Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

Detalhes bibliográficos
Autor(a) principal: Tufik, Sergio [UNIFESP]
Data de Publicação: 2009
Outros Autores: Andersen, Monica Levy [UNIFESP], Bittencourt, Lia Rita Azeredo [UNIFESP], Mello, Marco Tulio de [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0001-37652009000300016
http://repositorio.unifesp.br/handle/11600/5265
Resumo: Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.
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spelling Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of researchsleepsleep deprivationrebounddopamineerectioncorticosteronememorysonoprivação de sonorebotedopaminaereçãocorticosteronamemóriaSleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.O sono ocupa cerca de um terço de nossas vidas, entretanto seu impacto na saúde e sua influência nas condições patológicas ainda não foi completamente elucidado. A prevalência dos distúrbios de sono é cada vez maior, sobretudo nas regiões mais industrializadas, repercutindo diretamente no bem-estar da população. Este artigo tem como objetivo sintetizar e atualizar a literatura a respeito do método de privação de sono paradoxal e seu panorama de conseqüências desde comportamentais até genéticas em animais. Ainda, destacamos a contribuição e relevância dos estudos experimentais realizados por nosso grupo nas ultimas três décadas.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PsicobiologiaUNIFESP, EPM, Depto. de PsicobiologiaSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Academia Brasileira de CiênciasUniversidade Federal de São Paulo (UNIFESP)Tufik, Sergio [UNIFESP]Andersen, Monica Levy [UNIFESP]Bittencourt, Lia Rita Azeredo [UNIFESP]Mello, Marco Tulio de [UNIFESP]2015-06-14T13:41:11Z2015-06-14T13:41:11Z2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion521-538application/pdfhttp://dx.doi.org/10.1590/S0001-37652009000300016Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 521-538, 2009.10.1590/S0001-37652009000300016S0001-37652009000300016.pdf0001-3765S0001-37652009000300016http://repositorio.unifesp.br/handle/11600/5265WOS:000269462300016engAnais da Academia Brasileira de Ciênciasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T14:19:35Zoai:repositorio.unifesp.br/:11600/5265Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T14:19:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
title Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
spellingShingle Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
Tufik, Sergio [UNIFESP]
sleep
sleep deprivation
rebound
dopamine
erection
corticosterone
memory
sono
privação de sono
rebote
dopamina
ereção
corticosterona
memória
title_short Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
title_full Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
title_fullStr Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
title_full_unstemmed Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
title_sort Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
author Tufik, Sergio [UNIFESP]
author_facet Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
author_role author
author2 Andersen, Monica Levy [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
dc.subject.por.fl_str_mv sleep
sleep deprivation
rebound
dopamine
erection
corticosterone
memory
sono
privação de sono
rebote
dopamina
ereção
corticosterona
memória
topic sleep
sleep deprivation
rebound
dopamine
erection
corticosterone
memory
sono
privação de sono
rebote
dopamina
ereção
corticosterona
memória
description Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.
publishDate 2009
dc.date.none.fl_str_mv 2009-09-01
2015-06-14T13:41:11Z
2015-06-14T13:41:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0001-37652009000300016
Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 521-538, 2009.
10.1590/S0001-37652009000300016
S0001-37652009000300016.pdf
0001-3765
S0001-37652009000300016
http://repositorio.unifesp.br/handle/11600/5265
WOS:000269462300016
url http://dx.doi.org/10.1590/S0001-37652009000300016
http://repositorio.unifesp.br/handle/11600/5265
identifier_str_mv Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 521-538, 2009.
10.1590/S0001-37652009000300016
S0001-37652009000300016.pdf
0001-3765
S0001-37652009000300016
WOS:000269462300016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais da Academia Brasileira de Ciências
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 521-538
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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