Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/36867 https://dx.doi.org/10.3389/fnbeh.2013.00134 |
Resumo: | Traumatic stress can lead to long-term emotional alterations, which may result in Posttraumatic Stress Disorder (PTSD). Fear reactions triggered by conditioned cues and exacerbated emotional arousal in face of non-conditioned stimuli are among the most prominent features of PTSD. We hypothesized that long-term emotional alterations seen in PTSD may depend on the strength of context-trauma association. Here, we investigated the contribution of previous contextual exploration to the long-term emotional outcomes of an intense foot shock in rats. We exposed male Wistar rats to a highly stressful event (foot shock, 2 mA, 1 sec) allowing them to explore or not the chamber prior to trauma. We, then, evaluated the long-term effects on emotionality. Fear was assessed by the time spent in freezing behavior either upon re-exposure to trauma context or upon exposure to an unknown environment made potentially more aversive by presentation of an acoustic stimulus. Behaviors on the elevated-plus-maze and acoustic startle response were also assessed. the possibility to explore the environment immediately before the aversive event led to differential long-term emotional effects, including a heightened freezing response to re-exposure to context, blunted exploratory behavior, fear sensitization and exacerbation of the acoustic startle response, in contrast to the minor outcomes of the foot shock with no prior context exploration. the data showed the strong contribution of contextual learning to long-term behavioral effects of traumatic stress. We argue that contextual representation contributes to the robust long-term behavioral alterations seen in this model of traumatic stress. |
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Girardi, Carlos Eduardo Neves [UNIFESP]Tiba, Paula Ayako [UNIFESP]Llobet, Gisela B. [UNIFESP]Levin, Raquel [UNIFESP]Abilio, Vanessa Costhek [UNIFESP]Suchecki, Deborah [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade Federal do ABC (UFABC)2016-01-24T14:34:34Z2016-01-24T14:34:34Z2013-10-02Frontiers in Behavioral Neuroscience. Lausanne: Frontiers Research Foundation, v. 7, 8 p., 2013.1662-5153https://repositorio.unifesp.br/handle/11600/36867https://dx.doi.org/10.3389/fnbeh.2013.00134WOS000325067700001.pdf10.3389/fnbeh.2013.00134WOS:000325067700001Traumatic stress can lead to long-term emotional alterations, which may result in Posttraumatic Stress Disorder (PTSD). Fear reactions triggered by conditioned cues and exacerbated emotional arousal in face of non-conditioned stimuli are among the most prominent features of PTSD. We hypothesized that long-term emotional alterations seen in PTSD may depend on the strength of context-trauma association. Here, we investigated the contribution of previous contextual exploration to the long-term emotional outcomes of an intense foot shock in rats. We exposed male Wistar rats to a highly stressful event (foot shock, 2 mA, 1 sec) allowing them to explore or not the chamber prior to trauma. We, then, evaluated the long-term effects on emotionality. Fear was assessed by the time spent in freezing behavior either upon re-exposure to trauma context or upon exposure to an unknown environment made potentially more aversive by presentation of an acoustic stimulus. Behaviors on the elevated-plus-maze and acoustic startle response were also assessed. the possibility to explore the environment immediately before the aversive event led to differential long-term emotional effects, including a heightened freezing response to re-exposure to context, blunted exploratory behavior, fear sensitization and exacerbation of the acoustic startle response, in contrast to the minor outcomes of the foot shock with no prior context exploration. the data showed the strong contribution of contextual learning to long-term behavioral effects of traumatic stress. We argue that contextual representation contributes to the robust long-term behavioral alterations seen in this model of traumatic stress.AFIP (Associacao Fundo de Incentivo a Pesquisa)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, BrazilUniv Fed ABC, Ctr Matemat Comp & Cognicao, SantoAndre, BrazilUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin, BR-04023062 São Paulo, BrazilWeb of Science8engFrontiers Research FoundationFrontiers in Behavioral NeuroscienceContext fear conditioningcontextual configurationPTSDEmotional behaviorPsychiatric disorderAnimal modelContextual exploration previous to an aversive event predicts long-term emotional consequences of severe stressinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000325067700001.pdfapplication/pdf621530${dspace.ui.url}/bitstream/11600/36867/1/WOS000325067700001.pdf91b2013df84303873b40ca19919745a0MD51open accessTEXTWOS000325067700001.pdf.txtWOS000325067700001.pdf.txtExtracted texttext/plain46348${dspace.ui.url}/bitstream/11600/36867/2/WOS000325067700001.pdf.txt96a566530dede8160ce2c8e55e1ba321MD52open access11600/368672023-03-27 16:27:08.34open accessoai:repositorio.unifesp.br:11600/36867Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-03-27T19:27:08Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress |
title |
Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress |
spellingShingle |
Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress Girardi, Carlos Eduardo Neves [UNIFESP] Context fear conditioning contextual configuration PTSD Emotional behavior Psychiatric disorder Animal model |
title_short |
Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress |
title_full |
Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress |
title_fullStr |
Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress |
title_full_unstemmed |
Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress |
title_sort |
Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress |
author |
Girardi, Carlos Eduardo Neves [UNIFESP] |
author_facet |
Girardi, Carlos Eduardo Neves [UNIFESP] Tiba, Paula Ayako [UNIFESP] Llobet, Gisela B. [UNIFESP] Levin, Raquel [UNIFESP] Abilio, Vanessa Costhek [UNIFESP] Suchecki, Deborah [UNIFESP] |
author_role |
author |
author2 |
Tiba, Paula Ayako [UNIFESP] Llobet, Gisela B. [UNIFESP] Levin, Raquel [UNIFESP] Abilio, Vanessa Costhek [UNIFESP] Suchecki, Deborah [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal do ABC (UFABC) |
dc.contributor.author.fl_str_mv |
Girardi, Carlos Eduardo Neves [UNIFESP] Tiba, Paula Ayako [UNIFESP] Llobet, Gisela B. [UNIFESP] Levin, Raquel [UNIFESP] Abilio, Vanessa Costhek [UNIFESP] Suchecki, Deborah [UNIFESP] |
dc.subject.eng.fl_str_mv |
Context fear conditioning contextual configuration PTSD Emotional behavior Psychiatric disorder Animal model |
topic |
Context fear conditioning contextual configuration PTSD Emotional behavior Psychiatric disorder Animal model |
description |
Traumatic stress can lead to long-term emotional alterations, which may result in Posttraumatic Stress Disorder (PTSD). Fear reactions triggered by conditioned cues and exacerbated emotional arousal in face of non-conditioned stimuli are among the most prominent features of PTSD. We hypothesized that long-term emotional alterations seen in PTSD may depend on the strength of context-trauma association. Here, we investigated the contribution of previous contextual exploration to the long-term emotional outcomes of an intense foot shock in rats. We exposed male Wistar rats to a highly stressful event (foot shock, 2 mA, 1 sec) allowing them to explore or not the chamber prior to trauma. We, then, evaluated the long-term effects on emotionality. Fear was assessed by the time spent in freezing behavior either upon re-exposure to trauma context or upon exposure to an unknown environment made potentially more aversive by presentation of an acoustic stimulus. Behaviors on the elevated-plus-maze and acoustic startle response were also assessed. the possibility to explore the environment immediately before the aversive event led to differential long-term emotional effects, including a heightened freezing response to re-exposure to context, blunted exploratory behavior, fear sensitization and exacerbation of the acoustic startle response, in contrast to the minor outcomes of the foot shock with no prior context exploration. the data showed the strong contribution of contextual learning to long-term behavioral effects of traumatic stress. We argue that contextual representation contributes to the robust long-term behavioral alterations seen in this model of traumatic stress. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-10-02 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:34Z |
dc.date.available.fl_str_mv |
2016-01-24T14:34:34Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Frontiers in Behavioral Neuroscience. Lausanne: Frontiers Research Foundation, v. 7, 8 p., 2013. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/36867 https://dx.doi.org/10.3389/fnbeh.2013.00134 |
dc.identifier.issn.none.fl_str_mv |
1662-5153 |
dc.identifier.file.none.fl_str_mv |
WOS000325067700001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.3389/fnbeh.2013.00134 |
dc.identifier.wos.none.fl_str_mv |
WOS:000325067700001 |
identifier_str_mv |
Frontiers in Behavioral Neuroscience. Lausanne: Frontiers Research Foundation, v. 7, 8 p., 2013. 1662-5153 WOS000325067700001.pdf 10.3389/fnbeh.2013.00134 WOS:000325067700001 |
url |
https://repositorio.unifesp.br/handle/11600/36867 https://dx.doi.org/10.3389/fnbeh.2013.00134 |
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eng |
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Frontiers in Behavioral Neuroscience |
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8 |
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Frontiers Research Foundation |
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Frontiers Research Foundation |
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