Low urinary 6-sulphatoxymelatonin concentrations in acute migraine

• Autor(a) principal: Masruha, Marcelo Rodrigues [UNIFESP]
• Data de Publicação: 2008
• Outros Autores: Vieira, Domingos Sávio de Souza [UNIFESP], Minett, Thaís Soares Cianciarullo [UNIFESP], Cipolla-Neto, Jose, Zukerman, Eliova [UNIFESP], Vilanova, Luiz Celso Pereira [UNIFESP], Peres, Mario Fernando Prieto [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1007/s10194-008-0047-5; http://repositorio.unifesp.br/handle/11600/30807
• topic: Circadian rhythm; Pathophysiology; Melatonin; Migraine; Headache

Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. the objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated-146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 +/- 7.3 vs. 49.4 +/- 19.0; t(143) = -15.1; 95% CI = -40.0 to -30.8; P<0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 +/- 19.0 vs. 42.5 +/- 27.9; t(140) = 1.7; 95% CI = -1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.