Genital prevalence of HPV types and co-infection in men
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37177 http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.01.10 |
Resumo: | Introduction: HPV infection is a highly prevalent sexually transmitted disease and there is evidence of the relationship of HPV infection and the development of genital warts, penile intraepitelial neoplasia, invasive penile carcinoma and cervical cancer. However, there is sparse data regarding the prevalence of HPV types and co-infection of different HPV types among men.Objectives: To assess the prevalence of HPV subtypes infections and rates of co-infection among men.Materials and Methods: 366 men were evaluated from March to October 2010. Men were referred to our institution for HPV diagnostic evaluation based on the following criteria: 1. presence of a genital wart; 2. presence of an atypical genital lesion; 3. absence of symptoms and a partner with a HPV diagnosis; 4. absence of symptoms and a desire to undergo a full STD diagnostic evaluation. Genital samples were collected from the urethra, penile shaft, scrotum and anus with Digene (R) collection and preservation kit and submitted to HPV genotype microarray detection (Papillocheck (R)). All men were tested for the low-risk HPV types 6-11-40-42-43-44 and for the high-risk HPV types 16-18-31-33-35-39-45-51-52-53-56-58-59-66-68-70-73-82.Results: of the 366 men, 11 were tested inconclusive and were excluded from the analysis. 256 men (72.1% of the men from the cohort referred to our institution) tested positive with genotype micro-array detection and 99 tested negative. the most prevalent HPV-subtypes in the studied population were 6, 42, 51 and 16. Co-infection was found in 153 men. of those, 70 (19.7%) had a co-infection by 2 types, 37 (10.4%) by 3 types; 33 men (9.2%) by 4 types; 8 men (2.2%) by 5 types; 1 man (0.3%) by 6 types; 1 man (0.3%) by 7 types; 2 men (0.6%) by 8 types and 1 man (0.3%) by 9 types.Conclusion: the most frequent HPV types were 6, 16, 42 and 51. Co-infection was found in 59% of our patients. This information is vital to drive future public health policies including massive public vaccination campaign. |
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Freire, Marcos P. [UNIFESP]Pires, DanielForjaz, RaphaelSato, SergioCotrim, Ismael [UNIFESP]Stiepcich, MonicaScarpellini, BrunoTruzzi, Jose C. [UNIFESP]Fleury GrpAnhembi Morumbi Med SchUniversidade Federal de São Paulo (UNIFESP)2016-01-24T14:34:58Z2016-01-24T14:34:58Z2014-01-01International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 40, n. 1, p. 67-71, 2014.1677-5538http://repositorio.unifesp.br/handle/11600/37177http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.01.10S1677-5538.IBJU.2014.01.1010.1590/S1677-5538.IBJU.2014.01.10WOS:000335430800011Introduction: HPV infection is a highly prevalent sexually transmitted disease and there is evidence of the relationship of HPV infection and the development of genital warts, penile intraepitelial neoplasia, invasive penile carcinoma and cervical cancer. However, there is sparse data regarding the prevalence of HPV types and co-infection of different HPV types among men.Objectives: To assess the prevalence of HPV subtypes infections and rates of co-infection among men.Materials and Methods: 366 men were evaluated from March to October 2010. Men were referred to our institution for HPV diagnostic evaluation based on the following criteria: 1. presence of a genital wart; 2. presence of an atypical genital lesion; 3. absence of symptoms and a partner with a HPV diagnosis; 4. absence of symptoms and a desire to undergo a full STD diagnostic evaluation. Genital samples were collected from the urethra, penile shaft, scrotum and anus with Digene (R) collection and preservation kit and submitted to HPV genotype microarray detection (Papillocheck (R)). All men were tested for the low-risk HPV types 6-11-40-42-43-44 and for the high-risk HPV types 16-18-31-33-35-39-45-51-52-53-56-58-59-66-68-70-73-82.Results: of the 366 men, 11 were tested inconclusive and were excluded from the analysis. 256 men (72.1% of the men from the cohort referred to our institution) tested positive with genotype micro-array detection and 99 tested negative. the most prevalent HPV-subtypes in the studied population were 6, 42, 51 and 16. Co-infection was found in 153 men. of those, 70 (19.7%) had a co-infection by 2 types, 37 (10.4%) by 3 types; 33 men (9.2%) by 4 types; 8 men (2.2%) by 5 types; 1 man (0.3%) by 6 types; 1 man (0.3%) by 7 types; 2 men (0.6%) by 8 types and 1 man (0.3%) by 9 types.Conclusion: the most frequent HPV types were 6, 16, 42 and 51. Co-infection was found in 59% of our patients. This information is vital to drive future public health policies including massive public vaccination campaign.Fleury Grp, Div Urol, São Paulo, BrazilAnhembi Morumbi Med Sch, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of Science67-71engBrazilian Soc UrolInternational Braz J UrolDNA Probes, HPVInfectionMenGenital prevalence of HPV types and co-infection in meninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/371772022-07-08 10:28:57.044metadata only accessoai:repositorio.unifesp.br:11600/37177Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-07-08T13:28:57Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Genital prevalence of HPV types and co-infection in men |
title |
Genital prevalence of HPV types and co-infection in men |
spellingShingle |
Genital prevalence of HPV types and co-infection in men Freire, Marcos P. [UNIFESP] DNA Probes, HPV Infection Men |
title_short |
Genital prevalence of HPV types and co-infection in men |
title_full |
Genital prevalence of HPV types and co-infection in men |
title_fullStr |
Genital prevalence of HPV types and co-infection in men |
title_full_unstemmed |
Genital prevalence of HPV types and co-infection in men |
title_sort |
Genital prevalence of HPV types and co-infection in men |
author |
Freire, Marcos P. [UNIFESP] |
author_facet |
Freire, Marcos P. [UNIFESP] Pires, Daniel Forjaz, Raphael Sato, Sergio Cotrim, Ismael [UNIFESP] Stiepcich, Monica Scarpellini, Bruno Truzzi, Jose C. [UNIFESP] |
author_role |
author |
author2 |
Pires, Daniel Forjaz, Raphael Sato, Sergio Cotrim, Ismael [UNIFESP] Stiepcich, Monica Scarpellini, Bruno Truzzi, Jose C. [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Fleury Grp Anhembi Morumbi Med Sch Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Freire, Marcos P. [UNIFESP] Pires, Daniel Forjaz, Raphael Sato, Sergio Cotrim, Ismael [UNIFESP] Stiepcich, Monica Scarpellini, Bruno Truzzi, Jose C. [UNIFESP] |
dc.subject.eng.fl_str_mv |
DNA Probes, HPV Infection Men |
topic |
DNA Probes, HPV Infection Men |
description |
Introduction: HPV infection is a highly prevalent sexually transmitted disease and there is evidence of the relationship of HPV infection and the development of genital warts, penile intraepitelial neoplasia, invasive penile carcinoma and cervical cancer. However, there is sparse data regarding the prevalence of HPV types and co-infection of different HPV types among men.Objectives: To assess the prevalence of HPV subtypes infections and rates of co-infection among men.Materials and Methods: 366 men were evaluated from March to October 2010. Men were referred to our institution for HPV diagnostic evaluation based on the following criteria: 1. presence of a genital wart; 2. presence of an atypical genital lesion; 3. absence of symptoms and a partner with a HPV diagnosis; 4. absence of symptoms and a desire to undergo a full STD diagnostic evaluation. Genital samples were collected from the urethra, penile shaft, scrotum and anus with Digene (R) collection and preservation kit and submitted to HPV genotype microarray detection (Papillocheck (R)). All men were tested for the low-risk HPV types 6-11-40-42-43-44 and for the high-risk HPV types 16-18-31-33-35-39-45-51-52-53-56-58-59-66-68-70-73-82.Results: of the 366 men, 11 were tested inconclusive and were excluded from the analysis. 256 men (72.1% of the men from the cohort referred to our institution) tested positive with genotype micro-array detection and 99 tested negative. the most prevalent HPV-subtypes in the studied population were 6, 42, 51 and 16. Co-infection was found in 153 men. of those, 70 (19.7%) had a co-infection by 2 types, 37 (10.4%) by 3 types; 33 men (9.2%) by 4 types; 8 men (2.2%) by 5 types; 1 man (0.3%) by 6 types; 1 man (0.3%) by 7 types; 2 men (0.6%) by 8 types and 1 man (0.3%) by 9 types.Conclusion: the most frequent HPV types were 6, 16, 42 and 51. Co-infection was found in 59% of our patients. This information is vital to drive future public health policies including massive public vaccination campaign. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:58Z |
dc.date.available.fl_str_mv |
2016-01-24T14:34:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 40, n. 1, p. 67-71, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37177 http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.01.10 |
dc.identifier.issn.none.fl_str_mv |
1677-5538 |
dc.identifier.scielo.none.fl_str_mv |
S1677-5538.IBJU.2014.01.10 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1677-5538.IBJU.2014.01.10 |
dc.identifier.wos.none.fl_str_mv |
WOS:000335430800011 |
identifier_str_mv |
International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 40, n. 1, p. 67-71, 2014. 1677-5538 S1677-5538.IBJU.2014.01.10 10.1590/S1677-5538.IBJU.2014.01.10 WOS:000335430800011 |
url |
http://repositorio.unifesp.br/handle/11600/37177 http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.01.10 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
International Braz J Urol |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
67-71 |
dc.publisher.none.fl_str_mv |
Brazilian Soc Urol |
publisher.none.fl_str_mv |
Brazilian Soc Urol |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764144616669184 |