Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/1300 http://dx.doi.org/10.1590/S0100-879X2001001200013 |
Resumo: | The role of the caudal pressor area (CPA) in the maintenance of vasomotor tonus in anesthetized and decerebrate animals has been clearly established. In conscious animals, however, the participation of CPA in the cardiovascular control remains to be fully elucidated. In the present study, unilateral L-glutamate (L-Glu) (10 and/or 20 nmol/70 nl) microinjection into CPA, in conscious male Wistar rats (250-280 g) caused a significant increase in mean arterial blood pressure (MAP; control: 112 ± 1.9 mmHg; after 20 nmol L-Glu: 139 ± 4.5 mmHg, N = 12, P<0.05) and respiratory rate (control: 81 ± 3.5 breaths/min; after 10 nmol L-Glu: 92 ± 3 breaths/min, P<0.05; after 20 nmol L-Glu: 104 ± 5 breaths/min, N = 6, P<0.05). The subsequent anesthesia with urethane caused a significant increase in basal respiratory frequency (conscious: 81 ± 3.5 breaths/min; under urethane: 107 ± 1.3 breaths/min, N = 6, P<0.05). Anesthesia also significantly attenuated L-Glu-evoked pressor (conscious: deltaMAP = +27 mmHg; anesthetized: deltaMAP = +18 mmHg, P<0.05) and respiratory responses. These results suggest that glutamatergic receptors in the CPA are involved in cardiovascular and respiratory modulation in conscious rats. |
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Silva, N.f.Pires, J.g.p.Campos, Ruy Ribeiro [UNIFESP]Futuro Neto, H.a.Universidade Federal do Espírito Santo Centro Biomédico Departamento de Ciências FisiológicasFAESA Faculdade de Saúde de VitóriaUniversidade Federal de São Paulo (UNIFESP)2015-06-14T13:29:33Z2015-06-14T13:29:33Z2001-12-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 12, p. 1603-1606, 2001.0100-879Xhttp://repositorio.unifesp.br/handle/11600/1300http://dx.doi.org/10.1590/S0100-879X2001001200013S0100-879X2001001200013.pdfS0100-879X200100120001310.1590/S0100-879X2001001200013WOS:000172765500013The role of the caudal pressor area (CPA) in the maintenance of vasomotor tonus in anesthetized and decerebrate animals has been clearly established. In conscious animals, however, the participation of CPA in the cardiovascular control remains to be fully elucidated. In the present study, unilateral L-glutamate (L-Glu) (10 and/or 20 nmol/70 nl) microinjection into CPA, in conscious male Wistar rats (250-280 g) caused a significant increase in mean arterial blood pressure (MAP; control: 112 ± 1.9 mmHg; after 20 nmol L-Glu: 139 ± 4.5 mmHg, N = 12, P<0.05) and respiratory rate (control: 81 ± 3.5 breaths/min; after 10 nmol L-Glu: 92 ± 3 breaths/min, P<0.05; after 20 nmol L-Glu: 104 ± 5 breaths/min, N = 6, P<0.05). The subsequent anesthesia with urethane caused a significant increase in basal respiratory frequency (conscious: 81 ± 3.5 breaths/min; under urethane: 107 ± 1.3 breaths/min, N = 6, P<0.05). Anesthesia also significantly attenuated L-Glu-evoked pressor (conscious: deltaMAP = +27 mmHg; anesthetized: deltaMAP = +18 mmHg, P<0.05) and respiratory responses. These results suggest that glutamatergic receptors in the CPA are involved in cardiovascular and respiratory modulation in conscious rats.Universidade Federal do Espírito Santo Centro Biomédico Departamento de Ciências FisiológicasFAESA Faculdade de Saúde de VitóriaUniversidade Federal de São Paulo (UNIFESP) Disciplina de Fisiologia CardiovascularUNIFESP, Disciplina de Fisiologia CardiovascularSciELO1603-1606engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Researchcaudal pressor areaventrolateral medullablood pressureL-glutamaterespirationCardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2001001200013.pdfapplication/pdf64591${dspace.ui.url}/bitstream/11600/1300/1/S0100-879X2001001200013.pdf2c3ae14e9ff2a432077b56098f47fe80MD51open accessTEXTS0100-879X2001001200013.pdf.txtS0100-879X2001001200013.pdf.txtExtracted texttext/plain13278${dspace.ui.url}/bitstream/11600/1300/2/S0100-879X2001001200013.pdf.txtbdf9f749f23df3bea13e1b2eb5a4c908MD52open access11600/13002021-09-30 17:25:18.164open accessoai:repositorio.unifesp.br:11600/1300Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:26:04.516843Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats |
title |
Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats |
spellingShingle |
Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats Silva, N.f. caudal pressor area ventrolateral medulla blood pressure L-glutamate respiration |
title_short |
Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats |
title_full |
Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats |
title_fullStr |
Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats |
title_full_unstemmed |
Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats |
title_sort |
Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats |
author |
Silva, N.f. |
author_facet |
Silva, N.f. Pires, J.g.p. Campos, Ruy Ribeiro [UNIFESP] Futuro Neto, H.a. |
author_role |
author |
author2 |
Pires, J.g.p. Campos, Ruy Ribeiro [UNIFESP] Futuro Neto, H.a. |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal do Espírito Santo Centro Biomédico Departamento de Ciências Fisiológicas FAESA Faculdade de Saúde de Vitória Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Silva, N.f. Pires, J.g.p. Campos, Ruy Ribeiro [UNIFESP] Futuro Neto, H.a. |
dc.subject.eng.fl_str_mv |
caudal pressor area ventrolateral medulla blood pressure L-glutamate respiration |
topic |
caudal pressor area ventrolateral medulla blood pressure L-glutamate respiration |
description |
The role of the caudal pressor area (CPA) in the maintenance of vasomotor tonus in anesthetized and decerebrate animals has been clearly established. In conscious animals, however, the participation of CPA in the cardiovascular control remains to be fully elucidated. In the present study, unilateral L-glutamate (L-Glu) (10 and/or 20 nmol/70 nl) microinjection into CPA, in conscious male Wistar rats (250-280 g) caused a significant increase in mean arterial blood pressure (MAP; control: 112 ± 1.9 mmHg; after 20 nmol L-Glu: 139 ± 4.5 mmHg, N = 12, P<0.05) and respiratory rate (control: 81 ± 3.5 breaths/min; after 10 nmol L-Glu: 92 ± 3 breaths/min, P<0.05; after 20 nmol L-Glu: 104 ± 5 breaths/min, N = 6, P<0.05). The subsequent anesthesia with urethane caused a significant increase in basal respiratory frequency (conscious: 81 ± 3.5 breaths/min; under urethane: 107 ± 1.3 breaths/min, N = 6, P<0.05). Anesthesia also significantly attenuated L-Glu-evoked pressor (conscious: deltaMAP = +27 mmHg; anesthetized: deltaMAP = +18 mmHg, P<0.05) and respiratory responses. These results suggest that glutamatergic receptors in the CPA are involved in cardiovascular and respiratory modulation in conscious rats. |
publishDate |
2001 |
dc.date.issued.fl_str_mv |
2001-12-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:29:33Z |
dc.date.available.fl_str_mv |
2015-06-14T13:29:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 12, p. 1603-1606, 2001. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/1300 http://dx.doi.org/10.1590/S0100-879X2001001200013 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2001001200013.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2001001200013 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2001001200013 |
dc.identifier.wos.none.fl_str_mv |
WOS:000172765500013 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 12, p. 1603-1606, 2001. 0100-879X S0100-879X2001001200013.pdf S0100-879X2001001200013 10.1590/S0100-879X2001001200013 WOS:000172765500013 |
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http://repositorio.unifesp.br/handle/11600/1300 http://dx.doi.org/10.1590/S0100-879X2001001200013 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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