Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors

Detalhes bibliográficos
Autor(a) principal: Heinke, Thais [UNIFESP]
Data de Publicação: 2013
Outros Autores: Espiríto Santo, Kleber Simões do, Longatto Filho, Adhemar, Stávale, João Norberto [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502013000100008
http://repositorio.unifesp.br/handle/11600/7540
Resumo: PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.
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spelling Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumorsGliomaNeovascularization, PathologicImmunohistochemistryPURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.UNIFESP-EPM Investigative Pathology DivisionClinical Hospital Luzia de Pinho MeloUniversity of São Paulo Faculty of Medicine Laboratory of Medical InvestigationUNIFESP, EPM, Investigative Pathology DivisionSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Federal de São Paulo (UNIFESP)Clinical Hospital Luzia de Pinho MeloUniversidade de São Paulo (USP)Heinke, Thais [UNIFESP]Espiríto Santo, Kleber Simões doLongatto Filho, AdhemarStávale, João Norberto [UNIFESP]2015-06-14T13:45:11Z2015-06-14T13:45:11Z2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion48-54application/pdfhttp://dx.doi.org/10.1590/S0102-86502013000100008Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 48-54, 2013.10.1590/S0102-86502013000100008S0102-86502013000100008.pdf0102-8650S0102-86502013000100008http://repositorio.unifesp.br/handle/11600/7540WOS:000313866600007engActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T20:33:42Zoai:repositorio.unifesp.br/:11600/7540Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T20:33:42Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
title Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
spellingShingle Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
Heinke, Thais [UNIFESP]
Glioma
Neovascularization, Pathologic
Immunohistochemistry
title_short Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
title_full Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
title_fullStr Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
title_full_unstemmed Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
title_sort Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
author Heinke, Thais [UNIFESP]
author_facet Heinke, Thais [UNIFESP]
Espiríto Santo, Kleber Simões do
Longatto Filho, Adhemar
Stávale, João Norberto [UNIFESP]
author_role author
author2 Espiríto Santo, Kleber Simões do
Longatto Filho, Adhemar
Stávale, João Norberto [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Clinical Hospital Luzia de Pinho Melo
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Heinke, Thais [UNIFESP]
Espiríto Santo, Kleber Simões do
Longatto Filho, Adhemar
Stávale, João Norberto [UNIFESP]
dc.subject.por.fl_str_mv Glioma
Neovascularization, Pathologic
Immunohistochemistry
topic Glioma
Neovascularization, Pathologic
Immunohistochemistry
description PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2015-06-14T13:45:11Z
2015-06-14T13:45:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502013000100008
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 48-54, 2013.
10.1590/S0102-86502013000100008
S0102-86502013000100008.pdf
0102-8650
S0102-86502013000100008
http://repositorio.unifesp.br/handle/11600/7540
WOS:000313866600007
url http://dx.doi.org/10.1590/S0102-86502013000100008
http://repositorio.unifesp.br/handle/11600/7540
identifier_str_mv Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 48-54, 2013.
10.1590/S0102-86502013000100008
S0102-86502013000100008.pdf
0102-8650
S0102-86502013000100008
WOS:000313866600007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 48-54
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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