Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample

Detalhes bibliográficos
Autor(a) principal: Mazzotti, Diego Robles [UNIFESP]
Data de Publicação: 2011
Outros Autores: Guindalini, Camila [UNIFESP], Pellegrino, Renata [UNIFESP], Barrueco, Karina Fonseca [UNIFESP], Santos-Silva, Rogerio [UNIFESP], Bittencourt, Lia Rita Azeredo [UNIFESP], Tufik, Sergio [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://doi.org/10.1093/sleep/34.3.399
https://repositorio.unifesp.br/handle/11600/45611
Resumo: Study Objectives: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.Design: Genetic association study.Setting: NAPatients or Participants: 958 participants who underwent polysomnography and genotyping.Interventions: NAMeasurements and Results: Individuals carrying the A allele who consumed caffeine in the day prior to polysomnography demonstrated higher sleep efficiency and REM sleep percentage, after adjustment for potential confounders. No effect was observed in the absence of caffeine.Conclusions: Our data support the role of the ADA G22A polymorphism in sleep, and demonstrate for the first time that caffeine may act as a modulator of its functional effects.
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spelling Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population SampleSleepAdenosine deaminaseCaffeine intakePolymorphismSleep efficiencyStudy Objectives: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.Design: Genetic association study.Setting: NAPatients or Participants: 958 participants who underwent polysomnography and genotyping.Interventions: NAMeasurements and Results: Individuals carrying the A allele who consumed caffeine in the day prior to polysomnography demonstrated higher sleep efficiency and REM sleep percentage, after adjustment for potential confounders. No effect was observed in the absence of caffeine.Conclusions: Our data support the role of the ADA G22A polymorphism in sleep, and demonstrate for the first time that caffeine may act as a modulator of its functional effects.Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psiquiatria, Lab Neurociencias Clin LiNC, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psicobiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psiquiatria, Lab Neurociencias Clin LiNC, Sao Paulo, BrazilWeb of ScienceAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 98/14303-3Amer Acad Sleep MedicineUniversidade Federal de São Paulo (UNIFESP)Mazzotti, Diego Robles [UNIFESP]Guindalini, Camila [UNIFESP]Pellegrino, Renata [UNIFESP]Barrueco, Karina Fonseca [UNIFESP]Santos-Silva, Rogerio [UNIFESP]Bittencourt, Lia Rita Azeredo [UNIFESP]Tufik, Sergio [UNIFESP]2018-06-18T12:12:00Z2018-06-18T12:12:00Z2011-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion399-402https://doi.org/10.1093/sleep/34.3.399Sleep. Westchester: Amer Acad Sleep Medicine, v. 34, n. 3, p. 399-402, 2011.0161-8105https://repositorio.unifesp.br/handle/11600/45611WOS:000287917600021engSleepinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-09T09:32:31Zoai:repositorio.unifesp.br/:11600/45611Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-09T09:32:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
title Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
spellingShingle Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
Mazzotti, Diego Robles [UNIFESP]
Sleep
Adenosine deaminase
Caffeine intake
Polymorphism
Sleep efficiency
title_short Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
title_full Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
title_fullStr Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
title_full_unstemmed Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
title_sort Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
author Mazzotti, Diego Robles [UNIFESP]
author_facet Mazzotti, Diego Robles [UNIFESP]
Guindalini, Camila [UNIFESP]
Pellegrino, Renata [UNIFESP]
Barrueco, Karina Fonseca [UNIFESP]
Santos-Silva, Rogerio [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Tufik, Sergio [UNIFESP]
author_role author
author2 Guindalini, Camila [UNIFESP]
Pellegrino, Renata [UNIFESP]
Barrueco, Karina Fonseca [UNIFESP]
Santos-Silva, Rogerio [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Tufik, Sergio [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Mazzotti, Diego Robles [UNIFESP]
Guindalini, Camila [UNIFESP]
Pellegrino, Renata [UNIFESP]
Barrueco, Karina Fonseca [UNIFESP]
Santos-Silva, Rogerio [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Tufik, Sergio [UNIFESP]
dc.subject.por.fl_str_mv Sleep
Adenosine deaminase
Caffeine intake
Polymorphism
Sleep efficiency
topic Sleep
Adenosine deaminase
Caffeine intake
Polymorphism
Sleep efficiency
description Study Objectives: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.Design: Genetic association study.Setting: NAPatients or Participants: 958 participants who underwent polysomnography and genotyping.Interventions: NAMeasurements and Results: Individuals carrying the A allele who consumed caffeine in the day prior to polysomnography demonstrated higher sleep efficiency and REM sleep percentage, after adjustment for potential confounders. No effect was observed in the absence of caffeine.Conclusions: Our data support the role of the ADA G22A polymorphism in sleep, and demonstrate for the first time that caffeine may act as a modulator of its functional effects.
publishDate 2011
dc.date.none.fl_str_mv 2011-03-01
2018-06-18T12:12:00Z
2018-06-18T12:12:00Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1093/sleep/34.3.399
Sleep. Westchester: Amer Acad Sleep Medicine, v. 34, n. 3, p. 399-402, 2011.
0161-8105
https://repositorio.unifesp.br/handle/11600/45611
WOS:000287917600021
url https://doi.org/10.1093/sleep/34.3.399
https://repositorio.unifesp.br/handle/11600/45611
identifier_str_mv Sleep. Westchester: Amer Acad Sleep Medicine, v. 34, n. 3, p. 399-402, 2011.
0161-8105
WOS:000287917600021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sleep
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 399-402
dc.publisher.none.fl_str_mv Amer Acad Sleep Medicine
publisher.none.fl_str_mv Amer Acad Sleep Medicine
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268405306359808

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