SERUM LEVELS OF ANDROSTANEDIOL GLUCURONIDE, TOTAL TESTOSTERONE, AND FREE TESTOSTERONE IN HIRSUTE WOMEN

• Autor(a) principal: Khoury, Marcos Yorghi [UNIFESP]
• Data de Publicação: 1994
• Outros Autores: Baracat, Edmund Chada [UNIFESP], Pardini, Dolores Perovano [UNIFESP], Vieira, Jose Gilberto Henriques [UNIFESP], De Lima, Geraldo Rodrigues [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://www.fertstert.org/article/S0015-0282(16)56819-8/pdf; http://repositorio.unifesp.br/handle/11600/43682
• topic: ANDROSTANEDIOL GLUCURONIDE; TESTOSTERONE; HIRSUTISM

Objective: To determine the serum levels of androstanediol glucuronide (3 alpha-diol G), total T, and free T in hirsute and nonhirsute women.Design: Controlled clinical study.Patients: Hirsute women with oligomenorrhea, hirsute women with regular ovulatory cycles, and nonhirsute women with regular cycles were selected.Main Outcome Measure: Serum levels of 3 alpha-diol G, total T, and free T were measured in 8 hirsute with oligomenorrhea and 11 hirsute women with regular ovulatory cycles and compared with 20 nonhirsute women with regular cycles (control group). Serum 3 alpha-diol G was also measured during the follicular, periovulatory, and luteal phases in hirsute women with regular cycles.Results: Serum levels of 3 alpha-diol G did not change during the menstrual cycle, in addition we observed that there was no difference between the levels of 3 alpha-diol G, total T, and free T in hirsute women with regular cycles when compared with normal women. These three serum androgens were elevated only in the hirsute women with oligomenorrhea. Besides, there was better correlation between total T and free T (r = 0.81) than total T and 3 alpha-diol G (r = 0.49) or free T and 3 alpha-diol G (r = 0.66).Conclusion: The findings suggest that serum 3 alpha-diol G does not provide additional benefit as a marker of hirsutism than serum total or free T.