Farmacocinética das estatinas

Detalhes bibliográficos
Autor(a) principal: Fonseca, Francisco Antonio Helfenstein [UNIFESP]
Data de Publicação: 2005
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0066-782X2005002400003
http://repositorio.unifesp.br/handle/11600/2703
Resumo: Statins are lipid lowering agents that promote their effects on plasma lipids through the inhibition of HMG-CoA reductase, a crucial enzyme in the cascade of cholesterol synthesis, leading to reduction of tissue cholesterol pool and consequently, to an upregulation of the LDL receptor expression. There are considerable differences among statins regarding some pharmacokinetic properties, such as the coefficient of hydrophilicity, via liver metabolism (especially regarding P450 cytochrome and isoenzymes), plasma half-life and efficacy of serum lipid changes. They may also differ regarding interactions with other drugs that share the same pathway of metabolism. Recently, many pleiotropic effects have been reported with these drugs, such as anti-inflammatory properties, improvement in endothelial function and benefits on hemostasis.
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spelling Farmacocinética das estatinasPharmacokinetics of statinsStatinspharmacokineticsdrug interactionsEstatinasfarmacocinéticasinteração com drogasStatins are lipid lowering agents that promote their effects on plasma lipids through the inhibition of HMG-CoA reductase, a crucial enzyme in the cascade of cholesterol synthesis, leading to reduction of tissue cholesterol pool and consequently, to an upregulation of the LDL receptor expression. There are considerable differences among statins regarding some pharmacokinetic properties, such as the coefficient of hydrophilicity, via liver metabolism (especially regarding P450 cytochrome and isoenzymes), plasma half-life and efficacy of serum lipid changes. They may also differ regarding interactions with other drugs that share the same pathway of metabolism. Recently, many pleiotropic effects have been reported with these drugs, such as anti-inflammatory properties, improvement in endothelial function and benefits on hemostasis.As estatinas são agentes hipolipemiantes que exercem os seus efeitos através da inibição da HMG-CoA redutase, enzima fundamental na síntese do colesterol, levando a uma redução do colesterol tecidual e um conseqüente aumento na expressão dos receptores de LDL. Existem consideráveis diferenças entre as estatinas, no que tange às propriedades farmacocinéticas, bem como ao coeficiente de hidrofilicidade, via hepática de metabolização (especialmente, do citocromo P450 e isoenzimas), meia-vida plasmática e eficácia na redução lipídica. As estatinas também podem diferir na capacidade de interação com outras drogas que utilizam a mesma via de metabolização. Recentemente, muitos efeitos pleiotrópicos têm sido relatados com estas drogas, bem como propriedades antiinflamatórias, melhora na função endotelial e benefícios na hemostasia.UNIFESP-EPM Setor de Lípides, Aterosclerose e Biologia VascularUNIFESP, EPM, Setor de Lípides, Aterosclerose e Biologia VascularSciELOSociedade Brasileira de Cardiologia - SBCUniversidade Federal de São Paulo (UNIFESP)Fonseca, Francisco Antonio Helfenstein [UNIFESP]2015-06-14T13:31:45Z2015-06-14T13:31:45Z2005-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9-14application/pdfhttp://dx.doi.org/10.1590/S0066-782X2005002400003Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 85, p. 9-14, 2005.10.1590/S0066-782X2005002400003S0066-782X2005002400003.pdf0066-782XS0066-782X2005002400003http://repositorio.unifesp.br/handle/11600/2703porArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T14:18:45Zoai:repositorio.unifesp.br/:11600/2703Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T14:18:45Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Farmacocinética das estatinas
Pharmacokinetics of statins
title Farmacocinética das estatinas
spellingShingle Farmacocinética das estatinas
Fonseca, Francisco Antonio Helfenstein [UNIFESP]
Statins
pharmacokinetics
drug interactions
Estatinas
farmacocinéticas
interação com drogas
title_short Farmacocinética das estatinas
title_full Farmacocinética das estatinas
title_fullStr Farmacocinética das estatinas
title_full_unstemmed Farmacocinética das estatinas
title_sort Farmacocinética das estatinas
author Fonseca, Francisco Antonio Helfenstein [UNIFESP]
author_facet Fonseca, Francisco Antonio Helfenstein [UNIFESP]
author_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Fonseca, Francisco Antonio Helfenstein [UNIFESP]
dc.subject.por.fl_str_mv Statins
pharmacokinetics
drug interactions
Estatinas
farmacocinéticas
interação com drogas
topic Statins
pharmacokinetics
drug interactions
Estatinas
farmacocinéticas
interação com drogas
description Statins are lipid lowering agents that promote their effects on plasma lipids through the inhibition of HMG-CoA reductase, a crucial enzyme in the cascade of cholesterol synthesis, leading to reduction of tissue cholesterol pool and consequently, to an upregulation of the LDL receptor expression. There are considerable differences among statins regarding some pharmacokinetic properties, such as the coefficient of hydrophilicity, via liver metabolism (especially regarding P450 cytochrome and isoenzymes), plasma half-life and efficacy of serum lipid changes. They may also differ regarding interactions with other drugs that share the same pathway of metabolism. Recently, many pleiotropic effects have been reported with these drugs, such as anti-inflammatory properties, improvement in endothelial function and benefits on hemostasis.
publishDate 2005
dc.date.none.fl_str_mv 2005-10-01
2015-06-14T13:31:45Z
2015-06-14T13:31:45Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2005002400003
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 85, p. 9-14, 2005.
10.1590/S0066-782X2005002400003
S0066-782X2005002400003.pdf
0066-782X
S0066-782X2005002400003
http://repositorio.unifesp.br/handle/11600/2703
url http://dx.doi.org/10.1590/S0066-782X2005002400003
http://repositorio.unifesp.br/handle/11600/2703
identifier_str_mv Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 85, p. 9-14, 2005.
10.1590/S0066-782X2005002400003
S0066-782X2005002400003.pdf
0066-782X
S0066-782X2005002400003
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9-14
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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