London: Biomed Central Ltd, v. 42, 5 p., 2013.
10.1186/1916-0216-42-45
WOS000322196600001.pdf
1916-0216
WOS:000322196600001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Otolaryngology-head & Neck Surgery
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5
application/pdf
dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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