Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/775 http://dx.doi.org/10.1590/S0100-879X1999000500005 |
Resumo: | The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates. |
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Nader, Helena Bonciani [UNIFESP]Chavante, Suely Ferreira [UNIFESP]Santos, Elizeu Antunes dosOliveira, Fernanda WanderleyPaiva, José Fernandes de [UNIFESP]Jerônimo, Selma Maria BezerraMedeiros, Guilherme Fulgencio de [UNIFESP]Abreu, Luiz Roberto Diz de [UNIFESP]Leite, Edda LisboaSousa-Filho, João Felipe deCastro, Rodrigo de Aquino [UNIFESP]Toma, Leny [UNIFESP]Tersariol, Ivarne Luis dos Santos [UNIFESP]Porcionatto, Marimélia Aparecida [UNIFESP]Dietrich, Carl Peter [UNIFESP]Universidade Federal de São Paulo (UNIFESP)A02Universidade Federal do Rio Grande do NorteUniversidade de Mogi das Cruzes2015-06-14T13:24:52Z2015-06-14T13:24:52Z1999-05-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999.0100-879Xhttp://repositorio.unifesp.br/handle/11600/775http://dx.doi.org/10.1590/S0100-879X1999000500005S0100-879X1999000500005.pdfS0100-879X199900050000510.1590/S0100-879X1999000500005WOS:000080489600005The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.Universidade Federal de São Paulo (UNIFESP)A02Universidade Federal do Rio Grande do NorteUniversidade de Mogi das CruzesUNIFESP, EPMSciELO529-538engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Researchheparin - occurrence and functionheparan sulfate - occurrence and functionheparin - invertebratesheparan sulfate - invertebratesheparin and heparan sulfate - structureHeparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X1999000500005.pdfapplication/pdf366281${dspace.ui.url}/bitstream/11600/775/1/S0100-879X1999000500005.pdf5581996096e5689b4c24c73cada028dfMD51open accessTEXTS0100-879X1999000500005.pdf.txtS0100-879X1999000500005.pdf.txtExtracted texttext/plain25812${dspace.ui.url}/bitstream/11600/775/2/S0100-879X1999000500005.pdf.txtbc73bffd9dfddc634cc68e2941b48490MD52open access11600/7752022-07-08 10:58:22.995open accessoai:repositorio.unifesp.br:11600/775Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-07-08T13:58:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
spellingShingle |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? Nader, Helena Bonciani [UNIFESP] heparin - occurrence and function heparan sulfate - occurrence and function heparin - invertebrates heparan sulfate - invertebrates heparin and heparan sulfate - structure |
title_short |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title_full |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title_fullStr |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title_full_unstemmed |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
title_sort |
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
author |
Nader, Helena Bonciani [UNIFESP] |
author_facet |
Nader, Helena Bonciani [UNIFESP] Chavante, Suely Ferreira [UNIFESP] Santos, Elizeu Antunes dos Oliveira, Fernanda Wanderley Paiva, José Fernandes de [UNIFESP] Jerônimo, Selma Maria Bezerra Medeiros, Guilherme Fulgencio de [UNIFESP] Abreu, Luiz Roberto Diz de [UNIFESP] Leite, Edda Lisboa Sousa-Filho, João Felipe de Castro, Rodrigo de Aquino [UNIFESP] Toma, Leny [UNIFESP] Tersariol, Ivarne Luis dos Santos [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Dietrich, Carl Peter [UNIFESP] |
author_role |
author |
author2 |
Chavante, Suely Ferreira [UNIFESP] Santos, Elizeu Antunes dos Oliveira, Fernanda Wanderley Paiva, José Fernandes de [UNIFESP] Jerônimo, Selma Maria Bezerra Medeiros, Guilherme Fulgencio de [UNIFESP] Abreu, Luiz Roberto Diz de [UNIFESP] Leite, Edda Lisboa Sousa-Filho, João Felipe de Castro, Rodrigo de Aquino [UNIFESP] Toma, Leny [UNIFESP] Tersariol, Ivarne Luis dos Santos [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Dietrich, Carl Peter [UNIFESP] |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) A02 Universidade Federal do Rio Grande do Norte Universidade de Mogi das Cruzes |
dc.contributor.author.fl_str_mv |
Nader, Helena Bonciani [UNIFESP] Chavante, Suely Ferreira [UNIFESP] Santos, Elizeu Antunes dos Oliveira, Fernanda Wanderley Paiva, José Fernandes de [UNIFESP] Jerônimo, Selma Maria Bezerra Medeiros, Guilherme Fulgencio de [UNIFESP] Abreu, Luiz Roberto Diz de [UNIFESP] Leite, Edda Lisboa Sousa-Filho, João Felipe de Castro, Rodrigo de Aquino [UNIFESP] Toma, Leny [UNIFESP] Tersariol, Ivarne Luis dos Santos [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Dietrich, Carl Peter [UNIFESP] |
dc.subject.eng.fl_str_mv |
heparin - occurrence and function heparan sulfate - occurrence and function heparin - invertebrates heparan sulfate - invertebrates heparin and heparan sulfate - structure |
topic |
heparin - occurrence and function heparan sulfate - occurrence and function heparin - invertebrates heparan sulfate - invertebrates heparin and heparan sulfate - structure |
description |
The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates. |
publishDate |
1999 |
dc.date.issued.fl_str_mv |
1999-05-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:24:52Z |
dc.date.available.fl_str_mv |
2015-06-14T13:24:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/775 http://dx.doi.org/10.1590/S0100-879X1999000500005 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X1999000500005.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X1999000500005 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X1999000500005 |
dc.identifier.wos.none.fl_str_mv |
WOS:000080489600005 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999. 0100-879X S0100-879X1999000500005.pdf S0100-879X1999000500005 10.1590/S0100-879X1999000500005 WOS:000080489600005 |
url |
http://repositorio.unifesp.br/handle/11600/775 http://dx.doi.org/10.1590/S0100-879X1999000500005 |
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eng |
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eng |
dc.relation.ispartof.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
529-538 |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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