Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma

Detalhes bibliográficos
Autor(a) principal: Menezes, Ana Maria B.
Data de Publicação: 2014
Outros Autores: Oca, Maria Montes de, Perez-Padilla, Rogelio, Nadeau, Gilbert, Wehrmeister, Fernando Cesar, Lopez-Varela, Maria Victorina, Muino, Adriana, Jardim, Jose Roberto B. [UNIFESP], Valdivia, Gonzalo, Talamo, Carlos, PLATINO Team
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1378/chest.13-0622
http://repositorio.unifesp.br/handle/11600/37347
Resumo: Background: Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. the aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) study population, to describe their main characteristics, and to determine the association of the COPD-asthma overlap group with exacerbations, hospitalizations, limitations due to physical health, and perception of general health status (GHS).Methods: the PLATINO study is a multicenter population-based survey carried out in five Latin American cities. Outcomes were self-reported exacerbations (defined by deterioration of breathing symptoms that affected usual daily activities or caused missed work), hospitalizations due to exacerbations, physical health limitations, and patients' perception of their GHS obtained by questionnaire. Subjects were classified in three specific groups: COPD-a postbronchodilator (post-BD) FEV1/FVC ratio of < 0.70; asthma-presence of wheezing in the last year and a minimum post-BD increase in FEV1 or FVC of 12% and 200 mL; and overlap COPD-asthma-the combination of the two.Results: Out of 5,044 subjects, 767 were classified as having COPD (12%), asthma (1.7%), and COPD-asthma overlap (1.8%). Subjects with COPD-asthma overlap had more respiratory symptoms, had worse lung function, used more respiratory medication, had more hospitalization and exacerbations, and had worse GHS. After adjusting for confounders, the COPD-asthma overlap was associated with higher risks for exacerbations (prevalence ratio [PR], 2.11; 95% CI, 1.08-4.12), hospitalizations (PR, 4.11; 95% CI, 1.45-11.67), and worse GHS (PR, 1.47; 95% CI, 1.18-1.85) compared with those with COPD.Conclusions: the coexisting COPD-asthma phenotype is possibly associated with increased disease severity.
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spelling Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-AsthmaBackground: Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. the aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) study population, to describe their main characteristics, and to determine the association of the COPD-asthma overlap group with exacerbations, hospitalizations, limitations due to physical health, and perception of general health status (GHS).Methods: the PLATINO study is a multicenter population-based survey carried out in five Latin American cities. Outcomes were self-reported exacerbations (defined by deterioration of breathing symptoms that affected usual daily activities or caused missed work), hospitalizations due to exacerbations, physical health limitations, and patients' perception of their GHS obtained by questionnaire. Subjects were classified in three specific groups: COPD-a postbronchodilator (post-BD) FEV1/FVC ratio of < 0.70; asthma-presence of wheezing in the last year and a minimum post-BD increase in FEV1 or FVC of 12% and 200 mL; and overlap COPD-asthma-the combination of the two.Results: Out of 5,044 subjects, 767 were classified as having COPD (12%), asthma (1.7%), and COPD-asthma overlap (1.8%). Subjects with COPD-asthma overlap had more respiratory symptoms, had worse lung function, used more respiratory medication, had more hospitalization and exacerbations, and had worse GHS. After adjusting for confounders, the COPD-asthma overlap was associated with higher risks for exacerbations (prevalence ratio [PR], 2.11; 95% CI, 1.08-4.12), hospitalizations (PR, 4.11; 95% CI, 1.45-11.67), and worse GHS (PR, 1.47; 95% CI, 1.18-1.85) compared with those with COPD.Conclusions: the coexisting COPD-asthma phenotype is possibly associated with increased disease severity.Univ Fed Pelotas, Postgrad Program Epidemiol, BR-96020220 Pelotas, RS, BrazilCent Univ Venezuela, Fac Med, Caracas, VenezuelaNatl Inst Resp Dis, Sleep Clin & Pulm Physiol, Mexico City, DF, MexicoGlaxoSmithKline, London, EnglandUniv Republica, Fac Med, Montevideo, UruguayCtr Hosp Pereira Rossell, Montevideo, UruguayUniversidade Federal de São Paulo, São Paulo, BrazilPontificia Univ Catolica Chile, Santiago, ChileUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of ScienceBoehringer Ingelheim GmbHGlaxoSmithKlineAmer Coll Chest PhysiciansUniv Fed PelotasCent Univ VenezuelaNatl Inst Resp DisGlaxoSmithKlineUniv RepublicaCtr Hosp Pereira RossellUniversidade Federal de São Paulo (UNIFESP)Pontificia Univ Catolica ChileMenezes, Ana Maria B.Oca, Maria Montes dePerez-Padilla, RogelioNadeau, GilbertWehrmeister, Fernando CesarLopez-Varela, Maria VictorinaMuino, AdrianaJardim, Jose Roberto B. [UNIFESP]Valdivia, GonzaloTalamo, CarlosPLATINO Team2016-01-24T14:35:11Z2016-01-24T14:35:11Z2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion297-304http://dx.doi.org/10.1378/chest.13-0622Chest. Northbrook: Amer Coll Chest Physicians, v. 145, n. 2, p. 297-304, 2014.10.1378/chest.13-06220012-3692http://repositorio.unifesp.br/handle/11600/37347WOS:000330955100021engChestinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-02-15T10:56:36Zoai:repositorio.unifesp.br/:11600/37347Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-02-15T10:56:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
title Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
spellingShingle Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
Menezes, Ana Maria B.
title_short Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
title_full Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
title_fullStr Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
title_full_unstemmed Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
title_sort Increased Risk of Exacerbation and Hospitalization in Subjects With an Overlap Phenotype COPD-Asthma
author Menezes, Ana Maria B.
author_facet Menezes, Ana Maria B.
Oca, Maria Montes de
Perez-Padilla, Rogelio
Nadeau, Gilbert
Wehrmeister, Fernando Cesar
Lopez-Varela, Maria Victorina
Muino, Adriana
Jardim, Jose Roberto B. [UNIFESP]
Valdivia, Gonzalo
Talamo, Carlos
PLATINO Team
author_role author
author2 Oca, Maria Montes de
Perez-Padilla, Rogelio
Nadeau, Gilbert
Wehrmeister, Fernando Cesar
Lopez-Varela, Maria Victorina
Muino, Adriana
Jardim, Jose Roberto B. [UNIFESP]
Valdivia, Gonzalo
Talamo, Carlos
PLATINO Team
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Fed Pelotas
Cent Univ Venezuela
Natl Inst Resp Dis
GlaxoSmithKline
Univ Republica
Ctr Hosp Pereira Rossell
Universidade Federal de São Paulo (UNIFESP)
Pontificia Univ Catolica Chile
dc.contributor.author.fl_str_mv Menezes, Ana Maria B.
Oca, Maria Montes de
Perez-Padilla, Rogelio
Nadeau, Gilbert
Wehrmeister, Fernando Cesar
Lopez-Varela, Maria Victorina
Muino, Adriana
Jardim, Jose Roberto B. [UNIFESP]
Valdivia, Gonzalo
Talamo, Carlos
PLATINO Team
description Background: Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. the aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) study population, to describe their main characteristics, and to determine the association of the COPD-asthma overlap group with exacerbations, hospitalizations, limitations due to physical health, and perception of general health status (GHS).Methods: the PLATINO study is a multicenter population-based survey carried out in five Latin American cities. Outcomes were self-reported exacerbations (defined by deterioration of breathing symptoms that affected usual daily activities or caused missed work), hospitalizations due to exacerbations, physical health limitations, and patients' perception of their GHS obtained by questionnaire. Subjects were classified in three specific groups: COPD-a postbronchodilator (post-BD) FEV1/FVC ratio of < 0.70; asthma-presence of wheezing in the last year and a minimum post-BD increase in FEV1 or FVC of 12% and 200 mL; and overlap COPD-asthma-the combination of the two.Results: Out of 5,044 subjects, 767 were classified as having COPD (12%), asthma (1.7%), and COPD-asthma overlap (1.8%). Subjects with COPD-asthma overlap had more respiratory symptoms, had worse lung function, used more respiratory medication, had more hospitalization and exacerbations, and had worse GHS. After adjusting for confounders, the COPD-asthma overlap was associated with higher risks for exacerbations (prevalence ratio [PR], 2.11; 95% CI, 1.08-4.12), hospitalizations (PR, 4.11; 95% CI, 1.45-11.67), and worse GHS (PR, 1.47; 95% CI, 1.18-1.85) compared with those with COPD.Conclusions: the coexisting COPD-asthma phenotype is possibly associated with increased disease severity.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-01
2016-01-24T14:35:11Z
2016-01-24T14:35:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1378/chest.13-0622
Chest. Northbrook: Amer Coll Chest Physicians, v. 145, n. 2, p. 297-304, 2014.
10.1378/chest.13-0622
0012-3692
http://repositorio.unifesp.br/handle/11600/37347
WOS:000330955100021
url http://dx.doi.org/10.1378/chest.13-0622
http://repositorio.unifesp.br/handle/11600/37347
identifier_str_mv Chest. Northbrook: Amer Coll Chest Physicians, v. 145, n. 2, p. 297-304, 2014.
10.1378/chest.13-0622
0012-3692
WOS:000330955100021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Chest
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 297-304
dc.publisher.none.fl_str_mv Amer Coll Chest Physicians
publisher.none.fl_str_mv Amer Coll Chest Physicians
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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