Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1139/Y10-062 http://repositorio.unifesp.br/handle/11600/32651 |
Resumo: | After myocardial infarction, the hemodynamics under basal conditions might appear to be unaltered, which makes it difficult to identify cardiac dysfunction by the usual approaches. Thus, we tested the response to sudden afterload stress in infarcted rats with apparently normal ejection function. Control (CT) and infarcted (MI) Wistar rats with various MI sizes were submitted to echocardiography 30 days after coronary occlusion, followed by assessment of hemodynamics under basal conditions and during a pharmacologically induced sudden pressure overload (phenylephrine 15-25 mg/kg, i.v.). Coronary occlusion resulted in cardiac remodeling proportional to MI size, although several functional parameters such as systolic pressure (SP), stroke volume (SV), and stroke work (SW) of all MI rats were similar to those of CT rats. However, the afterload stress that was produced led to a relative preservation of SV and an increase of SW in CT rats; MI rats exhibited a significant reduction in SV and SW generation, although global cardiac function was normal under basal conditions, as indicated by regular echocardiography and hemodynamics assessment. Thus, we propose the use of sudden pharmacologically induced afterload stress as a practical and efficient procedure for identifying impaired performance of the heart in anesthetized rats, providing an additional physiological variable to be evaluated in experimental therapeutic studies. |
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Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failurepressure overloadcardiac functionhemodynamic changesventricular pressureafterload mismatchphenylephrineratAfter myocardial infarction, the hemodynamics under basal conditions might appear to be unaltered, which makes it difficult to identify cardiac dysfunction by the usual approaches. Thus, we tested the response to sudden afterload stress in infarcted rats with apparently normal ejection function. Control (CT) and infarcted (MI) Wistar rats with various MI sizes were submitted to echocardiography 30 days after coronary occlusion, followed by assessment of hemodynamics under basal conditions and during a pharmacologically induced sudden pressure overload (phenylephrine 15-25 mg/kg, i.v.). Coronary occlusion resulted in cardiac remodeling proportional to MI size, although several functional parameters such as systolic pressure (SP), stroke volume (SV), and stroke work (SW) of all MI rats were similar to those of CT rats. However, the afterload stress that was produced led to a relative preservation of SV and an increase of SW in CT rats; MI rats exhibited a significant reduction in SV and SW generation, although global cardiac function was normal under basal conditions, as indicated by regular echocardiography and hemodynamics assessment. Thus, we propose the use of sudden pharmacologically induced afterload stress as a practical and efficient procedure for identifying impaired performance of the heart in anesthetized rats, providing an additional physiological variable to be evaluated in experimental therapeutic studies.Universidade Federal de São Paulo, Div Cardiol, São Paulo, BrazilUniversidade Federal de São Paulo, Cardioresp Physiol Div, São Paulo, BrazilUniversidade Federal de São Paulo, Div Cardiol, São Paulo, BrazilUniversidade Federal de São Paulo, Cardioresp Physiol Div, São Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Natl Research Council Canada-n R C Research PressUniversidade Federal de São Paulo (UNIFESP)Santos, Leonardo dos [UNIFESP]Antonio, Ednei L. [UNIFESP]Souza, Ana F. M. [UNIFESP]Tucci, Paulo J. F. [UNIFESP]2016-01-24T13:59:49Z2016-01-24T13:59:49Z2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion724-732http://dx.doi.org/10.1139/Y10-062Canadian Journal of Physiology and Pharmacology. Ottawa: Natl Research Council Canada-n R C Research Press, v. 88, n. 7, p. 724-732, 2010.10.1139/Y10-0620008-4212http://repositorio.unifesp.br/handle/11600/32651WOS:000281209700004engCanadian Journal of Physiology and Pharmacologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-11-04T14:22:11Zoai:repositorio.unifesp.br/:11600/32651Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-11-04T14:22:11Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure |
title |
Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure |
spellingShingle |
Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure Santos, Leonardo dos [UNIFESP] pressure overload cardiac function hemodynamic changes ventricular pressure afterload mismatch phenylephrine rat |
title_short |
Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure |
title_full |
Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure |
title_fullStr |
Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure |
title_full_unstemmed |
Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure |
title_sort |
Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure |
author |
Santos, Leonardo dos [UNIFESP] |
author_facet |
Santos, Leonardo dos [UNIFESP] Antonio, Ednei L. [UNIFESP] Souza, Ana F. M. [UNIFESP] Tucci, Paulo J. F. [UNIFESP] |
author_role |
author |
author2 |
Antonio, Ednei L. [UNIFESP] Souza, Ana F. M. [UNIFESP] Tucci, Paulo J. F. [UNIFESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Santos, Leonardo dos [UNIFESP] Antonio, Ednei L. [UNIFESP] Souza, Ana F. M. [UNIFESP] Tucci, Paulo J. F. [UNIFESP] |
dc.subject.por.fl_str_mv |
pressure overload cardiac function hemodynamic changes ventricular pressure afterload mismatch phenylephrine rat |
topic |
pressure overload cardiac function hemodynamic changes ventricular pressure afterload mismatch phenylephrine rat |
description |
After myocardial infarction, the hemodynamics under basal conditions might appear to be unaltered, which makes it difficult to identify cardiac dysfunction by the usual approaches. Thus, we tested the response to sudden afterload stress in infarcted rats with apparently normal ejection function. Control (CT) and infarcted (MI) Wistar rats with various MI sizes were submitted to echocardiography 30 days after coronary occlusion, followed by assessment of hemodynamics under basal conditions and during a pharmacologically induced sudden pressure overload (phenylephrine 15-25 mg/kg, i.v.). Coronary occlusion resulted in cardiac remodeling proportional to MI size, although several functional parameters such as systolic pressure (SP), stroke volume (SV), and stroke work (SW) of all MI rats were similar to those of CT rats. However, the afterload stress that was produced led to a relative preservation of SV and an increase of SW in CT rats; MI rats exhibited a significant reduction in SV and SW generation, although global cardiac function was normal under basal conditions, as indicated by regular echocardiography and hemodynamics assessment. Thus, we propose the use of sudden pharmacologically induced afterload stress as a practical and efficient procedure for identifying impaired performance of the heart in anesthetized rats, providing an additional physiological variable to be evaluated in experimental therapeutic studies. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-07-01 2016-01-24T13:59:49Z 2016-01-24T13:59:49Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1139/Y10-062 Canadian Journal of Physiology and Pharmacology. Ottawa: Natl Research Council Canada-n R C Research Press, v. 88, n. 7, p. 724-732, 2010. 10.1139/Y10-062 0008-4212 http://repositorio.unifesp.br/handle/11600/32651 WOS:000281209700004 |
url |
http://dx.doi.org/10.1139/Y10-062 http://repositorio.unifesp.br/handle/11600/32651 |
identifier_str_mv |
Canadian Journal of Physiology and Pharmacology. Ottawa: Natl Research Council Canada-n R C Research Press, v. 88, n. 7, p. 724-732, 2010. 10.1139/Y10-062 0008-4212 WOS:000281209700004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Canadian Journal of Physiology and Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
724-732 |
dc.publisher.none.fl_str_mv |
Natl Research Council Canada-n R C Research Press |
publisher.none.fl_str_mv |
Natl Research Council Canada-n R C Research Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268318091051008 |