A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/43196 http://rheumatology.oxfordjournals.org/content/35/2/150.abstract |
Resumo: | Thirty-eight patients with rheumatoid arthritis meeting American College of Rheumatism (ACR) criteria were entered in a randomized controlled trial (RCT) of 6 months to assess whether monthly treatment with i.v. methylprednisolone (MP) enhances or accelerates the efficacy of sulphasalazine (SSZ). All patients had failed at least one second-line agent and were randomized to receive SSZ (2 g/day) and pulses of MP (5 mg/kg), or SSZ (2 g/day) and pulses of saline (SA). A single infusion of 2 h was carried out in both groups for a total of three times (0, 1 and 2 months). The two groups were comparable at baseline regarding their demographic and clinical characteristics. Disease activity was evaluated every 2 months by means of: (1) joint count; (2) morning stiffness; (3) grip strength;(4) visual analogue pain score; (5) health assessment questionnaire; and (6) erythrocyte sedimentation rate. All outcome measures improved significantly in both groups (P < 0.001). Evaluation at each follow-up visit showed no significant differences between the groups in any of the adverse effects attributable to SSZ therapy (one SA vs two MP). Adverse effects attributable to SA/MP therapy were rare and mild. We concluded that repeated pulses of MP during the first 3 months of treatment did not improve the efficacy of SSZ. Therefore, there is no justification for using MP in this way during the induction phase of SSZ therapy. |
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Ciconelli, Rozana Mesquita [UNIFESP]Ferraz,Marcos Bosi [UNIFESP]Visioni, R. A.Oliveira, L. M.Atra, Edgard [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2018-06-15T16:39:07Z2018-06-15T16:39:07Z1996-02-01British Journal Of Rheumatology. Oxford: Oxford Univ Press United Kingdom, v. 35, n. 2, p. 150-154, 1996.0263-7103http://repositorio.unifesp.br/11600/43196http://rheumatology.oxfordjournals.org/content/35/2/150.abstractWOS:A1996UD88700012Thirty-eight patients with rheumatoid arthritis meeting American College of Rheumatism (ACR) criteria were entered in a randomized controlled trial (RCT) of 6 months to assess whether monthly treatment with i.v. methylprednisolone (MP) enhances or accelerates the efficacy of sulphasalazine (SSZ). All patients had failed at least one second-line agent and were randomized to receive SSZ (2 g/day) and pulses of MP (5 mg/kg), or SSZ (2 g/day) and pulses of saline (SA). A single infusion of 2 h was carried out in both groups for a total of three times (0, 1 and 2 months). The two groups were comparable at baseline regarding their demographic and clinical characteristics. Disease activity was evaluated every 2 months by means of: (1) joint count; (2) morning stiffness; (3) grip strength;(4) visual analogue pain score; (5) health assessment questionnaire; and (6) erythrocyte sedimentation rate. All outcome measures improved significantly in both groups (P < 0.001). Evaluation at each follow-up visit showed no significant differences between the groups in any of the adverse effects attributable to SSZ therapy (one SA vs two MP). Adverse effects attributable to SA/MP therapy were rare and mild. We concluded that repeated pulses of MP during the first 3 months of treatment did not improve the efficacy of SSZ. Therefore, there is no justification for using MP in this way during the induction phase of SSZ therapy.ESCOLA PAULISTA MED,DISCIPLINE REUMATOL,DEPT MED,DIV RHEUMATOL,RUA BOTUCATU 740,BR-04023062 SAO PAULO,BRAZILESCOLA PAULISTA MED,DISCIPLINE REUMATOL,DEPT MED,DIV RHEUMATOL,RUA BOTUCATU 740,BR-04023062 SAO PAULO,BRAZILWeb of Science150-154engOxford Univ Press United KingdomBritish Journal Of Rheumatologyhttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.htmlinfo:eu-repo/semantics/openAccesssulphasalazinemethylprednisolonecombination therapyrheumatoid arthritisA randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/431962021-10-04 21:23:54.797metadata only accessoai:repositorio.unifesp.br:11600/43196Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:24:28.422918Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis |
title |
A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis |
spellingShingle |
A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis Ciconelli, Rozana Mesquita [UNIFESP] sulphasalazine methylprednisolone combination therapy rheumatoid arthritis |
title_short |
A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis |
title_full |
A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis |
title_fullStr |
A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis |
title_full_unstemmed |
A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis |
title_sort |
A randomized double-blind controlled trial of sulphasalazine combined with pulses of methylprednisolone or placebo in the treatment of rheumatoid arthritis |
author |
Ciconelli, Rozana Mesquita [UNIFESP] |
author_facet |
Ciconelli, Rozana Mesquita [UNIFESP] Ferraz,Marcos Bosi [UNIFESP] Visioni, R. A. Oliveira, L. M. Atra, Edgard [UNIFESP] |
author_role |
author |
author2 |
Ferraz,Marcos Bosi [UNIFESP] Visioni, R. A. Oliveira, L. M. Atra, Edgard [UNIFESP] |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Ciconelli, Rozana Mesquita [UNIFESP] Ferraz,Marcos Bosi [UNIFESP] Visioni, R. A. Oliveira, L. M. Atra, Edgard [UNIFESP] |
dc.subject.eng.fl_str_mv |
sulphasalazine methylprednisolone combination therapy rheumatoid arthritis |
topic |
sulphasalazine methylprednisolone combination therapy rheumatoid arthritis |
description |
Thirty-eight patients with rheumatoid arthritis meeting American College of Rheumatism (ACR) criteria were entered in a randomized controlled trial (RCT) of 6 months to assess whether monthly treatment with i.v. methylprednisolone (MP) enhances or accelerates the efficacy of sulphasalazine (SSZ). All patients had failed at least one second-line agent and were randomized to receive SSZ (2 g/day) and pulses of MP (5 mg/kg), or SSZ (2 g/day) and pulses of saline (SA). A single infusion of 2 h was carried out in both groups for a total of three times (0, 1 and 2 months). The two groups were comparable at baseline regarding their demographic and clinical characteristics. Disease activity was evaluated every 2 months by means of: (1) joint count; (2) morning stiffness; (3) grip strength;(4) visual analogue pain score; (5) health assessment questionnaire; and (6) erythrocyte sedimentation rate. All outcome measures improved significantly in both groups (P < 0.001). Evaluation at each follow-up visit showed no significant differences between the groups in any of the adverse effects attributable to SSZ therapy (one SA vs two MP). Adverse effects attributable to SA/MP therapy were rare and mild. We concluded that repeated pulses of MP during the first 3 months of treatment did not improve the efficacy of SSZ. Therefore, there is no justification for using MP in this way during the induction phase of SSZ therapy. |
publishDate |
1996 |
dc.date.issued.fl_str_mv |
1996-02-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T16:39:07Z |
dc.date.available.fl_str_mv |
2018-06-15T16:39:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
British Journal Of Rheumatology. Oxford: Oxford Univ Press United Kingdom, v. 35, n. 2, p. 150-154, 1996. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/43196 http://rheumatology.oxfordjournals.org/content/35/2/150.abstract |
dc.identifier.issn.none.fl_str_mv |
0263-7103 |
dc.identifier.wos.none.fl_str_mv |
WOS:A1996UD88700012 |
identifier_str_mv |
British Journal Of Rheumatology. Oxford: Oxford Univ Press United Kingdom, v. 35, n. 2, p. 150-154, 1996. 0263-7103 WOS:A1996UD88700012 |
url |
http://repositorio.unifesp.br/11600/43196 http://rheumatology.oxfordjournals.org/content/35/2/150.abstract |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
British Journal Of Rheumatology |
dc.rights.driver.fl_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
150-154 |
dc.publisher.none.fl_str_mv |
Oxford Univ Press United Kingdom |
publisher.none.fl_str_mv |
Oxford Univ Press United Kingdom |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460286969151488 |