Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/30455 https://dx.doi.org/10.1042/CS20070284 |
Resumo: | There have been only a few reports on the sympathoadrenal and renin-angiotensin systems in children of small gestational age. the purpose of the present study was to investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66 children (35 boys and 31 girls) in two groups: those born at term with an appropriate birthweight [AGA (appropriate-for-gestational age) group, n = 31] and those born at term but with a small birthweight for gestational age [SGA (small-for-gestational age) group, n = 35]. Concentrations of angiotensin, catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls (P = 0.036). in addition, angiotensin 11 and ACE activity were higher in SGA boys (P = 0.024 and P = 0.050 respectively). There was a significant association of the circulating levels of both angiotensin 11 and ACE activity with BP levels in our study population. Although the underlying mechanisms that link restricted fetal growth with later cardiovascular events are not fully understood, the findings in the present study support the link between low birthweight and overactivity of both sympathoadrenal and renin-angiotensin systems into later childhood. |
id |
UFSP_dab2c31c0591988d822350024eb00169 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/30455 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Franco, Maria do Carmo Pinho [UNIFESP]Casarini, Dulce Elena [UNIFESP]Carneiro-Ramos, Marcella S.Sawaya, Ana Lydia [UNIFESP]Barreto-Chaves, Maria Luiza M.Sesso, Ricardo de Castro Cintra [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T13:49:35Z2016-01-24T13:49:35Z2008-03-01Clinical Science. London: Portland Press Ltd, v. 114, n. 5-6, p. 375-380, 2008.0143-5221https://repositorio.unifesp.br/handle/11600/30455https://dx.doi.org/10.1042/CS2007028410.1042/CS20070284WOS:000253849000003There have been only a few reports on the sympathoadrenal and renin-angiotensin systems in children of small gestational age. the purpose of the present study was to investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66 children (35 boys and 31 girls) in two groups: those born at term with an appropriate birthweight [AGA (appropriate-for-gestational age) group, n = 31] and those born at term but with a small birthweight for gestational age [SGA (small-for-gestational age) group, n = 35]. Concentrations of angiotensin, catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls (P = 0.036). in addition, angiotensin 11 and ACE activity were higher in SGA boys (P = 0.024 and P = 0.050 respectively). There was a significant association of the circulating levels of both angiotensin 11 and ACE activity with BP levels in our study population. Although the underlying mechanisms that link restricted fetal growth with later cardiovascular events are not fully understood, the findings in the present study support the link between low birthweight and overactivity of both sympathoadrenal and renin-angiotensin systems into later childhood.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Sch Med, Div Nephrol, BR-04023900 São Paulo, BrazilUniv São Paulo, Inst Biomed Sci, BR-05508900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Sch Med, Div Nephrol, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, BrazilFAPESP: 04/10342-7FAPESP: 04/01672-3Web of Science375-380engPortland Press LtdClinical ScienceAngiotensin IIAngiotensin-converting enzyme (ACE) activityBirthweightBlood pressureNoradrenalineSmall-for-gestational ageCirculating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/304552022-02-08 17:50:49.568metadata only accessoai:repositorio.unifesp.br:11600/30455Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:21:52.710158Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight? |
title |
Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight? |
spellingShingle |
Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight? Franco, Maria do Carmo Pinho [UNIFESP] Angiotensin II Angiotensin-converting enzyme (ACE) activity Birthweight Blood pressure Noradrenaline Small-for-gestational age |
title_short |
Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight? |
title_full |
Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight? |
title_fullStr |
Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight? |
title_full_unstemmed |
Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight? |
title_sort |
Circulating renin-angiotensin system and catecholamines in childhood: is there a role for birthweight? |
author |
Franco, Maria do Carmo Pinho [UNIFESP] |
author_facet |
Franco, Maria do Carmo Pinho [UNIFESP] Casarini, Dulce Elena [UNIFESP] Carneiro-Ramos, Marcella S. Sawaya, Ana Lydia [UNIFESP] Barreto-Chaves, Maria Luiza M. Sesso, Ricardo de Castro Cintra [UNIFESP] |
author_role |
author |
author2 |
Casarini, Dulce Elena [UNIFESP] Carneiro-Ramos, Marcella S. Sawaya, Ana Lydia [UNIFESP] Barreto-Chaves, Maria Luiza M. Sesso, Ricardo de Castro Cintra [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Franco, Maria do Carmo Pinho [UNIFESP] Casarini, Dulce Elena [UNIFESP] Carneiro-Ramos, Marcella S. Sawaya, Ana Lydia [UNIFESP] Barreto-Chaves, Maria Luiza M. Sesso, Ricardo de Castro Cintra [UNIFESP] |
dc.subject.eng.fl_str_mv |
Angiotensin II Angiotensin-converting enzyme (ACE) activity Birthweight Blood pressure Noradrenaline Small-for-gestational age |
topic |
Angiotensin II Angiotensin-converting enzyme (ACE) activity Birthweight Blood pressure Noradrenaline Small-for-gestational age |
description |
There have been only a few reports on the sympathoadrenal and renin-angiotensin systems in children of small gestational age. the purpose of the present study was to investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66 children (35 boys and 31 girls) in two groups: those born at term with an appropriate birthweight [AGA (appropriate-for-gestational age) group, n = 31] and those born at term but with a small birthweight for gestational age [SGA (small-for-gestational age) group, n = 35]. Concentrations of angiotensin, catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls (P = 0.036). in addition, angiotensin 11 and ACE activity were higher in SGA boys (P = 0.024 and P = 0.050 respectively). There was a significant association of the circulating levels of both angiotensin 11 and ACE activity with BP levels in our study population. Although the underlying mechanisms that link restricted fetal growth with later cardiovascular events are not fully understood, the findings in the present study support the link between low birthweight and overactivity of both sympathoadrenal and renin-angiotensin systems into later childhood. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:49:35Z |
dc.date.available.fl_str_mv |
2016-01-24T13:49:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinical Science. London: Portland Press Ltd, v. 114, n. 5-6, p. 375-380, 2008. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/30455 https://dx.doi.org/10.1042/CS20070284 |
dc.identifier.issn.none.fl_str_mv |
0143-5221 |
dc.identifier.doi.none.fl_str_mv |
10.1042/CS20070284 |
dc.identifier.wos.none.fl_str_mv |
WOS:000253849000003 |
identifier_str_mv |
Clinical Science. London: Portland Press Ltd, v. 114, n. 5-6, p. 375-380, 2008. 0143-5221 10.1042/CS20070284 WOS:000253849000003 |
url |
https://repositorio.unifesp.br/handle/11600/30455 https://dx.doi.org/10.1042/CS20070284 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Clinical Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
375-380 |
dc.publisher.none.fl_str_mv |
Portland Press Ltd |
publisher.none.fl_str_mv |
Portland Press Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460281530187776 |