Síndrome de Cushing subclínica em populações de risco

• Autor(a) principal: Caetano, Maria Silvia S. [UNIFESP]
• Data de Publicação: 2007
• Outros Autores: Vilar, Lucio, Kater, Claudio Elias [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-27302007000800003; http://repositorio.unifesp.br/handle/11600/3983
• topic: Type 2 diabetes mellitus; Obesity; Overweight; Hypercortisolism; Cushing's syndrome; Subclinical Cushing's syndrome; Diabetes mellitus tipo 2; Obesidade; Sobrepeso; Hipercortisolismo; Síndrome de Cushing; Síndrome de Cushing subclínica

Based on autopsy studies, adrenal masses are among the most common tumors in humans. Endogenous Cushing's syndrome (CS) is unusual and adrenal adenomas account for 10% of all cases of CS. Patients with subclinical CS (SCS) present abnormal cortisol dynamics without obvious manifestations. The prevalence of hypercortisolism in clinically inapparent adrenal masses has been reported as 9%. Data from several small series of patients indicate that fewer than 20% develop hormone overproduction when followed for up to 10 years. Follow-up of patients with subclinical CS suggests that rarely masses increase in size or progress to overt CS. Adrenal incidentalomas and subclinical CS are related to metabolic disorders, in special to type-2 diabetes. The scarce available data suggest that treatment of hypercortisolism correct the metabolic abnormalities and blood pressure. Some studies evaluating the prevalence of subclinical CS in overweight type-2 diabetes patients suggest that it is considerably higher in populations at risk than in the general population.