Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1378/chest.13-0622 http://repositorio.unifesp.br/handle/11600/37347 |
Resumo: | Background: Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. the aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) study population, to describe their main characteristics, and to determine the association of the COPD-asthma overlap group with exacerbations, hospitalizations, limitations due to physical health, and perception of general health status (GHS).Methods: the PLATINO study is a multicenter population-based survey carried out in five Latin American cities. Outcomes were self-reported exacerbations (defined by deterioration of breathing symptoms that affected usual daily activities or caused missed work), hospitalizations due to exacerbations, physical health limitations, and patients' perception of their GHS obtained by questionnaire. Subjects were classified in three specific groups: COPD-a postbronchodilator (post-BD) FEV1/FVC ratio of < 0.70; asthma-presence of wheezing in the last year and a minimum post-BD increase in FEV1 or FVC of 12% and 200 mL; and overlap COPD-asthma-the combination of the two.Results: Out of 5,044 subjects, 767 were classified as having COPD (12%), asthma (1.7%), and COPD-asthma overlap (1.8%). Subjects with COPD-asthma overlap had more respiratory symptoms, had worse lung function, used more respiratory medication, had more hospitalization and exacerbations, and had worse GHS. After adjusting for confounders, the COPD-asthma overlap was associated with higher risks for exacerbations (prevalence ratio [PR], 2.11; 95% CI, 1.08-4.12), hospitalizations (PR, 4.11; 95% CI, 1.45-11.67), and worse GHS (PR, 1.47; 95% CI, 1.18-1.85) compared with those with COPD.Conclusions: the coexisting COPD-asthma phenotype is possibly associated with increased disease severity. |
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Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-AsthmaBackground: Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. the aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) study population, to describe their main characteristics, and to determine the association of the COPD-asthma overlap group with exacerbations, hospitalizations, limitations due to physical health, and perception of general health status (GHS).Methods: the PLATINO study is a multicenter population-based survey carried out in five Latin American cities. Outcomes were self-reported exacerbations (defined by deterioration of breathing symptoms that affected usual daily activities or caused missed work), hospitalizations due to exacerbations, physical health limitations, and patients' perception of their GHS obtained by questionnaire. Subjects were classified in three specific groups: COPD-a postbronchodilator (post-BD) FEV1/FVC ratio of < 0.70; asthma-presence of wheezing in the last year and a minimum post-BD increase in FEV1 or FVC of 12% and 200 mL; and overlap COPD-asthma-the combination of the two.Results: Out of 5,044 subjects, 767 were classified as having COPD (12%), asthma (1.7%), and COPD-asthma overlap (1.8%). Subjects with COPD-asthma overlap had more respiratory symptoms, had worse lung function, used more respiratory medication, had more hospitalization and exacerbations, and had worse GHS. After adjusting for confounders, the COPD-asthma overlap was associated with higher risks for exacerbations (prevalence ratio [PR], 2.11; 95% CI, 1.08-4.12), hospitalizations (PR, 4.11; 95% CI, 1.45-11.67), and worse GHS (PR, 1.47; 95% CI, 1.18-1.85) compared with those with COPD.Conclusions: the coexisting COPD-asthma phenotype is possibly associated with increased disease severity.Univ Fed Pelotas, Postgrad Program Epidemiol, BR-96020220 Pelotas, RS, BrazilCent Univ Venezuela, Fac Med, Caracas, VenezuelaNatl Inst Resp Dis, Sleep Clin & Pulm Physiol, Mexico City, DF, MexicoGlaxoSmithKline, London, EnglandUniv Republica, Fac Med, Montevideo, UruguayCtr Hosp Pereira Rossell, Montevideo, UruguayUniversidade Federal de São Paulo, São Paulo, BrazilPontificia Univ Catolica Chile, Santiago, ChileUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of ScienceBoehringer Ingelheim GmbHGlaxoSmithKlineAmer Coll Chest PhysiciansUniv Fed PelotasCent Univ VenezuelaNatl Inst Resp DisGlaxoSmithKlineUniv RepublicaCtr Hosp Pereira RossellUniversidade Federal de São Paulo (UNIFESP)Pontificia Univ Catolica ChileMenezes, Ana Maria B.Oca, Maria Montes dePerez-Padilla, RogelioNadeau, GilbertWehrmeister, Fernando CesarLopez-Varela, Maria VictorinaMuino, AdrianaJardim, Jose Roberto B. [UNIFESP]Valdivia, GonzaloTalamo, CarlosPLATINO Team2016-01-24T14:35:11Z2016-01-24T14:35:11Z2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion297-304http://dx.doi.org/10.1378/chest.13-0622Chest. Northbrook: Amer Coll Chest Physicians, v. 145, n. 2, p. 297-304, 2014.10.1378/chest.13-06220012-3692http://repositorio.unifesp.br/handle/11600/37347WOS:000330955100021engChestinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-02-15T10:56:36Zoai:repositorio.unifesp.br/:11600/37347Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-02-15T10:56:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma |
title |
Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma |
spellingShingle |
Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma Menezes, Ana Maria B. |
title_short |
Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma |
title_full |
Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma |
title_fullStr |
Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma |
title_full_unstemmed |
Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma |
title_sort |
Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma |
author |
Menezes, Ana Maria B. |
author_facet |
Menezes, Ana Maria B. Oca, Maria Montes de Perez-Padilla, Rogelio Nadeau, Gilbert Wehrmeister, Fernando Cesar Lopez-Varela, Maria Victorina Muino, Adriana Jardim, Jose Roberto B. [UNIFESP] Valdivia, Gonzalo Talamo, Carlos PLATINO Team |
author_role |
author |
author2 |
Oca, Maria Montes de Perez-Padilla, Rogelio Nadeau, Gilbert Wehrmeister, Fernando Cesar Lopez-Varela, Maria Victorina Muino, Adriana Jardim, Jose Roberto B. [UNIFESP] Valdivia, Gonzalo Talamo, Carlos PLATINO Team |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Fed Pelotas Cent Univ Venezuela Natl Inst Resp Dis GlaxoSmithKline Univ Republica Ctr Hosp Pereira Rossell Universidade Federal de São Paulo (UNIFESP) Pontificia Univ Catolica Chile |
dc.contributor.author.fl_str_mv |
Menezes, Ana Maria B. Oca, Maria Montes de Perez-Padilla, Rogelio Nadeau, Gilbert Wehrmeister, Fernando Cesar Lopez-Varela, Maria Victorina Muino, Adriana Jardim, Jose Roberto B. [UNIFESP] Valdivia, Gonzalo Talamo, Carlos PLATINO Team |
description |
Background: Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. the aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) study population, to describe their main characteristics, and to determine the association of the COPD-asthma overlap group with exacerbations, hospitalizations, limitations due to physical health, and perception of general health status (GHS).Methods: the PLATINO study is a multicenter population-based survey carried out in five Latin American cities. Outcomes were self-reported exacerbations (defined by deterioration of breathing symptoms that affected usual daily activities or caused missed work), hospitalizations due to exacerbations, physical health limitations, and patients' perception of their GHS obtained by questionnaire. Subjects were classified in three specific groups: COPD-a postbronchodilator (post-BD) FEV1/FVC ratio of < 0.70; asthma-presence of wheezing in the last year and a minimum post-BD increase in FEV1 or FVC of 12% and 200 mL; and overlap COPD-asthma-the combination of the two.Results: Out of 5,044 subjects, 767 were classified as having COPD (12%), asthma (1.7%), and COPD-asthma overlap (1.8%). Subjects with COPD-asthma overlap had more respiratory symptoms, had worse lung function, used more respiratory medication, had more hospitalization and exacerbations, and had worse GHS. After adjusting for confounders, the COPD-asthma overlap was associated with higher risks for exacerbations (prevalence ratio [PR], 2.11; 95% CI, 1.08-4.12), hospitalizations (PR, 4.11; 95% CI, 1.45-11.67), and worse GHS (PR, 1.47; 95% CI, 1.18-1.85) compared with those with COPD.Conclusions: the coexisting COPD-asthma phenotype is possibly associated with increased disease severity. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02-01 2016-01-24T14:35:11Z 2016-01-24T14:35:11Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1378/chest.13-0622 Chest. Northbrook: Amer Coll Chest Physicians, v. 145, n. 2, p. 297-304, 2014. 10.1378/chest.13-0622 0012-3692 http://repositorio.unifesp.br/handle/11600/37347 WOS:000330955100021 |
url |
http://dx.doi.org/10.1378/chest.13-0622 http://repositorio.unifesp.br/handle/11600/37347 |
identifier_str_mv |
Chest. Northbrook: Amer Coll Chest Physicians, v. 145, n. 2, p. 297-304, 2014. 10.1378/chest.13-0622 0012-3692 WOS:000330955100021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chest |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
297-304 |
dc.publisher.none.fl_str_mv |
Amer Coll Chest Physicians |
publisher.none.fl_str_mv |
Amer Coll Chest Physicians |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268334118535168 |