Estudo da anemia em longevos com independência funcional

Detalhes bibliográficos
Autor(a) principal: Moraes, Niele Silva de [UNIFESP]
Data de Publicação: 2016
Tipo de documento: Tese
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=4194617
http://repositorio.unifesp.br/handle/11600/46712
Resumo: Lower levels of hemoglobin have been often observed in the elderly population, but it has been discussed whether anemia is a physiological consequence of aging or a negative clinical feature. Objetives: The aims of this study were to evaluate hemoglobin levels in a Brazilian population of oldest old with active aging; describe the prevalence and causes of anemia in this population and its impact on survival. Patients and Methods: This was a prospective observational study of community-dwelling independent elderly aged 80 years or older in the city of São Paulo, Brazil. Patients were excluded if institutionalized, diagnosed with dementia, Parkinson disease or current cancer, were under dialysis or were hospitalized in the last 3 months. Reference range of Hb levels was calculated e according to recommendations of the International Federation of Clinical Chemistry (IFCC). Results: Of 256 subjects included in this study, 182 (71%) were women, median age was 85 years old (80?99). A total of 47 individuals met exclusion criteria for statistical analysis. The median hemoglobin level was 13.9 g/dL in men and 13.3 g/dL in women. Calculated 0.95 reference range of hemoglobin concentration was 11.2-16.7g/dL for men and 11.3-15.7 g/dL in women. According to WHO criteria, 40 patients (15,6%) had anemia. The major cause of anemia was chronic kidney disease (CKD), present as single cause of anemia in 40.0% of patients. Iron deficiency was the second most common cause of anemia (37.5% of cases). Patients with anemia had significantly lower glomerular filtration rate (42.7ml/min/1.73m2 vs. 50.6 ml/min/1.73m2, P=0.001). There was a significant association between anemia and osteoporosis (P=0.045) and osteoarthritis (P<0.001). No difference in survival of patients with or without anemia was observed (74% vs. 84%, P=0.22). Conclusion: A lower threshold of hemoglobin was found for both men and women when compared to levels set by WHO. Most of cases of anemia were secondary to CKD, followed by iron deficiency. Anemia was not associated with inferior survival in functionally independent oldest old men or women. Further studies must contribute to indicate the normal level of hemoglobin concentration in the elderly and clarify if anemia is actually a marker of other clinical conditions that may impact on survival of the elderly population. contribute to indicate the normal level of hemoglobin concentration in the elderly.
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spelling Estudo da anemia em longevos com independência funcionalStudy of anemia in oldest old functionally independentElderlyHemoglobinAnemiaPrevalenceIdososHemoglobinaAnemiaPrevalênciaLower levels of hemoglobin have been often observed in the elderly population, but it has been discussed whether anemia is a physiological consequence of aging or a negative clinical feature. Objetives: The aims of this study were to evaluate hemoglobin levels in a Brazilian population of oldest old with active aging; describe the prevalence and causes of anemia in this population and its impact on survival. Patients and Methods: This was a prospective observational study of community-dwelling independent elderly aged 80 years or older in the city of São Paulo, Brazil. Patients were excluded if institutionalized, diagnosed with dementia, Parkinson disease or current cancer, were under dialysis or were hospitalized in the last 3 months. Reference range of Hb levels was calculated e according to recommendations of the International Federation of Clinical Chemistry (IFCC). Results: Of 256 subjects included in this study, 182 (71%) were women, median age was 85 years old (80?99). A total of 47 individuals met exclusion criteria for statistical analysis. The median hemoglobin level was 13.9 g/dL in men and 13.3 g/dL in women. Calculated 0.95 reference range of hemoglobin concentration was 11.2-16.7g/dL for men and 11.3-15.7 g/dL in women. According to WHO criteria, 40 patients (15,6%) had anemia. The major cause of anemia was chronic kidney disease (CKD), present as single cause of anemia in 40.0% of patients. Iron deficiency was the second most common cause of anemia (37.5% of cases). Patients with anemia had significantly lower glomerular filtration rate (42.7ml/min/1.73m2 vs. 50.6 ml/min/1.73m2, P=0.001). There was a significant association between anemia and osteoporosis (P=0.045) and osteoarthritis (P<0.001). No difference in survival of patients with or without anemia was observed (74% vs. 84%, P=0.22). Conclusion: A lower threshold of hemoglobin was found for both men and women when compared to levels set by WHO. Most of cases of anemia were secondary to CKD, followed by iron deficiency. Anemia was not associated with inferior survival in functionally independent oldest old men or women. Further studies must contribute to indicate the normal level of hemoglobin concentration in the elderly and clarify if anemia is actually a marker of other clinical conditions that may impact on survival of the elderly population. contribute to indicate the normal level of hemoglobin concentration in the elderly.Introdução: Baixos níveis de hemoglobina (Hb) são frequentemente observados em idosos, porém discute-se se anemia é uma consequência fisiológica do envelhecimento ou uma característica clínica associada a desfechos negativos. Objetivos: Avaliar os níveis de Hb em uma população de longevos com envelhecimento ativo; descrever a prevalência e causas de anemia nessa população e avaliar o impacto da anemia na sobrevida desses indivíduos. Pacientes e métodos: Estudo prospectivo observacional com idosos da comunidade com 80 anos ou mais, na cidade de São Paulo, Brasil. Foram excluídos pacientes institucionalizados; com diagnóstico de demência, doença de Parkinson ou câncer atual; doenças crônicas descompensadas, submetidos a diálise ou hospitalizados nos últimos 3 meses. Intervalos de referência dos níveis de Hb foram calculados de acordo com as recomendações da Federação Internacional de Química Clínica (IFCC). Resultados: Dos 256 longevos incluídos no estudo, 182 (71%) eram mulheres, idade mediana de 85 anos (80-99). A mediana de Hb foi 13.9 g/dL em homens e 13.3 g/dL em mulheres. O intervalo de confiança de 0.95 da concentração de Hb foi 11.2-16.7g/dL para homens e 11.3-15.7 g/dL para mulheres. De acordo com os critérios da OMS, 40 pacientes tinham anemia (15.6%). A principal causa de anemia foi associada a doença renal crônica (DRC), presente como causa única em 40% dos casos de anemia. Deficiência de ferro foi a segunda causa mais frequente (37.5% dos casos). Pacientes com anemia tiveram significativamente menores taxas de filtração glomerular (42.7ml/min/1.73m2 vs. 50.6 ml/min/1.73m2, P=0.001). Não foi observada diferença de sobrevida em pacientes com e sem anemia (74% vs. 84%, P=0.22). Conclusões: Foram encontrados menores limites de normalidade dos níveis de Hb na população estudada do que os propostos pela OMS. A maioria dos casos de anemia foi secundária a DRC, seguido por deficiência de ferro. Anemia não foi associada a menor sobrevida em idosos com independência funcional. Outros estudos são necessários para esclarecer os níveis normais de Hb em longevos e se anemia é um marcador de outras condições clínicas que podem apresentar impacto na sobrevida da população idosa.Dados abertos - Sucupira - Teses e dissertações (2013 a 2016)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2013/12161-9Universidade Federal de São Paulo (UNIFESP)Figueiredo, Maria Stella Figueiredo [UNIFESP]http://lattes.cnpq.br/0736747630522639http://lattes.cnpq.br/1140706468939596Universidade Federal de São Paulo (UNIFESP)Moraes, Niele Silva de [UNIFESP]2018-07-27T15:50:44Z2018-07-27T15:50:44Z2016-11-29info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion120 f.application/pdfhttps://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=4194617MORAES, Niele Silva de. Estudo da anemia em longevos com independência funcional. 2016. 120 f. Tese (Doutorado em Medicina: Hematologia) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2016.Niele Silva de Moraes - PDF A.pdfhttp://repositorio.unifesp.br/handle/11600/46712porSão Pauloinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T09:01:21Zoai:repositorio.unifesp.br/:11600/46712Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T09:01:21Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Estudo da anemia em longevos com independência funcional
Study of anemia in oldest old functionally independent
title Estudo da anemia em longevos com independência funcional
spellingShingle Estudo da anemia em longevos com independência funcional
Moraes, Niele Silva de [UNIFESP]
Elderly
Hemoglobin
Anemia
Prevalence
Idosos
Hemoglobina
Anemia
Prevalência
title_short Estudo da anemia em longevos com independência funcional
title_full Estudo da anemia em longevos com independência funcional
title_fullStr Estudo da anemia em longevos com independência funcional
title_full_unstemmed Estudo da anemia em longevos com independência funcional
title_sort Estudo da anemia em longevos com independência funcional
author Moraes, Niele Silva de [UNIFESP]
author_facet Moraes, Niele Silva de [UNIFESP]
author_role author
dc.contributor.none.fl_str_mv Figueiredo, Maria Stella Figueiredo [UNIFESP]
http://lattes.cnpq.br/0736747630522639
http://lattes.cnpq.br/1140706468939596
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Moraes, Niele Silva de [UNIFESP]
dc.subject.por.fl_str_mv Elderly
Hemoglobin
Anemia
Prevalence
Idosos
Hemoglobina
Anemia
Prevalência
topic Elderly
Hemoglobin
Anemia
Prevalence
Idosos
Hemoglobina
Anemia
Prevalência
description Lower levels of hemoglobin have been often observed in the elderly population, but it has been discussed whether anemia is a physiological consequence of aging or a negative clinical feature. Objetives: The aims of this study were to evaluate hemoglobin levels in a Brazilian population of oldest old with active aging; describe the prevalence and causes of anemia in this population and its impact on survival. Patients and Methods: This was a prospective observational study of community-dwelling independent elderly aged 80 years or older in the city of São Paulo, Brazil. Patients were excluded if institutionalized, diagnosed with dementia, Parkinson disease or current cancer, were under dialysis or were hospitalized in the last 3 months. Reference range of Hb levels was calculated e according to recommendations of the International Federation of Clinical Chemistry (IFCC). Results: Of 256 subjects included in this study, 182 (71%) were women, median age was 85 years old (80?99). A total of 47 individuals met exclusion criteria for statistical analysis. The median hemoglobin level was 13.9 g/dL in men and 13.3 g/dL in women. Calculated 0.95 reference range of hemoglobin concentration was 11.2-16.7g/dL for men and 11.3-15.7 g/dL in women. According to WHO criteria, 40 patients (15,6%) had anemia. The major cause of anemia was chronic kidney disease (CKD), present as single cause of anemia in 40.0% of patients. Iron deficiency was the second most common cause of anemia (37.5% of cases). Patients with anemia had significantly lower glomerular filtration rate (42.7ml/min/1.73m2 vs. 50.6 ml/min/1.73m2, P=0.001). There was a significant association between anemia and osteoporosis (P=0.045) and osteoarthritis (P<0.001). No difference in survival of patients with or without anemia was observed (74% vs. 84%, P=0.22). Conclusion: A lower threshold of hemoglobin was found for both men and women when compared to levels set by WHO. Most of cases of anemia were secondary to CKD, followed by iron deficiency. Anemia was not associated with inferior survival in functionally independent oldest old men or women. Further studies must contribute to indicate the normal level of hemoglobin concentration in the elderly and clarify if anemia is actually a marker of other clinical conditions that may impact on survival of the elderly population. contribute to indicate the normal level of hemoglobin concentration in the elderly.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-29
2018-07-27T15:50:44Z
2018-07-27T15:50:44Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=4194617
MORAES, Niele Silva de. Estudo da anemia em longevos com independência funcional. 2016. 120 f. Tese (Doutorado em Medicina: Hematologia) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2016.
Niele Silva de Moraes - PDF A.pdf
http://repositorio.unifesp.br/handle/11600/46712
url https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=4194617
http://repositorio.unifesp.br/handle/11600/46712
identifier_str_mv MORAES, Niele Silva de. Estudo da anemia em longevos com independência funcional. 2016. 120 f. Tese (Doutorado em Medicina: Hematologia) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2016.
Niele Silva de Moraes - PDF A.pdf
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 120 f.
application/pdf
dc.coverage.none.fl_str_mv São Paulo
dc.publisher.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
publisher.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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