Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/1913 http://dx.doi.org/10.1590/S0100-879X2003001200010 |
Resumo: | Administration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age. To determine in detail the electrophysiological patterns of the epileptogenic activity in these animals, 46 Wistar rats, 7-17 days old, were subjected to SE induced by pilocarpine and electro-oscillograms from the cortex, hippocampus, amygdala, thalamus and hypothalamus, as well as head, rostrum and vibrissa, eye, ear and forelimb movements, were recorded 120 days later. Six control animals of the same age range did not show any signs of epilepsy. In all the rats subjected to SE, iterative spike-wave complexes (8.1 ± 0.5 Hz in frequency, 18.9 ± 9.1 s in duration) were recorded from the frontal cortex during absence fits. However, similar spike-wave discharges were always found also in the hippocampus and, less frequently, in the amygdala and in thalamic nuclei. Repetitive or single spikes were also detected in these same central structures. Clonic movements and single jerks were recorded from all the rats, either concomitantly with or independently of the spike-wave complexes and spikes. We conclude that rats made epileptic with pilocarpine develop absence seizures also occurring during paradoxical sleep, showing the characteristic spike-wave bursts in neocortical areas and also in the hippocampus. This is in contrast to the well-accepted statement that one of the main characteristics of absence-like fits in the rat is that spike-wave discharges are never recorded from the hippocampal fields. |
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Ferreira, B.l.c. [UNIFESP]Valle, A.c.Cavalheiro, Esper Abrão [UNIFESP]Timo-iaria, C.Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:30:11Z2015-06-14T13:30:11Z2003-12-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 12, p. 1685-1694, 2003.0100-879Xhttp://repositorio.unifesp.br/handle/11600/1913http://dx.doi.org/10.1590/S0100-879X2003001200010S0100-879X2003001200010.pdfS0100-879X200300120001010.1590/S0100-879X2003001200010WOS:000187175000010Administration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age. To determine in detail the electrophysiological patterns of the epileptogenic activity in these animals, 46 Wistar rats, 7-17 days old, were subjected to SE induced by pilocarpine and electro-oscillograms from the cortex, hippocampus, amygdala, thalamus and hypothalamus, as well as head, rostrum and vibrissa, eye, ear and forelimb movements, were recorded 120 days later. Six control animals of the same age range did not show any signs of epilepsy. In all the rats subjected to SE, iterative spike-wave complexes (8.1 ± 0.5 Hz in frequency, 18.9 ± 9.1 s in duration) were recorded from the frontal cortex during absence fits. However, similar spike-wave discharges were always found also in the hippocampus and, less frequently, in the amygdala and in thalamic nuclei. Repetitive or single spikes were also detected in these same central structures. Clonic movements and single jerks were recorded from all the rats, either concomitantly with or independently of the spike-wave complexes and spikes. We conclude that rats made epileptic with pilocarpine develop absence seizures also occurring during paradoxical sleep, showing the characteristic spike-wave bursts in neocortical areas and also in the hippocampus. This is in contrast to the well-accepted statement that one of the main characteristics of absence-like fits in the rat is that spike-wave discharges are never recorded from the hippocampal fields.Universidade de São Paulo Faculdade de Medicina Laboratório de Neurocirurgia FuncionalUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Laboratório de Neurologia ExperimentalUNIFESP, EPM, Laboratório de Neurologia ExperimentalSciELO1685-1694engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchEpilepsyAbsence seizuresSpike-waveStatus epilepticusPilocarpineAbsence-like seizures in adult rats following pilocarpine-induced status epilepticus early in lifeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2003001200010.pdfapplication/pdf1453172${dspace.ui.url}/bitstream/11600/1913/1/S0100-879X2003001200010.pdf195011bcd0647b783f6d984b1a7b4e1aMD51open accessTEXTS0100-879X2003001200010.pdf.txtS0100-879X2003001200010.pdf.txtExtracted texttext/plain39076${dspace.ui.url}/bitstream/11600/1913/2/S0100-879X2003001200010.pdf.txt2730ec46d5bce635b2bbd8b2c892133bMD52open access11600/19132021-10-04 21:20:47.442open accessoai:repositorio.unifesp.br:11600/1913Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:22:10.364124Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life |
title |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life |
spellingShingle |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life Ferreira, B.l.c. [UNIFESP] Epilepsy Absence seizures Spike-wave Status epilepticus Pilocarpine |
title_short |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life |
title_full |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life |
title_fullStr |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life |
title_full_unstemmed |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life |
title_sort |
Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life |
author |
Ferreira, B.l.c. [UNIFESP] |
author_facet |
Ferreira, B.l.c. [UNIFESP] Valle, A.c. Cavalheiro, Esper Abrão [UNIFESP] Timo-iaria, C. |
author_role |
author |
author2 |
Valle, A.c. Cavalheiro, Esper Abrão [UNIFESP] Timo-iaria, C. |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Ferreira, B.l.c. [UNIFESP] Valle, A.c. Cavalheiro, Esper Abrão [UNIFESP] Timo-iaria, C. |
dc.subject.eng.fl_str_mv |
Epilepsy Absence seizures Spike-wave Status epilepticus Pilocarpine |
topic |
Epilepsy Absence seizures Spike-wave Status epilepticus Pilocarpine |
description |
Administration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age. To determine in detail the electrophysiological patterns of the epileptogenic activity in these animals, 46 Wistar rats, 7-17 days old, were subjected to SE induced by pilocarpine and electro-oscillograms from the cortex, hippocampus, amygdala, thalamus and hypothalamus, as well as head, rostrum and vibrissa, eye, ear and forelimb movements, were recorded 120 days later. Six control animals of the same age range did not show any signs of epilepsy. In all the rats subjected to SE, iterative spike-wave complexes (8.1 ± 0.5 Hz in frequency, 18.9 ± 9.1 s in duration) were recorded from the frontal cortex during absence fits. However, similar spike-wave discharges were always found also in the hippocampus and, less frequently, in the amygdala and in thalamic nuclei. Repetitive or single spikes were also detected in these same central structures. Clonic movements and single jerks were recorded from all the rats, either concomitantly with or independently of the spike-wave complexes and spikes. We conclude that rats made epileptic with pilocarpine develop absence seizures also occurring during paradoxical sleep, showing the characteristic spike-wave bursts in neocortical areas and also in the hippocampus. This is in contrast to the well-accepted statement that one of the main characteristics of absence-like fits in the rat is that spike-wave discharges are never recorded from the hippocampal fields. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003-12-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:30:11Z |
dc.date.available.fl_str_mv |
2015-06-14T13:30:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 12, p. 1685-1694, 2003. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/1913 http://dx.doi.org/10.1590/S0100-879X2003001200010 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2003001200010.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2003001200010 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2003001200010 |
dc.identifier.wos.none.fl_str_mv |
WOS:000187175000010 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 12, p. 1685-1694, 2003. 0100-879X S0100-879X2003001200010.pdf S0100-879X2003001200010 10.1590/S0100-879X2003001200010 WOS:000187175000010 |
url |
http://repositorio.unifesp.br/handle/11600/1913 http://dx.doi.org/10.1590/S0100-879X2003001200010 |
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eng |
language |
eng |
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Brazilian Journal of Medical and Biological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
1685-1694 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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