Análise histopatológica e imuno-histoquímica (antígeno nuclear de proliferação celular) de pacientes com carcinoma cervical invasor antes e após radioterapia e cirurgia

• Autor(a) principal: Rosal, Marta Alves [UNIFESP]
• Data de Publicação: 2002
• Outros Autores: Goncalves, Wagner Jose [UNIFESP], Alves, Maria Teresa de Seixas [UNIFESP], Baracat, Edmund Chada [UNIFESP], Lima, Geraldo Rodrigues de [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0104-42302002000100029; http://repositorio.unifesp.br/handle/11600/1375
• topic: Carcinoma cervical; Radiotherapy; Surgery; Residual neoplasia; PCNA; Carcinoma do colo uterino; Radioterapia; Cirurgia; Tumor residual; PCNA

OBJECTIVE: To search for residual disease and to analyse the Proliferating Cellular Nuclear Antigen (PCNA) status, in patients with cervical squamous cell carcinoma, treated with both radiotherapy and surgery. METHODS: Histological slides from 16 patients with uterine cervix cancer, treated between April 1986 and August 1998, with preoperative radiotherapy and surgery, were reviewed. PCNA imunohistochemical reactivity of these samples was evalued, using the IMAGELAB 2.3 computer image analysis system. RESULTS: Residual carcinoma were found in eight cases (50%) and no malignant features was found in eight cases (50%). The mean value of PCNA before radiotherapy in patients with residual cancer was 61.56% and in cases without residual cancer was 60%. Its expression before radiotherapy was between 27.91% and 89.93% (60% average), while after radiotherapy it varied between 55.80% and 86.73% (74% average). CONCLUSIONS: The association between preoperative radiotherapy followed by surgery is adequated to treat patients with cervical cancer, when radical treatment is not possible. Meanwhile, exclusive radiotherapy shows a significant failure rate, detected after surgery and PCNA analysis.