Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36232 http://dx.doi.org/10.1016/j.rmed.2013.01.015 |
Resumo: | Background: Although the association between latitude and asthma prevalence has been studied to a certain extent, its influence on the magnitude of the association of risk/protective factors with recurrent wheeze in infants has never been reported.Methods: the adjusted odd ratios (aOR) of various risk/protective factors for recurrent wheeze from 31 920 infants from 19 centres of the Estudio Internacional de Sibilacias en Lactantes (EISL) in very different parts of the world were used to build a meta-regression using the strength of the aOR of each factor as dependent variable and centre latitude as explanatory variable. the meta-regression was further adjusted for continent.Results: There was a positive significant correlation between latitude and the magnitude of the aOR between recurrent wheeze and having cold(s) during the first three months of life (p = 0.004); attending a nursery school (p = 0.011); and having additional siblings (p = 0.003). Furthermore, there was a negative correlation for having been breastfed for at Least three months (p = 0.044). Heterogeneity (as measured by I-2) of the magnitude of aORs between centres was quite high except for breast feeding: 73.1% for colds; 66.9% for nursery school; 52.6% for additional siblings; and 18.1% for breast feeding. Latitude explained a considerable amount of that heterogeneity: 63.8% for colds; 52.8% for nursery school; 86.6% for additional siblings; and 100% for breast feeding, probably as a consequence of its low heterogeneity.Conclusion: the magnitude in which some risk/protective factors are associated to recurrent wheeze during the first year of life varies significantly with latitude. (C) 2013 Elsevier B.V. All rights reserved. |
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Garcia-Marcos, LuisMallol, JavierSolé, Dirceu [UNIFESP]Brand, Paul L. P.Sanchez-Bahillo, MariaSanchez-Solis, ManuelEISL Study GrpUniv MurciaUniv Santiago Chile USACHUniversidade Federal de São Paulo (UNIFESP)Isala KlinUniv Groningen2016-01-24T14:31:37Z2016-01-24T14:31:37Z2013-05-01Respiratory Medicine. London: W B Saunders Co Ltd, v. 107, n. 5, p. 665-672, 2013.0954-6111http://repositorio.unifesp.br/handle/11600/36232http://dx.doi.org/10.1016/j.rmed.2013.01.015WOS000318327400004.pdf10.1016/j.rmed.2013.01.015WOS:000318327400004Background: Although the association between latitude and asthma prevalence has been studied to a certain extent, its influence on the magnitude of the association of risk/protective factors with recurrent wheeze in infants has never been reported.Methods: the adjusted odd ratios (aOR) of various risk/protective factors for recurrent wheeze from 31 920 infants from 19 centres of the Estudio Internacional de Sibilacias en Lactantes (EISL) in very different parts of the world were used to build a meta-regression using the strength of the aOR of each factor as dependent variable and centre latitude as explanatory variable. the meta-regression was further adjusted for continent.Results: There was a positive significant correlation between latitude and the magnitude of the aOR between recurrent wheeze and having cold(s) during the first three months of life (p = 0.004); attending a nursery school (p = 0.011); and having additional siblings (p = 0.003). Furthermore, there was a negative correlation for having been breastfed for at Least three months (p = 0.044). Heterogeneity (as measured by I-2) of the magnitude of aORs between centres was quite high except for breast feeding: 73.1% for colds; 66.9% for nursery school; 52.6% for additional siblings; and 18.1% for breast feeding. Latitude explained a considerable amount of that heterogeneity: 63.8% for colds; 52.8% for nursery school; 86.6% for additional siblings; and 100% for breast feeding, probably as a consequence of its low heterogeneity.Conclusion: the magnitude in which some risk/protective factors are associated to recurrent wheeze during the first year of life varies significantly with latitude. (C) 2013 Elsevier B.V. All rights reserved.Spanish Fondo de Investigacion SanitariaSecretaria de Estado para la Cooperacion InternacionalUniv Murcia, Pediat Resp & Allergy Unit, Virgen de la Arrixaca Univ Childrens Hosp, Murcia 30120, SpainUniv Santiago Chile USACH, Dept Pediat Resp Med, Hosp El Pino, San Bernardo, Santiago Metrop, ChileFed Univ São Paulo UNIFESP, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, BR-04039032 São Paulo, BrazilIsala Klin, Princess Amalia Childrens Clin, Zwolle, NetherlandsUniv Groningen, Univ Med Ctr Groningen, UMCG Postgrad Sch Med, NL-8000 GK Zwolle, NetherlandsUniv Murcia, Dept Pediat, Murcia 30120, SpainFed Univ São Paulo UNIFESP, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, BR-04039032 São Paulo, BrazilSpanish Fondo de Investigacion Sanitaria: PI050480Secretaria de Estado para la Cooperacion Internacional: A/3069/05Secretaria de Estado para la Cooperacion Internacional: A/5189/06Web of Science665-672engW B Saunders Co LtdRespiratory MedicineWheezingEpidemiologyLatitudeBreast feedingInfantEISLLatitude modifies the effect size of factors related to recurrent wheeze in the first year of lifeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000318327400004.pdfapplication/pdf384108${dspace.ui.url}/bitstream/11600/36232/1/WOS000318327400004.pdf3eaa0ee48a1d6b7e9c2483e55b9fbdf6MD51open accessTEXTWOS000318327400004.pdf.txtWOS000318327400004.pdf.txtExtracted texttext/plain35666${dspace.ui.url}/bitstream/11600/36232/21/WOS000318327400004.pdf.txt266297422ac50f50b9dc66f369ad7d4bMD521open accessTHUMBNAILWOS000318327400004.pdf.jpgWOS000318327400004.pdf.jpgIM Thumbnailimage/jpeg7289${dspace.ui.url}/bitstream/11600/36232/23/WOS000318327400004.pdf.jpg54083a183e10bf6812eaca6bab51d62dMD523open access11600/362322023-06-05 19:43:42.405open accessoai:repositorio.unifesp.br:11600/36232Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:43:42Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life |
title |
Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life |
spellingShingle |
Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life Garcia-Marcos, Luis Wheezing Epidemiology Latitude Breast feeding Infant EISL |
title_short |
Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life |
title_full |
Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life |
title_fullStr |
Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life |
title_full_unstemmed |
Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life |
title_sort |
Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life |
author |
Garcia-Marcos, Luis |
author_facet |
Garcia-Marcos, Luis Mallol, Javier Solé, Dirceu [UNIFESP] Brand, Paul L. P. Sanchez-Bahillo, Maria Sanchez-Solis, Manuel EISL Study Grp |
author_role |
author |
author2 |
Mallol, Javier Solé, Dirceu [UNIFESP] Brand, Paul L. P. Sanchez-Bahillo, Maria Sanchez-Solis, Manuel EISL Study Grp |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Univ Murcia Univ Santiago Chile USACH Universidade Federal de São Paulo (UNIFESP) Isala Klin Univ Groningen |
dc.contributor.author.fl_str_mv |
Garcia-Marcos, Luis Mallol, Javier Solé, Dirceu [UNIFESP] Brand, Paul L. P. Sanchez-Bahillo, Maria Sanchez-Solis, Manuel EISL Study Grp |
dc.subject.eng.fl_str_mv |
Wheezing Epidemiology Latitude Breast feeding Infant EISL |
topic |
Wheezing Epidemiology Latitude Breast feeding Infant EISL |
description |
Background: Although the association between latitude and asthma prevalence has been studied to a certain extent, its influence on the magnitude of the association of risk/protective factors with recurrent wheeze in infants has never been reported.Methods: the adjusted odd ratios (aOR) of various risk/protective factors for recurrent wheeze from 31 920 infants from 19 centres of the Estudio Internacional de Sibilacias en Lactantes (EISL) in very different parts of the world were used to build a meta-regression using the strength of the aOR of each factor as dependent variable and centre latitude as explanatory variable. the meta-regression was further adjusted for continent.Results: There was a positive significant correlation between latitude and the magnitude of the aOR between recurrent wheeze and having cold(s) during the first three months of life (p = 0.004); attending a nursery school (p = 0.011); and having additional siblings (p = 0.003). Furthermore, there was a negative correlation for having been breastfed for at Least three months (p = 0.044). Heterogeneity (as measured by I-2) of the magnitude of aORs between centres was quite high except for breast feeding: 73.1% for colds; 66.9% for nursery school; 52.6% for additional siblings; and 18.1% for breast feeding. Latitude explained a considerable amount of that heterogeneity: 63.8% for colds; 52.8% for nursery school; 86.6% for additional siblings; and 100% for breast feeding, probably as a consequence of its low heterogeneity.Conclusion: the magnitude in which some risk/protective factors are associated to recurrent wheeze during the first year of life varies significantly with latitude. (C) 2013 Elsevier B.V. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-05-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:37Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:37Z |
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info:eu-repo/semantics/publishedVersion |
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format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Respiratory Medicine. London: W B Saunders Co Ltd, v. 107, n. 5, p. 665-672, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36232 http://dx.doi.org/10.1016/j.rmed.2013.01.015 |
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0954-6111 |
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WOS000318327400004.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.rmed.2013.01.015 |
dc.identifier.wos.none.fl_str_mv |
WOS:000318327400004 |
identifier_str_mv |
Respiratory Medicine. London: W B Saunders Co Ltd, v. 107, n. 5, p. 665-672, 2013. 0954-6111 WOS000318327400004.pdf 10.1016/j.rmed.2013.01.015 WOS:000318327400004 |
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http://repositorio.unifesp.br/handle/11600/36232 http://dx.doi.org/10.1016/j.rmed.2013.01.015 |
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eng |
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Respiratory Medicine |
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665-672 |
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W B Saunders Co Ltd |
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W B Saunders Co Ltd |
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