Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/32817 http://dx.doi.org/10.3748/wjg.v16.i29.3704 |
Resumo: | AIM: To evaluate the overlap of autoimmune hepatitis in hepatitis C virus (HCV)-infected patients with intense interface hepatitis.METHODS: Among 1759 patients with hepatitis C submitted to liver biopsy, 92 (5.2%) presented intense interface hepatitis. These patients were evaluated regarding the presence of antinuclear antibody (ANA), anti-smooth muscle antibody (SMA) and anti-liver/kidney microsomal antibody (LKM-1), levels of gamma-globulin and histological findings related to autoimmune hepatitis (plasma cell infiltrate and presence of rosettes).RESULTS: Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies (ANA = 12%, SMA = 5%, LKM-1 = 0%) and the median gamma-globulin level was within the normal range. Typical histological findings of autoimmune disease were observed in only two cases (2%). After applying the score for diagnosis of autoimmune hepatitis, only one patient was classified with a definitive diagnosis of autoimmune hepatitis. Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding. the presence of intense interface hepatitis was associated with more advanced age, both at the time of infection and at the time of the biopsy, and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION: Although possible, overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis, an unusual presentation which seems to be related to other host variables. (C) 2010 Baishideng. All rights reserved. |
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Badiani, Rosilene das Graças [UNIFESP]Becker, Vitoria [UNIFESP]Perez, Renata de Mello [UNIFESP]Matos, Carla Adriana Loureiro de [UNIFESP]Lemos, Lara B. [UNIFESP]Lanzoni, Valeria Pereira [UNIFESP]Andrade, Luis Eduardo C.Dellavance, AlessandraSilva, Antonio Eduardo Benedito [UNIFESP]Ferraz, Maria Lucia Gomes [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade Federal do Rio de Janeiro (UFRJ)Immunol Grp2016-01-24T14:05:19Z2016-01-24T14:05:19Z2010-08-07World Journal of Gastroenterology. Beijing: W J G Press, v. 16, n. 29, p. 3704-3708, 2010.1007-9327http://repositorio.unifesp.br/handle/11600/32817http://dx.doi.org/10.3748/wjg.v16.i29.370410.3748/wjg.v16.i29.3704WOS:000280712500013AIM: To evaluate the overlap of autoimmune hepatitis in hepatitis C virus (HCV)-infected patients with intense interface hepatitis.METHODS: Among 1759 patients with hepatitis C submitted to liver biopsy, 92 (5.2%) presented intense interface hepatitis. These patients were evaluated regarding the presence of antinuclear antibody (ANA), anti-smooth muscle antibody (SMA) and anti-liver/kidney microsomal antibody (LKM-1), levels of gamma-globulin and histological findings related to autoimmune hepatitis (plasma cell infiltrate and presence of rosettes).RESULTS: Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies (ANA = 12%, SMA = 5%, LKM-1 = 0%) and the median gamma-globulin level was within the normal range. Typical histological findings of autoimmune disease were observed in only two cases (2%). After applying the score for diagnosis of autoimmune hepatitis, only one patient was classified with a definitive diagnosis of autoimmune hepatitis. Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding. the presence of intense interface hepatitis was associated with more advanced age, both at the time of infection and at the time of the biopsy, and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION: Although possible, overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis, an unusual presentation which seems to be related to other host variables. (C) 2010 Baishideng. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo, Div Gastroenterol, BR-04023900 São Paulo, BrazilUniv Fed Rio de Janeiro, Dept Internal Med, BR-21941913 Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-04023900 São Paulo, BrazilImmunol Grp, Fleury Med & Hlth, BR-04344903 São Paulo, BrazilUniversidade Federal de São Paulo, Div Gastroenterol, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-04023900 São Paulo, BrazilWeb of Science3704-3708engW J G PressWorld Journal of GastroenterologyHepatitis CLiver biopsyAntinuclear antibodyAutoimmune hepatitisInterface hepatitisIs autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/328172023-02-15 10:56:35.575metadata only accessoai:repositorio.unifesp.br:11600/32817Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:24.258756Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis? |
title |
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis? |
spellingShingle |
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis? Badiani, Rosilene das Graças [UNIFESP] Hepatitis C Liver biopsy Antinuclear antibody Autoimmune hepatitis Interface hepatitis |
title_short |
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis? |
title_full |
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis? |
title_fullStr |
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis? |
title_full_unstemmed |
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis? |
title_sort |
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis? |
author |
Badiani, Rosilene das Graças [UNIFESP] |
author_facet |
Badiani, Rosilene das Graças [UNIFESP] Becker, Vitoria [UNIFESP] Perez, Renata de Mello [UNIFESP] Matos, Carla Adriana Loureiro de [UNIFESP] Lemos, Lara B. [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Andrade, Luis Eduardo C. Dellavance, Alessandra Silva, Antonio Eduardo Benedito [UNIFESP] Ferraz, Maria Lucia Gomes [UNIFESP] |
author_role |
author |
author2 |
Becker, Vitoria [UNIFESP] Perez, Renata de Mello [UNIFESP] Matos, Carla Adriana Loureiro de [UNIFESP] Lemos, Lara B. [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Andrade, Luis Eduardo C. Dellavance, Alessandra Silva, Antonio Eduardo Benedito [UNIFESP] Ferraz, Maria Lucia Gomes [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal do Rio de Janeiro (UFRJ) Immunol Grp |
dc.contributor.author.fl_str_mv |
Badiani, Rosilene das Graças [UNIFESP] Becker, Vitoria [UNIFESP] Perez, Renata de Mello [UNIFESP] Matos, Carla Adriana Loureiro de [UNIFESP] Lemos, Lara B. [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Andrade, Luis Eduardo C. Dellavance, Alessandra Silva, Antonio Eduardo Benedito [UNIFESP] Ferraz, Maria Lucia Gomes [UNIFESP] |
dc.subject.eng.fl_str_mv |
Hepatitis C Liver biopsy Antinuclear antibody Autoimmune hepatitis Interface hepatitis |
topic |
Hepatitis C Liver biopsy Antinuclear antibody Autoimmune hepatitis Interface hepatitis |
description |
AIM: To evaluate the overlap of autoimmune hepatitis in hepatitis C virus (HCV)-infected patients with intense interface hepatitis.METHODS: Among 1759 patients with hepatitis C submitted to liver biopsy, 92 (5.2%) presented intense interface hepatitis. These patients were evaluated regarding the presence of antinuclear antibody (ANA), anti-smooth muscle antibody (SMA) and anti-liver/kidney microsomal antibody (LKM-1), levels of gamma-globulin and histological findings related to autoimmune hepatitis (plasma cell infiltrate and presence of rosettes).RESULTS: Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies (ANA = 12%, SMA = 5%, LKM-1 = 0%) and the median gamma-globulin level was within the normal range. Typical histological findings of autoimmune disease were observed in only two cases (2%). After applying the score for diagnosis of autoimmune hepatitis, only one patient was classified with a definitive diagnosis of autoimmune hepatitis. Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding. the presence of intense interface hepatitis was associated with more advanced age, both at the time of infection and at the time of the biopsy, and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION: Although possible, overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis, an unusual presentation which seems to be related to other host variables. (C) 2010 Baishideng. All rights reserved. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-08-07 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:05:19Z |
dc.date.available.fl_str_mv |
2016-01-24T14:05:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
World Journal of Gastroenterology. Beijing: W J G Press, v. 16, n. 29, p. 3704-3708, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/32817 http://dx.doi.org/10.3748/wjg.v16.i29.3704 |
dc.identifier.issn.none.fl_str_mv |
1007-9327 |
dc.identifier.doi.none.fl_str_mv |
10.3748/wjg.v16.i29.3704 |
dc.identifier.wos.none.fl_str_mv |
WOS:000280712500013 |
identifier_str_mv |
World Journal of Gastroenterology. Beijing: W J G Press, v. 16, n. 29, p. 3704-3708, 2010. 1007-9327 10.3748/wjg.v16.i29.3704 WOS:000280712500013 |
url |
http://repositorio.unifesp.br/handle/11600/32817 http://dx.doi.org/10.3748/wjg.v16.i29.3704 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
World Journal of Gastroenterology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3704-3708 |
dc.publisher.none.fl_str_mv |
W J G Press |
publisher.none.fl_str_mv |
W J G Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460302317158400 |