Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties

• Autor(a) principal: Faintuch, Bluma L.
• Data de Publicação: 2014
• Outros Autores: Oliveira, Erica A., Munoz, Julian E., Travassos, Luiz R. [UNIFESP], Taborda, Carlos Pelleschi [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1093/mmy/myu024; http://repositorio.unifesp.br/handle/11600/37890
• topic: P10 peptide; P. brasiliensis; radiolabeling; biodistribution evaluation

Paracoccidioidomycosis (PCM) is a chronic granulomatous disease that is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis. It is endemic in some countries of Latin America and can cause a high-burden fungal infection with significant morbidity and mortality. the peptide P10, which demonstrates immune protection against experimental PCM, was radiolabeled with a radioisotope and evaluated in vivo. the radiolabeling was conducted to trace the pharmacokinetics of the molecule in principal organs and tissues. This was achieved with high radiochemical purity. Biodistribution and scintigraphic imaging showed fast blood clearance that was mainly renal; however, hepatobiliar excretion was also, with marked uptake in cervical lymph nodes. This profile may be useful for the development of a prophylactic drug or vaccine for patients exposed to PCM.