Síndrome vasoplégica: nova forma de síndrome pós perfusão

• Autor(a) principal: Gomes, Walter José [UNIFESP]
• Data de Publicação: 1996
• Outros Autores: Silas, Marcelo Grandini [UNIFESP], Lopes, Marly Garcia [UNIFESP], Fonseca, José Honório de Almeida Palma da [UNIFESP], Teles, Carlos Alberto [UNIFESP], Branco, João Nelson Rodrigues [UNIFESP], Carvalho, Antonio Carlos [UNIFESP], Buffolo, Enio [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0102-76381996000100008; http://repositorio.unifesp.br/handle/11600/410
• topic: Extracorporeal circulation; Postperfusion syndromes; Circulação extracorpórea; Síndromes pós perfusão

A new form of postperfusion syndrome, termed vasoplegic syndrome and presenting in the postoperative period of heart surgery with cardiopulmonary bypass (CPB) is described. The patients exhibit hipotension, normal or elevated cardiac output, low systemic vascular resistance and decreased filling pressures. Physical examination revealed normal capillary filling atthe extremities, but oliguria and hipotension. These patients needed a high dosage of vasoconstrictor drugs (norepinephrine) for blood pressure control and even high dose of norepinephrine did not produce the classical situation of cool extremities. Twelve patients who presented signals and symptoms of vasoplegic syndrome are shown. The characteristics of vasoplegic syndrome are similar to those observed in the septic shock. In sepsis, the alterations are mediated by cytokines and TNF-α. The appearance of vasoplegic syndrome augments operative morbidity, with an increased risk to the patient.