Effects of heart failure on cerebral blood flow in copd: rest and exercise
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/49183 https://doi.org/10.1016/j.resp.2015.10.005 |
Resumo: | Cerebral blood flow (CBF) and oxygenation (COx) are generally well-preserved in COPD. It is unknown whether prevalent cardiovascular co-morbidities, such as heart failure, may impair CBF and COx responses to exertion. Eighteen males with moderate-to-severe COPD (8 with and 10 without overlapping heart failure) underwent a progressive exercise test with pre-frontal CBF and COx measurements (indocyanine green and near-infrared spectroscopy). Mean arterial pressure and cardiac output were lower from rest to exercise in overlap. Only COPD patients demonstrated an increase in arterialized PCO2 towards the end of progressive exercise. CBF index was consistently higher and increased further by similar to 40% during exercise in COPD whereas a similar to 10% reduction was observed in overlap. COx was lower in overlap despite preserved arterial oxygenation. In conclusion, heart failure introduces pronounced negative effects on CBF and COx in COPD which may be associated with clinically relevant outcomes, including dyspnea, exercise intolerance, cerebrovascular disease and cognitive impairment. (C) 2015 Elsevier B.V. All rights reserved. |
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Oliveira, Mayron Faria [UNIFESP]Alencar, Maria Clara [UNIFESP]Arbex, Flavio [UNIFESP]Souza, Aline [UNIFESP]Sperandio, Priscila [UNIFESP]Medina, Luiz [UNIFESP]Medeiros, Wladimir Musetti [UNIFESP]Hirai, Daniel Müller [UNIFESP]O'Donnell, Denis E.Neder, Jose Alberto [UNIFESP]2019-01-21T10:29:21Z2019-01-21T10:29:21Z2016Respiratory Physiology & Neurobiology. Amsterdam, v. 221, p. 41-48, 2016.1569-9048http://repositorio.unifesp.br/handle/11600/49183https://doi.org/10.1016/j.resp.2015.10.00510.1016/j.resp.2015.10.005WOS:000368208500006Cerebral blood flow (CBF) and oxygenation (COx) are generally well-preserved in COPD. It is unknown whether prevalent cardiovascular co-morbidities, such as heart failure, may impair CBF and COx responses to exertion. Eighteen males with moderate-to-severe COPD (8 with and 10 without overlapping heart failure) underwent a progressive exercise test with pre-frontal CBF and COx measurements (indocyanine green and near-infrared spectroscopy). Mean arterial pressure and cardiac output were lower from rest to exercise in overlap. Only COPD patients demonstrated an increase in arterialized PCO2 towards the end of progressive exercise. CBF index was consistently higher and increased further by similar to 40% during exercise in COPD whereas a similar to 10% reduction was observed in overlap. COx was lower in overlap despite preserved arterial oxygenation. In conclusion, heart failure introduces pronounced negative effects on CBF and COx in COPD which may be associated with clinically relevant outcomes, including dyspnea, exercise intolerance, cerebrovascular disease and cognitive impairment. (C) 2015 Elsevier B.V. All rights reserved.Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respirology, Federal University of Sao Paulo, Sao Paulo, BrazilRespiratory Investigation Unit & Laboratory of Clinical Exercise Physiology, Queen’s University & Kingston General Hospital, Kingston, ON, CanadaPulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respirology, Federal University of Sao Paulo, Sao Paulo, BrazilWeb of Science41-48engElsevier Science BvRespiratory Physiology & NeurobiologyCerebral OxygenationChronic Obstructive Pulmonary DiseaseComorbidityNear-Infrared SpectroscopyObstructive Pulmonary-DiseaseNear-Infrared SpectroscopyCerebrovascular ResponsesNoninvasive MeasurementEjection FractionIndocyanine GreenCardiac-OutputOxygenationMechanismsCortexEffects of heart failure on cerebral blood flow in copd: rest and exerciseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/491832022-02-10 21:18:18.352metadata only accessoai:repositorio.unifesp.br:11600/49183Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:22:00.706544Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of heart failure on cerebral blood flow in copd: rest and exercise |
title |
Effects of heart failure on cerebral blood flow in copd: rest and exercise |
spellingShingle |
Effects of heart failure on cerebral blood flow in copd: rest and exercise Oliveira, Mayron Faria [UNIFESP] Cerebral Oxygenation Chronic Obstructive Pulmonary Disease Comorbidity Near-Infrared SpectroscopyObstructive Pulmonary-Disease Near-Infrared Spectroscopy Cerebrovascular Responses Noninvasive Measurement Ejection Fraction Indocyanine Green Cardiac-Output Oxygenation Mechanisms Cortex |
title_short |
Effects of heart failure on cerebral blood flow in copd: rest and exercise |
title_full |
Effects of heart failure on cerebral blood flow in copd: rest and exercise |
title_fullStr |
Effects of heart failure on cerebral blood flow in copd: rest and exercise |
title_full_unstemmed |
Effects of heart failure on cerebral blood flow in copd: rest and exercise |
title_sort |
Effects of heart failure on cerebral blood flow in copd: rest and exercise |
author |
Oliveira, Mayron Faria [UNIFESP] |
author_facet |
Oliveira, Mayron Faria [UNIFESP] Alencar, Maria Clara [UNIFESP] Arbex, Flavio [UNIFESP] Souza, Aline [UNIFESP] Sperandio, Priscila [UNIFESP] Medina, Luiz [UNIFESP] Medeiros, Wladimir Musetti [UNIFESP] Hirai, Daniel Müller [UNIFESP] O'Donnell, Denis E. Neder, Jose Alberto [UNIFESP] |
author_role |
author |
author2 |
Alencar, Maria Clara [UNIFESP] Arbex, Flavio [UNIFESP] Souza, Aline [UNIFESP] Sperandio, Priscila [UNIFESP] Medina, Luiz [UNIFESP] Medeiros, Wladimir Musetti [UNIFESP] Hirai, Daniel Müller [UNIFESP] O'Donnell, Denis E. Neder, Jose Alberto [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Mayron Faria [UNIFESP] Alencar, Maria Clara [UNIFESP] Arbex, Flavio [UNIFESP] Souza, Aline [UNIFESP] Sperandio, Priscila [UNIFESP] Medina, Luiz [UNIFESP] Medeiros, Wladimir Musetti [UNIFESP] Hirai, Daniel Müller [UNIFESP] O'Donnell, Denis E. Neder, Jose Alberto [UNIFESP] |
dc.subject.eng.fl_str_mv |
Cerebral Oxygenation Chronic Obstructive Pulmonary Disease Comorbidity Near-Infrared SpectroscopyObstructive Pulmonary-Disease Near-Infrared Spectroscopy Cerebrovascular Responses Noninvasive Measurement Ejection Fraction Indocyanine Green Cardiac-Output Oxygenation Mechanisms Cortex |
topic |
Cerebral Oxygenation Chronic Obstructive Pulmonary Disease Comorbidity Near-Infrared SpectroscopyObstructive Pulmonary-Disease Near-Infrared Spectroscopy Cerebrovascular Responses Noninvasive Measurement Ejection Fraction Indocyanine Green Cardiac-Output Oxygenation Mechanisms Cortex |
description |
Cerebral blood flow (CBF) and oxygenation (COx) are generally well-preserved in COPD. It is unknown whether prevalent cardiovascular co-morbidities, such as heart failure, may impair CBF and COx responses to exertion. Eighteen males with moderate-to-severe COPD (8 with and 10 without overlapping heart failure) underwent a progressive exercise test with pre-frontal CBF and COx measurements (indocyanine green and near-infrared spectroscopy). Mean arterial pressure and cardiac output were lower from rest to exercise in overlap. Only COPD patients demonstrated an increase in arterialized PCO2 towards the end of progressive exercise. CBF index was consistently higher and increased further by similar to 40% during exercise in COPD whereas a similar to 10% reduction was observed in overlap. COx was lower in overlap despite preserved arterial oxygenation. In conclusion, heart failure introduces pronounced negative effects on CBF and COx in COPD which may be associated with clinically relevant outcomes, including dyspnea, exercise intolerance, cerebrovascular disease and cognitive impairment. (C) 2015 Elsevier B.V. All rights reserved. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2019-01-21T10:29:21Z |
dc.date.available.fl_str_mv |
2019-01-21T10:29:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Respiratory Physiology & Neurobiology. Amsterdam, v. 221, p. 41-48, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/49183 https://doi.org/10.1016/j.resp.2015.10.005 |
dc.identifier.issn.none.fl_str_mv |
1569-9048 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.resp.2015.10.005 |
dc.identifier.wos.none.fl_str_mv |
WOS:000368208500006 |
identifier_str_mv |
Respiratory Physiology & Neurobiology. Amsterdam, v. 221, p. 41-48, 2016. 1569-9048 10.1016/j.resp.2015.10.005 WOS:000368208500006 |
url |
http://repositorio.unifesp.br/handle/11600/49183 https://doi.org/10.1016/j.resp.2015.10.005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Respiratory Physiology & Neurobiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
41-48 |
dc.publisher.none.fl_str_mv |
Elsevier Science Bv |
publisher.none.fl_str_mv |
Elsevier Science Bv |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
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1783460282077544448 |