Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/33958 https://dx.doi.org/10.1097/QAI.0b013e31821e9c36 |
Resumo: | Background: There are few studies on HIV subtypes and primary and secondary antiretroviral drug resistance (ADR) in community-recruited samples in Brazil. We analyzed HIV clade diversity and prevalence of mutations associated with ADR in men who have sex with men in all five regions of Brazil.Methods: Using respondent-driven sampling, we recruited 3515 men who have sex with men in nine cities: 299 (9.5%) were HIV-positive; 143 subjects had adequate genotyping and epidemiologic data. Forty-four (30.8%) subjects were antiretroviral therapy-experienced (AE) and 99 (69.2%) antiretroviral therapy-naive (AN). We sequenced the reverse transcriptase and protease regions of the virus and analyzed them for drug resistant mutations using World Health Organization guidelines.Results: the most common subtypes were B (81.8%), C (7.7%), and recombinant forms (6.9%). the overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR was 35.8% (i.e. among the AE). the prevalence of resistance to protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2% (AE). the most common resistance mutation for nucleoside reverse transcriptase inhibitors was 184V (17 cases) and for nonnucleoside reverse transcriptase inhibitors 103N (16 cases).Conclusions: Our data suggest a high level of both primary and secondary ADR in men who have sex with men in Brazil. Additional studies are needed to identify the correlates and causes of antiretroviral therapy resistance to limit the development of resistance among those in care and the transmission of resistant strains in the wider epidemic. |
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Bermudez-Aza, Elkin Hernan [UNIFESP]Kerr, Ligia Regina Franco SansigoloKendall, CarlPinho, Adriana AraujoMello, Maeve Brito deMota, Rosa SalaniCrosland Guimaraes, Mark DrewAlencar, Cecilia Salete [UNIFESP]Brito, Ana Maria deDourado, Ines CostaBatista da Batista, Sonia MariaAbreu, FabianoOliveira, Lisangela Cristina deMoraes, Adao de SouzaBenzaken, Adele SchwartzMerchan-Hamann, EdgarFreitas, Gisele Maria Brandao deMcFarland, WilliAlbuquerque, ElizabethRutherford, George W.Sabino, Ester [UNIFESP]Univ Fed CearaUniversidade Federal de São Paulo (UNIFESP)Tulane UnivUniversidade Federal de Minas Gerais (UFMG)Universidade Federal da Bahia (UFBA)Universidade Federal do Rio de Janeiro (UFRJ)Universidade de Brasília (UnB)Univ Calif San FranciscoUniversidade de São Paulo (USP)2016-01-24T14:17:05Z2016-01-24T14:17:05Z2011-08-15Jaids-Journal of Acquired Immune Deficiency Syndromes. Philadelphia: Lippincott Williams & Wilkins, v. 57, p. S186-S192, 2011.1525-4135https://repositorio.unifesp.br/handle/11600/33958https://dx.doi.org/10.1097/QAI.0b013e31821e9c3610.1097/QAI.0b013e31821e9c36WOS:000293235900010Background: There are few studies on HIV subtypes and primary and secondary antiretroviral drug resistance (ADR) in community-recruited samples in Brazil. We analyzed HIV clade diversity and prevalence of mutations associated with ADR in men who have sex with men in all five regions of Brazil.Methods: Using respondent-driven sampling, we recruited 3515 men who have sex with men in nine cities: 299 (9.5%) were HIV-positive; 143 subjects had adequate genotyping and epidemiologic data. Forty-four (30.8%) subjects were antiretroviral therapy-experienced (AE) and 99 (69.2%) antiretroviral therapy-naive (AN). We sequenced the reverse transcriptase and protease regions of the virus and analyzed them for drug resistant mutations using World Health Organization guidelines.Results: the most common subtypes were B (81.8%), C (7.7%), and recombinant forms (6.9%). the overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR was 35.8% (i.e. among the AE). the prevalence of resistance to protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2% (AE). the most common resistance mutation for nucleoside reverse transcriptase inhibitors was 184V (17 cases) and for nonnucleoside reverse transcriptase inhibitors 103N (16 cases).Conclusions: Our data suggest a high level of both primary and secondary ADR in men who have sex with men in Brazil. Additional studies are needed to identify the correlates and causes of antiretroviral therapy resistance to limit the development of resistance among those in care and the transmission of resistant strains in the wider epidemic.Ministry of Health/Secretariat of Health Surveillance/Department of STD, AIDS and Viral Hepatitis through Brazilian GovernmentMinistry of Health/Secretariat of Health Surveillance/Department of STD, AIDS and Viral Hepatitis through United Nations Office on Drugs and Crime-UNODCDepartment of STD, AIDS and Viral Hepatitis of the Ministry of HealthFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Fed Ceara, Dept Saude Comunitaria, BR-60430971 Fortaleza, Ceara, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilTulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USAUniv Fed Minas Gerais, Belo Horizonte, MG, BrazilUniv Fed Bahia, Inst Saude Colet, BR-41170290 Salvador, BA, BrazilUniv Fed Rio de Janeiro, Rio de Janeiro, BrazilUniv Brasilia, BR-70910900 Brasilia, DF, BrazilUniv Calif San Francisco, San Francisco, CA 94143 USAUniv São Paulo, LIM 03, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilMinistry of Health/Secretariat of Health Surveillance/Department of STD, AIDS and Viral Hepatitis through Brazilian Government: AD/BRA/03/H34Ministry of Health/Secretariat of Health Surveillance/Department of STD, AIDS and Viral Hepatitis through United Nations Office on Drugs and Crime-UNODC: AD/BRA/03/H34Department of STD, AIDS and Viral Hepatitis of the Ministry of Health: CSV 234/07FAPESP: 2004/15856-9CAPES: BEX 3495/06-0Web of ScienceS186-S192engLippincott Williams & WilkinsJaids-Journal of Acquired Immune Deficiency SyndromesHIV-1Men who have sex with menRespondent-driven samplingBrazilAntiretroviral resistanceAntiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/339582023-08-14 19:54:22.005metadata only accessRepositório InstitucionalPUB |
dc.title.en.fl_str_mv |
Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil |
title |
Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil |
spellingShingle |
Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil Bermudez-Aza, Elkin Hernan [UNIFESP] HIV-1 Men who have sex with men Respondent-driven sampling Brazil Antiretroviral resistance |
title_short |
Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil |
title_full |
Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil |
title_fullStr |
Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil |
title_full_unstemmed |
Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil |
title_sort |
Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil |
author |
Bermudez-Aza, Elkin Hernan [UNIFESP] |
author_facet |
Bermudez-Aza, Elkin Hernan [UNIFESP] Kerr, Ligia Regina Franco Sansigolo Kendall, Carl Pinho, Adriana Araujo Mello, Maeve Brito de Mota, Rosa Salani Crosland Guimaraes, Mark Drew Alencar, Cecilia Salete [UNIFESP] Brito, Ana Maria de Dourado, Ines Costa Batista da Batista, Sonia Maria Abreu, Fabiano Oliveira, Lisangela Cristina de Moraes, Adao de Souza Benzaken, Adele Schwartz Merchan-Hamann, Edgar Freitas, Gisele Maria Brandao de McFarland, Willi Albuquerque, Elizabeth Rutherford, George W. Sabino, Ester [UNIFESP] |
author_role |
author |
author2 |
Kerr, Ligia Regina Franco Sansigolo Kendall, Carl Pinho, Adriana Araujo Mello, Maeve Brito de Mota, Rosa Salani Crosland Guimaraes, Mark Drew Alencar, Cecilia Salete [UNIFESP] Brito, Ana Maria de Dourado, Ines Costa Batista da Batista, Sonia Maria Abreu, Fabiano Oliveira, Lisangela Cristina de Moraes, Adao de Souza Benzaken, Adele Schwartz Merchan-Hamann, Edgar Freitas, Gisele Maria Brandao de McFarland, Willi Albuquerque, Elizabeth Rutherford, George W. Sabino, Ester [UNIFESP] |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Univ Fed Ceara Universidade Federal de São Paulo (UNIFESP) Tulane Univ Universidade Federal de Minas Gerais (UFMG) Universidade Federal da Bahia (UFBA) Universidade Federal do Rio de Janeiro (UFRJ) Universidade de Brasília (UnB) Univ Calif San Francisco Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Bermudez-Aza, Elkin Hernan [UNIFESP] Kerr, Ligia Regina Franco Sansigolo Kendall, Carl Pinho, Adriana Araujo Mello, Maeve Brito de Mota, Rosa Salani Crosland Guimaraes, Mark Drew Alencar, Cecilia Salete [UNIFESP] Brito, Ana Maria de Dourado, Ines Costa Batista da Batista, Sonia Maria Abreu, Fabiano Oliveira, Lisangela Cristina de Moraes, Adao de Souza Benzaken, Adele Schwartz Merchan-Hamann, Edgar Freitas, Gisele Maria Brandao de McFarland, Willi Albuquerque, Elizabeth Rutherford, George W. Sabino, Ester [UNIFESP] |
dc.subject.eng.fl_str_mv |
HIV-1 Men who have sex with men Respondent-driven sampling Brazil Antiretroviral resistance |
topic |
HIV-1 Men who have sex with men Respondent-driven sampling Brazil Antiretroviral resistance |
description |
Background: There are few studies on HIV subtypes and primary and secondary antiretroviral drug resistance (ADR) in community-recruited samples in Brazil. We analyzed HIV clade diversity and prevalence of mutations associated with ADR in men who have sex with men in all five regions of Brazil.Methods: Using respondent-driven sampling, we recruited 3515 men who have sex with men in nine cities: 299 (9.5%) were HIV-positive; 143 subjects had adequate genotyping and epidemiologic data. Forty-four (30.8%) subjects were antiretroviral therapy-experienced (AE) and 99 (69.2%) antiretroviral therapy-naive (AN). We sequenced the reverse transcriptase and protease regions of the virus and analyzed them for drug resistant mutations using World Health Organization guidelines.Results: the most common subtypes were B (81.8%), C (7.7%), and recombinant forms (6.9%). the overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR was 35.8% (i.e. among the AE). the prevalence of resistance to protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2% (AE). the most common resistance mutation for nucleoside reverse transcriptase inhibitors was 184V (17 cases) and for nonnucleoside reverse transcriptase inhibitors 103N (16 cases).Conclusions: Our data suggest a high level of both primary and secondary ADR in men who have sex with men in Brazil. Additional studies are needed to identify the correlates and causes of antiretroviral therapy resistance to limit the development of resistance among those in care and the transmission of resistant strains in the wider epidemic. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-08-15 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:17:05Z |
dc.date.available.fl_str_mv |
2016-01-24T14:17:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Jaids-Journal of Acquired Immune Deficiency Syndromes. Philadelphia: Lippincott Williams & Wilkins, v. 57, p. S186-S192, 2011. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/33958 https://dx.doi.org/10.1097/QAI.0b013e31821e9c36 |
dc.identifier.issn.none.fl_str_mv |
1525-4135 |
dc.identifier.doi.none.fl_str_mv |
10.1097/QAI.0b013e31821e9c36 |
dc.identifier.wos.none.fl_str_mv |
WOS:000293235900010 |
identifier_str_mv |
Jaids-Journal of Acquired Immune Deficiency Syndromes. Philadelphia: Lippincott Williams & Wilkins, v. 57, p. S186-S192, 2011. 1525-4135 10.1097/QAI.0b013e31821e9c36 WOS:000293235900010 |
url |
https://repositorio.unifesp.br/handle/11600/33958 https://dx.doi.org/10.1097/QAI.0b013e31821e9c36 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Jaids-Journal of Acquired Immune Deficiency Syndromes |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
S186-S192 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
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1783460233189785600 |