Neuroimagem do transportador de dopamina na doença de Parkinson: primeiro estudo com [99mTc]-TRODAT-1 e SPECT no Brasil

• Autor(a) principal: Shih, Ming Chi [UNIFESP]
• Data de Publicação: 2006
• Outros Autores: Amaro Junior, Edson, Ferraz, Henrique Ballalai [UNIFESP], Hoexter, Marcelo Queiroz [UNIFESP], Goulart, Fabricio Oliveira [UNIFESP], Wagner, Jairo, Lin, Li Fu, Fu, Ying Kai, Mari, Jair de Jesus [UNIFESP], Lacerda, Acioly Luiz Tavares de [UNIFESP], Tufik, Sergio [UNIFESP], Bressan, Rodrigo Affonseca [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-282X2006000400021; http://repositorio.unifesp.br/handle/11600/3256
• topic: dopamina; dopamine transporter; Parkinson's disease; diagnosis; SPECT; dopamina; receptor dopaminérgico; doença de Parkinson; diagnóstico; SPECT

BACKGROUND: Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss in vivo in Parkinson s disease (PD). OBJECTIVE: To evaluate DAT density in vivo using [99mTc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD. METHOD: Fifteen PD patients and 15 matched healthy controls scanned with [99mTc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales. RESULTS: PD patients had significantly lower striatal DAT-BP (mean±SD) (0.38±0.12) compared to controls (BP=0.84±0.16; p<0.01). A 100% sensitivity and 100% specificity was obtained to discriminate PD cases from controls. Negative correlations between striatal DAT-BP and PD severity (rho= -0.7, p<0.001) and motor scales (rho= -0.80, p<0.001) were found. CONCLUSION: [99mTc]TRODAT-1 SPECTs scanning was able to discriminate PD patients from controls. The technique is a powerful instrument to measure DAT density that can be used in clinical and research settings in Brazil.