Role of thyroid hormone in protecting against gentamicin-induced nephrotoxicity

• Autor(a) principal: Gomes, Guiomar Nascimento
• Data de Publicação: 1996
• Outros Autores: Silva, Vera Lidia Costa [UNIFESP], Cavanal, Maria de Fátima [UNIFESP], Gil, Frida Zaladek [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/25572; http://dx.doi.org/10.1016/S0011-393X(96)80035-X

This study investigates the protective effect of thyroid hormone (T-4) in an in vivo model of gentamicin nephrotoxicity, Rats were divided into a control group and groups treated with either T-4 alone (C + T-4), gentamicin 40 mg/kg/d alone (G(40)), or T-4 for 14 days with G(40) in the last 10 days (T-4 + G(40)). the glomerular variables assessed showed similar results in groups G(40) and T-4 + G(40), (glomerular filtration rate, 5.31 +/- 0.27 mL . min(-1) . kg(-1) with G(40) and 5.40 +/- 0.23 mL . min(-1) . kg(-1) with T-4 + G(40); renal plasma flow, 14.87 +/- 0.97 mL . min(-1) . kg(-1) with G(40) and 14.71 +/- 0.97 mL . min(-1) . kg(-1) with T-4 + G(40). Some values of tubular functions that were impaired in the group that received gentamicin alone were similar to the values in the group treated with T-4 + G(40). Urine HCO3- concentration was 1.98 +/- 0.44 mEq/mL/kg with G(40), 0.85 +/- 0.26 mEq/mL/kg with T-4 + G(40), 0.879 +/- 0.117 mEq/mL/kg with C + T-4, and 0.882 +/- 0.06 mEq/mL/kg in the control group; net acid excretion was 4.01 +/- 0.11 mu Eq . min(-1) . kg(-1) with G(40), 5.24 +/- 0.34 mu Eq min(-1) . kg(-1) with T-4 + G(40), 5.47 +/- 0.24 mu Eq . min(-1) . kg(-1) with C + T-4, and 5.86 +/- 0.29 mu Eq . min(-1) . kg(-1) in the control group; and sodium excretion was 10.32 +/- 1.09 mu Eq . min(-1) . kg(-1) with G(40), 4.72 +/- 0.43 mu Eq . min(-1) . kg(-1) with T-4 + G(40), 4.84 +/- 0.20 mu Eq . min(-1) . kg(-1) for C + T-4, and 7.12 +/- 0.86 mu Eq . min(-1) . kg(-1) in the control group. These results suggest that T-4 protects the tubular function against epithelial injury but does not prevent the glomerular changes induced by gentamicin.