Expression and function of G-protein-coupled receptorsin the male reproductive tract

Detalhes bibliográficos
Autor(a) principal: Avellar, Maria Christina Werneck [UNIFESP]
Data de Publicação: 2009
Outros Autores: Lazari, Maria de Fatima Magalhaes [UNIFESP], Porto, Catarina Segreti [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0001-37652009000300002
http://repositorio.unifesp.br/handle/11600/5195
Resumo: This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract. The localization and differential expression of mAChR and α1-adrenoceptor subtypes in specific compartments of the efferent ductules, epididymis, vas deferens, seminal vesicle and prostate of various species indicate a role for these receptors in the modulation of luminal fluid composition and smooth muscle contraction, including effects on male fertility. Furthermore, the activation of mAChRs induces transactivation of the epidermal growth factor receptor (EGFR) and the Sertoli cell proliferation. The relaxin receptors are present in the testis, RXFP1 in elongated spermatids and Sertoli cells from rat, and RXFP2 in Leydig and germ cells from rat and human, suggesting a role for these receptors in the spermatogenic process. The localization of both receptors in the apical portion of epithelial cells and smooth muscle layers of the vas deferens suggests an involvement of these receptors in the contraction and regulation of secretion.
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spelling Expression and function of G-protein-coupled receptorsin the male reproductive tractmuscarinic acetylcholine receptorsα1-adrenoceptorsrelaxin receptorsmale reproductive tractreceptores muscarínicosadrenoceptores α1receptores para relaxinasistema reprodutor masculinoThis review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract. The localization and differential expression of mAChR and α1-adrenoceptor subtypes in specific compartments of the efferent ductules, epididymis, vas deferens, seminal vesicle and prostate of various species indicate a role for these receptors in the modulation of luminal fluid composition and smooth muscle contraction, including effects on male fertility. Furthermore, the activation of mAChRs induces transactivation of the epidermal growth factor receptor (EGFR) and the Sertoli cell proliferation. The relaxin receptors are present in the testis, RXFP1 in elongated spermatids and Sertoli cells from rat, and RXFP2 in Leydig and germ cells from rat and human, suggesting a role for these receptors in the spermatogenic process. The localization of both receptors in the apical portion of epithelial cells and smooth muscle layers of the vas deferens suggests an involvement of these receptors in the contraction and regulation of secretion.Esta revisão enfatiza a expressão e a função dos receptores muscarínicos, adrenoceptores α1 e receptores para relaxina no sistema reprodutor masculino. A expressão dos receptores muscarínicos e adrenoceptores α1 em compartimentos específicos de dúctulos eferentes, epidídimo, ductos deferentes, vesícula seminal e próstata de várias espécies indica o envolvimento destes receptores na modulação da composição do fluido luminal e na contração do músculo liso, incluindo efeitos na fertilidade masculina. Além disso, a ativação dos receptores muscarínicos leva à transativação do receptor para o fator crescimento epidermal e proliferação das células de Sertoli. Os receptores para relaxina estão presentes no testículo, RXFP1 nas espermátides alongadas e células de Sertoli de rato e RXFP2 nas células de Leydig e germinativas de ratos e humano, sugerindo o envolvimento destes receptores no processo espermatogênico. A localização de ambos os receptores na porção apical das células epiteliais e no músculo liso dos ductos deferentes de rato sugere um papel na contração e na regulação da secreção.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FarmacologiaUNIFESP, EPM, Depto. de FarmacologiaSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Academia Brasileira de CiênciasUniversidade Federal de São Paulo (UNIFESP)Avellar, Maria Christina Werneck [UNIFESP]Lazari, Maria de Fatima Magalhaes [UNIFESP]Porto, Catarina Segreti [UNIFESP]2015-06-14T13:41:06Z2015-06-14T13:41:06Z2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion321-344application/pdfhttp://dx.doi.org/10.1590/S0001-37652009000300002Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 321-344, 2009.10.1590/S0001-37652009000300002S0001-37652009000300002.pdf0001-3765S0001-37652009000300002http://repositorio.unifesp.br/handle/11600/5195WOS:000269462300002engAnais da Academia Brasileira de Ciênciasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T14:08:05Zoai:repositorio.unifesp.br/:11600/5195Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T14:08:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Expression and function of G-protein-coupled receptorsin the male reproductive tract
title Expression and function of G-protein-coupled receptorsin the male reproductive tract
spellingShingle Expression and function of G-protein-coupled receptorsin the male reproductive tract
Avellar, Maria Christina Werneck [UNIFESP]
muscarinic acetylcholine receptors
α1-adrenoceptors
relaxin receptors
male reproductive tract
receptores muscarínicos
adrenoceptores α1
receptores para relaxina
sistema reprodutor masculino
title_short Expression and function of G-protein-coupled receptorsin the male reproductive tract
title_full Expression and function of G-protein-coupled receptorsin the male reproductive tract
title_fullStr Expression and function of G-protein-coupled receptorsin the male reproductive tract
title_full_unstemmed Expression and function of G-protein-coupled receptorsin the male reproductive tract
title_sort Expression and function of G-protein-coupled receptorsin the male reproductive tract
author Avellar, Maria Christina Werneck [UNIFESP]
author_facet Avellar, Maria Christina Werneck [UNIFESP]
Lazari, Maria de Fatima Magalhaes [UNIFESP]
Porto, Catarina Segreti [UNIFESP]
author_role author
author2 Lazari, Maria de Fatima Magalhaes [UNIFESP]
Porto, Catarina Segreti [UNIFESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Avellar, Maria Christina Werneck [UNIFESP]
Lazari, Maria de Fatima Magalhaes [UNIFESP]
Porto, Catarina Segreti [UNIFESP]
dc.subject.por.fl_str_mv muscarinic acetylcholine receptors
α1-adrenoceptors
relaxin receptors
male reproductive tract
receptores muscarínicos
adrenoceptores α1
receptores para relaxina
sistema reprodutor masculino
topic muscarinic acetylcholine receptors
α1-adrenoceptors
relaxin receptors
male reproductive tract
receptores muscarínicos
adrenoceptores α1
receptores para relaxina
sistema reprodutor masculino
description This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract. The localization and differential expression of mAChR and α1-adrenoceptor subtypes in specific compartments of the efferent ductules, epididymis, vas deferens, seminal vesicle and prostate of various species indicate a role for these receptors in the modulation of luminal fluid composition and smooth muscle contraction, including effects on male fertility. Furthermore, the activation of mAChRs induces transactivation of the epidermal growth factor receptor (EGFR) and the Sertoli cell proliferation. The relaxin receptors are present in the testis, RXFP1 in elongated spermatids and Sertoli cells from rat, and RXFP2 in Leydig and germ cells from rat and human, suggesting a role for these receptors in the spermatogenic process. The localization of both receptors in the apical portion of epithelial cells and smooth muscle layers of the vas deferens suggests an involvement of these receptors in the contraction and regulation of secretion.
publishDate 2009
dc.date.none.fl_str_mv 2009-09-01
2015-06-14T13:41:06Z
2015-06-14T13:41:06Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0001-37652009000300002
Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 321-344, 2009.
10.1590/S0001-37652009000300002
S0001-37652009000300002.pdf
0001-3765
S0001-37652009000300002
http://repositorio.unifesp.br/handle/11600/5195
WOS:000269462300002
url http://dx.doi.org/10.1590/S0001-37652009000300002
http://repositorio.unifesp.br/handle/11600/5195
identifier_str_mv Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 321-344, 2009.
10.1590/S0001-37652009000300002
S0001-37652009000300002.pdf
0001-3765
S0001-37652009000300002
WOS:000269462300002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais da Academia Brasileira de Ciências
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 321-344
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268272340631552

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