Prognosis related to staging systems for chronic lymphocytic leukemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2000 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S1516-31802000000400002 http://repositorio.unifesp.br/handle/11600/1002 |
Resumo: | CONTEXT: Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder, characterized by B lymphocytic proliferation. CLL is the most frequent adult leukemia in Western countries, accounting for 25 to 30% of all white leukemic patients. OBJECTIVE: To evaluate clinical and staging characteristics in prognosis of chronic lymphocytic leukemia. DESIGN: Evaluation of clinical-staging data. SETTING: Universidade Federal de São Paulo (UNIFESP) - Escola Paulista de Medicina / Universidade de Alfenas. SAMPLE: 73 patients diagnosed from 1977 to 1994. MAIN MEASUREMENTS: Sex, ethnic origin, age, lymphadenopathy, splenomegaly, hepatomegaly, three or more areas of lymphoid enlargement, hemoglobin (g/dl), lymphocytes/mm³, Platelets/mm³ RESULTS: Mean survival of patients was 76 months, median age was 65 years, ranging from 33 to 87. Forty-four patients (60.3%) were male and 29 (39.7%) female. CONCLUSION: The Binet system determined a better prognosis than Rai. |
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Prognosis related to staging systems for chronic lymphocytic leukemiaChronic Lymphocytic LeukemiaPrognosisClinicalStagingLeucemia linfocítica crônicaPrognósticoClínicaEstadiamentoCONTEXT: Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder, characterized by B lymphocytic proliferation. CLL is the most frequent adult leukemia in Western countries, accounting for 25 to 30% of all white leukemic patients. OBJECTIVE: To evaluate clinical and staging characteristics in prognosis of chronic lymphocytic leukemia. DESIGN: Evaluation of clinical-staging data. SETTING: Universidade Federal de São Paulo (UNIFESP) - Escola Paulista de Medicina / Universidade de Alfenas. SAMPLE: 73 patients diagnosed from 1977 to 1994. MAIN MEASUREMENTS: Sex, ethnic origin, age, lymphadenopathy, splenomegaly, hepatomegaly, three or more areas of lymphoid enlargement, hemoglobin (g/dl), lymphocytes/mm³, Platelets/mm³ RESULTS: Mean survival of patients was 76 months, median age was 65 years, ranging from 33 to 87. Forty-four patients (60.3%) were male and 29 (39.7%) female. CONCLUSION: The Binet system determined a better prognosis than Rai.CONTEXTO: Diversas variáveis clínicas se relacionam ao prognóstico na leucemia linfocítica crônica; no entanto, o estadiamento de Binet determina melhor o prognóstico do que o estadiamento de Rai e Rai modificado. OBJETIVO: Avaliar características clínicas e laboratoriais no prognóstico da leucemia linfocítica crônica. TIPO DE ESTUDO: Estudos de correlação. LOCAL: Universidade Federal de São Paulo (UNIFESP) - Escola Paulista de Medicina / Universidade de Alfenas. PARTICIPANTES: 73 patients diagnosticados entre 1977 e 1994. VARIÁVEIS ESTUDADAS: Sexo, origem étnica, idade, linfadenomegalia, esplenomegalia, hepatomegalia, três ou mais áreas com aumento linfóide, hemoglobina, linfocitos, plaquetas. RESULTADOS: A sobrevida média dos pacientes foi 76 meses, idade média de 65 anos, variando de 33 a 87 anos. Quarenta e quatro pacientes (60,3%) eram do sexo masculino e 29 (39,7%) do sexo feminino. A análise univariada mostrou que o nível de hemoglobina (P = 0,001), número de plaquetas (P = 0,03), linfocitose periférica (P = 0,03), número de áreas linfóides acometidas (P = 0,01), assim como os estadiamentos de Rai (P = 0,02), Rai modificado (0,007) e Binet (P = 0,003) relacionaram-se significantemente com a sobrevida. A análise multivariada, pela regressão de Cox, demonstrou que o sistema de Binet determina melhor o prognóstico do que os estadiamentos de Rai e Rai modificado. CONCLUSÃO: O estadiamento de Binet é melhor que o estadiamento de Rai e Rai modificado na determinação do prognóstico.Universidade de Alfenas Division of HematologyUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Division of HematologyUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Division of EpidemiologyUNIFESP, EPM, Division of HematologyUNIFESP, EPM, Division of EpidemiologySciELOAssociação Paulista de Medicina - APMUniversidade de Alfenas Division of HematologyUniversidade Federal de São Paulo (UNIFESP)Faria, José Roberto deOliveira, José Salvador Rodrigues de [UNIFESP]Faria, Rosa Malena Delbone deSilva, Maria Regina RegisGoihman, Samuel [UNIFESP]Yamamoto, Mihoko [UNIFESP]Kerbauy, José [UNIFESP]2015-06-14T13:25:05Z2015-06-14T13:25:05Z2000-07-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion83-88application/pdfhttp://dx.doi.org/10.1590/S1516-31802000000400002São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 118, n. 4, p. 83-88, 2000.10.1590/S1516-31802000000400002S1516-31802000000400002.pdf1516-3180S1516-31802000000400002http://repositorio.unifesp.br/handle/11600/1002engSão Paulo Medical Journalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T00:44:26Zoai:repositorio.unifesp.br/:11600/1002Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T00:44:26Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Prognosis related to staging systems for chronic lymphocytic leukemia |
| title |
Prognosis related to staging systems for chronic lymphocytic leukemia |
| spellingShingle |
Prognosis related to staging systems for chronic lymphocytic leukemia Faria, José Roberto de Chronic Lymphocytic Leukemia Prognosis Clinical Staging Leucemia linfocítica crônica Prognóstico Clínica Estadiamento |
| title_short |
Prognosis related to staging systems for chronic lymphocytic leukemia |
| title_full |
Prognosis related to staging systems for chronic lymphocytic leukemia |
| title_fullStr |
Prognosis related to staging systems for chronic lymphocytic leukemia |
| title_full_unstemmed |
Prognosis related to staging systems for chronic lymphocytic leukemia |
| title_sort |
Prognosis related to staging systems for chronic lymphocytic leukemia |
| author |
Faria, José Roberto de |
| author_facet |
Faria, José Roberto de Oliveira, José Salvador Rodrigues de [UNIFESP] Faria, Rosa Malena Delbone de Silva, Maria Regina Regis Goihman, Samuel [UNIFESP] Yamamoto, Mihoko [UNIFESP] Kerbauy, José [UNIFESP] |
| author_role |
author |
| author2 |
Oliveira, José Salvador Rodrigues de [UNIFESP] Faria, Rosa Malena Delbone de Silva, Maria Regina Regis Goihman, Samuel [UNIFESP] Yamamoto, Mihoko [UNIFESP] Kerbauy, José [UNIFESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade de Alfenas Division of Hematology Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Faria, José Roberto de Oliveira, José Salvador Rodrigues de [UNIFESP] Faria, Rosa Malena Delbone de Silva, Maria Regina Regis Goihman, Samuel [UNIFESP] Yamamoto, Mihoko [UNIFESP] Kerbauy, José [UNIFESP] |
| dc.subject.por.fl_str_mv |
Chronic Lymphocytic Leukemia Prognosis Clinical Staging Leucemia linfocítica crônica Prognóstico Clínica Estadiamento |
| topic |
Chronic Lymphocytic Leukemia Prognosis Clinical Staging Leucemia linfocítica crônica Prognóstico Clínica Estadiamento |
| description |
CONTEXT: Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder, characterized by B lymphocytic proliferation. CLL is the most frequent adult leukemia in Western countries, accounting for 25 to 30% of all white leukemic patients. OBJECTIVE: To evaluate clinical and staging characteristics in prognosis of chronic lymphocytic leukemia. DESIGN: Evaluation of clinical-staging data. SETTING: Universidade Federal de São Paulo (UNIFESP) - Escola Paulista de Medicina / Universidade de Alfenas. SAMPLE: 73 patients diagnosed from 1977 to 1994. MAIN MEASUREMENTS: Sex, ethnic origin, age, lymphadenopathy, splenomegaly, hepatomegaly, three or more areas of lymphoid enlargement, hemoglobin (g/dl), lymphocytes/mm³, Platelets/mm³ RESULTS: Mean survival of patients was 76 months, median age was 65 years, ranging from 33 to 87. Forty-four patients (60.3%) were male and 29 (39.7%) female. CONCLUSION: The Binet system determined a better prognosis than Rai. |
| publishDate |
2000 |
| dc.date.none.fl_str_mv |
2000-07-06 2015-06-14T13:25:05Z 2015-06-14T13:25:05Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-31802000000400002 São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 118, n. 4, p. 83-88, 2000. 10.1590/S1516-31802000000400002 S1516-31802000000400002.pdf 1516-3180 S1516-31802000000400002 http://repositorio.unifesp.br/handle/11600/1002 |
| url |
http://dx.doi.org/10.1590/S1516-31802000000400002 http://repositorio.unifesp.br/handle/11600/1002 |
| identifier_str_mv |
São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 118, n. 4, p. 83-88, 2000. 10.1590/S1516-31802000000400002 S1516-31802000000400002.pdf 1516-3180 S1516-31802000000400002 |
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eng |
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eng |
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São Paulo Medical Journal |
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83-88 application/pdf |
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Associação Paulista de Medicina - APM |
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Associação Paulista de Medicina - APM |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268320632799232 |