Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37149 http://dx.doi.org/10.1155/2014/632570 |
Resumo: | The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (SGC) as oil phase, and water in the ratios 30 : 25 : 45 and 40 : 50 : 10 with (OLS nu = RP-loaded opaque liquid system and TLS nu = RP-loaded transparent liquid system, respectively) and without (OLS and TLS, respectively) RP were studied. Samples were characterized using polarized light microscopy (PLM) and rheology analysis. in vitro safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. in vitro antioxidant activity was performed by the DPPH method. PLM analysis showed the presence of lamellar LCS just to TLS. Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations. the results showed that the incorporation of RP in LCS improved the safety profile of the drug. in vitro antioxidant activity suggests that LCS presented a higher capacity to maintain the antioxidant activity of RP. PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging. |
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Oliveira, Marcela B.Prado, Alice Haddad doBernegossi, JessicaSato, Claudia S.Brunetti, Iguatemy LourencoScarpa, Maria VirginiaLeonardi, Gislaine Ricci [UNIFESP]Friberg, Stig E.Chorilli, MarlusUNESPUniversidade Federal de São Paulo (UNIFESP)Norwegian Univ Sci & Technol NTNU2016-01-24T14:34:56Z2016-01-24T14:34:56Z2014-01-01Biomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2014.2314-6133http://repositorio.unifesp.br/handle/11600/37149http://dx.doi.org/10.1155/2014/632570WOS000333635900001.pdf10.1155/2014/632570WOS:000333635900001The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (SGC) as oil phase, and water in the ratios 30 : 25 : 45 and 40 : 50 : 10 with (OLS nu = RP-loaded opaque liquid system and TLS nu = RP-loaded transparent liquid system, respectively) and without (OLS and TLS, respectively) RP were studied. Samples were characterized using polarized light microscopy (PLM) and rheology analysis. in vitro safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. in vitro antioxidant activity was performed by the DPPH method. PLM analysis showed the presence of lamellar LCS just to TLS. Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations. the results showed that the incorporation of RP in LCS improved the safety profile of the drug. in vitro antioxidant activity suggests that LCS presented a higher capacity to maintain the antioxidant activity of RP. PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Programa de Apoio ao Desenvolvimento Cientifico (PADC-UNESP)UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14801902 Araraquara, SP, BrazilUNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP, BrazilFed Univ São Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, BR-09972270 Diadema, SP, BrazilNorwegian Univ Sci & Technol NTNU, Ugelstad Lab, N-7491 Trondheim, NorwayFed Univ São Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, BR-09972270 Diadema, SP, BrazilWeb of ScienceengHindawi Publishing CorporationBiomed Research InternationalTopical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aginginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000333635900001.pdfapplication/pdf2622740${dspace.ui.url}/bitstream/11600/37149/1/WOS000333635900001.pdf2d13fd24c3dd50a01c1f85b2cddcce55MD51open accessTEXTWOS000333635900001.pdf.txtWOS000333635900001.pdf.txtExtracted texttext/plain36878${dspace.ui.url}/bitstream/11600/37149/9/WOS000333635900001.pdf.txtb4523c0b634b99e7a6230e2769744f41MD59open accessTHUMBNAILWOS000333635900001.pdf.jpgWOS000333635900001.pdf.jpgIM Thumbnailimage/jpeg6977${dspace.ui.url}/bitstream/11600/37149/11/WOS000333635900001.pdf.jpgd0cf7ef8ab747562270edc0289ad644cMD511open access11600/371492023-06-05 19:34:48.233open accessoai:repositorio.unifesp.br:11600/37149Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:34:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging |
title |
Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging |
spellingShingle |
Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging Oliveira, Marcela B. |
title_short |
Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging |
title_full |
Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging |
title_fullStr |
Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging |
title_full_unstemmed |
Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging |
title_sort |
Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging |
author |
Oliveira, Marcela B. |
author_facet |
Oliveira, Marcela B. Prado, Alice Haddad do Bernegossi, Jessica Sato, Claudia S. Brunetti, Iguatemy Lourenco Scarpa, Maria Virginia Leonardi, Gislaine Ricci [UNIFESP] Friberg, Stig E. Chorilli, Marlus |
author_role |
author |
author2 |
Prado, Alice Haddad do Bernegossi, Jessica Sato, Claudia S. Brunetti, Iguatemy Lourenco Scarpa, Maria Virginia Leonardi, Gislaine Ricci [UNIFESP] Friberg, Stig E. Chorilli, Marlus |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
UNESP Universidade Federal de São Paulo (UNIFESP) Norwegian Univ Sci & Technol NTNU |
dc.contributor.author.fl_str_mv |
Oliveira, Marcela B. Prado, Alice Haddad do Bernegossi, Jessica Sato, Claudia S. Brunetti, Iguatemy Lourenco Scarpa, Maria Virginia Leonardi, Gislaine Ricci [UNIFESP] Friberg, Stig E. Chorilli, Marlus |
description |
The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (SGC) as oil phase, and water in the ratios 30 : 25 : 45 and 40 : 50 : 10 with (OLS nu = RP-loaded opaque liquid system and TLS nu = RP-loaded transparent liquid system, respectively) and without (OLS and TLS, respectively) RP were studied. Samples were characterized using polarized light microscopy (PLM) and rheology analysis. in vitro safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. in vitro antioxidant activity was performed by the DPPH method. PLM analysis showed the presence of lamellar LCS just to TLS. Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations. the results showed that the incorporation of RP in LCS improved the safety profile of the drug. in vitro antioxidant activity suggests that LCS presented a higher capacity to maintain the antioxidant activity of RP. PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:56Z |
dc.date.available.fl_str_mv |
2016-01-24T14:34:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37149 http://dx.doi.org/10.1155/2014/632570 |
dc.identifier.issn.none.fl_str_mv |
2314-6133 |
dc.identifier.file.none.fl_str_mv |
WOS000333635900001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1155/2014/632570 |
dc.identifier.wos.none.fl_str_mv |
WOS:000333635900001 |
identifier_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2014. 2314-6133 WOS000333635900001.pdf 10.1155/2014/632570 WOS:000333635900001 |
url |
http://repositorio.unifesp.br/handle/11600/37149 http://dx.doi.org/10.1155/2014/632570 |
dc.language.iso.fl_str_mv |
eng |
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Biomed Research International |
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openAccess |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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