Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice

Detalhes bibliográficos
Autor(a) principal: Longo, Beatriz [UNIFESP]
Data de Publicação: 2010
Outros Autores: Romariz, Simone [UNIFESP], Blanco, Miriam Marcela [UNIFESP], Vasconcelos, Juliana Fraga, Bahia, Luciana, Pereira Soares, Milena Botelho, Mello, Luiz E. [UNIFESP], Ribeiro-dos-Santos, Ricardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1111/j.1528-1167.2010.02570.x
http://repositorio.unifesp.br/handle/11600/32744
Resumo: P>The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP+ bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. the pattern of distribution, proliferation, and differentiation of GFP+ cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.
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spelling Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in miceHippocampusChimeric miceMicrogliaStatus epilepticusGFPP>The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP+ bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. the pattern of distribution, proliferation, and differentiation of GFP+ cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.Universidade Federal de São Paulo, Dept Fisiol, Lab Neurofisiol, São Paulo, BrazilHosp Sao Rafael, Ctr Biotecnol & Terapia Celular, BR-41253190 Salvador, BA, BrazilUniversidade Federal de São Paulo, Dept Fisiol, Lab Neurofisiol, São Paulo, BrazilWeb of ScienceFAPESBFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FIOCRUZWiley-BlackwellUniversidade Federal de São Paulo (UNIFESP)Hosp Sao RafaelLongo, Beatriz [UNIFESP]Romariz, Simone [UNIFESP]Blanco, Miriam Marcela [UNIFESP]Vasconcelos, Juliana FragaBahia, LucianaPereira Soares, Milena BotelhoMello, Luiz E. [UNIFESP]Ribeiro-dos-Santos, Ricardo2016-01-24T14:05:14Z2016-01-24T14:05:14Z2010-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1628-1632http://dx.doi.org/10.1111/j.1528-1167.2010.02570.xEpilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 51, n. 8, p. 1628-1632, 2010.10.1111/j.1528-1167.2010.02570.x0013-9580http://repositorio.unifesp.br/handle/11600/32744WOS:000280669600033engEpilepsiainfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T12:05:14Zoai:repositorio.unifesp.br/:11600/32744Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T12:05:14Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
title Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
spellingShingle Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
Longo, Beatriz [UNIFESP]
Hippocampus
Chimeric mice
Microglia
Status epilepticus
GFP
title_short Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
title_full Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
title_fullStr Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
title_full_unstemmed Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
title_sort Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
author Longo, Beatriz [UNIFESP]
author_facet Longo, Beatriz [UNIFESP]
Romariz, Simone [UNIFESP]
Blanco, Miriam Marcela [UNIFESP]
Vasconcelos, Juliana Fraga
Bahia, Luciana
Pereira Soares, Milena Botelho
Mello, Luiz E. [UNIFESP]
Ribeiro-dos-Santos, Ricardo
author_role author
author2 Romariz, Simone [UNIFESP]
Blanco, Miriam Marcela [UNIFESP]
Vasconcelos, Juliana Fraga
Bahia, Luciana
Pereira Soares, Milena Botelho
Mello, Luiz E. [UNIFESP]
Ribeiro-dos-Santos, Ricardo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Hosp Sao Rafael
dc.contributor.author.fl_str_mv Longo, Beatriz [UNIFESP]
Romariz, Simone [UNIFESP]
Blanco, Miriam Marcela [UNIFESP]
Vasconcelos, Juliana Fraga
Bahia, Luciana
Pereira Soares, Milena Botelho
Mello, Luiz E. [UNIFESP]
Ribeiro-dos-Santos, Ricardo
dc.subject.por.fl_str_mv Hippocampus
Chimeric mice
Microglia
Status epilepticus
GFP
topic Hippocampus
Chimeric mice
Microglia
Status epilepticus
GFP
description P>The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP+ bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. the pattern of distribution, proliferation, and differentiation of GFP+ cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.
publishDate 2010
dc.date.none.fl_str_mv 2010-08-01
2016-01-24T14:05:14Z
2016-01-24T14:05:14Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/j.1528-1167.2010.02570.x
Epilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 51, n. 8, p. 1628-1632, 2010.
10.1111/j.1528-1167.2010.02570.x
0013-9580
http://repositorio.unifesp.br/handle/11600/32744
WOS:000280669600033
url http://dx.doi.org/10.1111/j.1528-1167.2010.02570.x
http://repositorio.unifesp.br/handle/11600/32744
identifier_str_mv Epilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 51, n. 8, p. 1628-1632, 2010.
10.1111/j.1528-1167.2010.02570.x
0013-9580
WOS:000280669600033
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Epilepsia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://olabout.wiley.com/WileyCDA/Section/id-406071.html
eu_rights_str_mv openAccess
rights_invalid_str_mv http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.format.none.fl_str_mv 1628-1632
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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