Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Rogerio Silicani [UNIFESP]
Data de Publicação: 2011
Outros Autores: Abucham, Julio [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27302011000400005
http://repositorio.unifesp.br/handle/11600/6515
Resumo: OBJETIVE: To evaluate the effect of clomiphene in men with hypogonadism and conventionally treated nonfunctioning pituitary adenomas (NFPA). PATIENTS AND METHODS: Open label, single-arm, prospective trial. Nine hypogonadal men (testosterone < 300 ng/dL and low/normal LH) with previously treated NFPA. Clomiphene (50 mg/day orally) for 12 weeks. Testosterone, estradiol, LH, FSH, prolactin and erectile function were evaluated before and after 10 days, 4, 8 and 12 weeks of clomiphene treatment. RESULTS: After clomiphene treatment, testosterone and erectile function improved in only one patient. In the remaining eight patients, testosterone levels decreased whereas LH, FSH, and estradiol remained unchanged. Insulin sensitivity increased in unresponsive patients. CONCLUSIONS: Compared with hypogonadal men with prolactinomas under dopaminergic therapy, clomiphene treatment failed to restore normal testosterone levels in most patients with conventionally treated NFPA.
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spelling Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomasClomifeno não reverte o hipogonadismo na maioria dos homens com adenomas pituitários não funcionais tratados de forma convencionalNonfunctioning pituitary adenomahypogonadotropic hypogonadismclomiphenetestosteroneAdenoma hipofisário não funcionantehipogonadismo hipogonadotróficoclomifenotestosteronaOBJETIVE: To evaluate the effect of clomiphene in men with hypogonadism and conventionally treated nonfunctioning pituitary adenomas (NFPA). PATIENTS AND METHODS: Open label, single-arm, prospective trial. Nine hypogonadal men (testosterone < 300 ng/dL and low/normal LH) with previously treated NFPA. Clomiphene (50 mg/day orally) for 12 weeks. Testosterone, estradiol, LH, FSH, prolactin and erectile function were evaluated before and after 10 days, 4, 8 and 12 weeks of clomiphene treatment. RESULTS: After clomiphene treatment, testosterone and erectile function improved in only one patient. In the remaining eight patients, testosterone levels decreased whereas LH, FSH, and estradiol remained unchanged. Insulin sensitivity increased in unresponsive patients. CONCLUSIONS: Compared with hypogonadal men with prolactinomas under dopaminergic therapy, clomiphene treatment failed to restore normal testosterone levels in most patients with conventionally treated NFPA.OBJETIVO: Avaliar o efeito do clomifeno em homens com hipogonadismo e adenoma hipofisário não funcionante (NFPA) previamente tratados. PACIENTES E MÉTODOS: Aberto, braço único, prospectivo. Nove homens hipogonádicos (testosterona < 300 ng/dL e LH normal/baixo) com NFPA previamente tratados. Clomifeno (50 mg/dia oral) por 12 semanas. Testosterona, estradiol, LH, FSH, prolactina e função erétil foram avaliados antes e após 10 dias, 4, 8 e 12 semanas de clomifeno. RESULTADOS: Após clomifeno, a testosterona e a função erétil melhoraram em um paciente. Em outros oito pacientes, os níveis de testosterona reduziram enquanto os níveis de LH, FSH, e estradiol permaneceram inalterados. A sensibilidade à insulina aumentou nos não respondedores. CONCLUSÕES: Em contraste com homens hipogonádicos com prolactinomas tratados com agonistas dopaminérgicos, a maioria dos hipogonádicos com NFPA falha em restaurar os níveis de testosterona durante o uso de clomifeno.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of MedicineUNIFESP, EPM, Department of MedicineSciELOCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sociedade Brasileira de Endocrinologia e MetabologiaUniversidade Federal de São Paulo (UNIFESP)Ribeiro, Rogerio Silicani [UNIFESP]Abucham, Julio [UNIFESP]2015-06-14T13:43:08Z2015-06-14T13:43:08Z2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion266-271application/pdfhttp://dx.doi.org/10.1590/S0004-27302011000400005Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 55, n. 4, p. 266-271, 2011.10.1590/S0004-27302011000400005S0004-27302011000400005.pdf0004-2730S0004-27302011000400005http://repositorio.unifesp.br/handle/11600/6515WOS:000292937900005engArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T22:20:13Zoai:repositorio.unifesp.br/:11600/6515Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T22:20:13Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
Clomifeno não reverte o hipogonadismo na maioria dos homens com adenomas pituitários não funcionais tratados de forma convencional
title Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
spellingShingle Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
Ribeiro, Rogerio Silicani [UNIFESP]
Nonfunctioning pituitary adenoma
hypogonadotropic hypogonadism
clomiphene
testosterone
Adenoma hipofisário não funcionante
hipogonadismo hipogonadotrófico
clomifeno
testosterona
title_short Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title_full Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title_fullStr Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title_full_unstemmed Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
title_sort Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas
author Ribeiro, Rogerio Silicani [UNIFESP]
author_facet Ribeiro, Rogerio Silicani [UNIFESP]
Abucham, Julio [UNIFESP]
author_role author
author2 Abucham, Julio [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Ribeiro, Rogerio Silicani [UNIFESP]
Abucham, Julio [UNIFESP]
dc.subject.por.fl_str_mv Nonfunctioning pituitary adenoma
hypogonadotropic hypogonadism
clomiphene
testosterone
Adenoma hipofisário não funcionante
hipogonadismo hipogonadotrófico
clomifeno
testosterona
topic Nonfunctioning pituitary adenoma
hypogonadotropic hypogonadism
clomiphene
testosterone
Adenoma hipofisário não funcionante
hipogonadismo hipogonadotrófico
clomifeno
testosterona
description OBJETIVE: To evaluate the effect of clomiphene in men with hypogonadism and conventionally treated nonfunctioning pituitary adenomas (NFPA). PATIENTS AND METHODS: Open label, single-arm, prospective trial. Nine hypogonadal men (testosterone < 300 ng/dL and low/normal LH) with previously treated NFPA. Clomiphene (50 mg/day orally) for 12 weeks. Testosterone, estradiol, LH, FSH, prolactin and erectile function were evaluated before and after 10 days, 4, 8 and 12 weeks of clomiphene treatment. RESULTS: After clomiphene treatment, testosterone and erectile function improved in only one patient. In the remaining eight patients, testosterone levels decreased whereas LH, FSH, and estradiol remained unchanged. Insulin sensitivity increased in unresponsive patients. CONCLUSIONS: Compared with hypogonadal men with prolactinomas under dopaminergic therapy, clomiphene treatment failed to restore normal testosterone levels in most patients with conventionally treated NFPA.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
2015-06-14T13:43:08Z
2015-06-14T13:43:08Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27302011000400005
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 55, n. 4, p. 266-271, 2011.
10.1590/S0004-27302011000400005
S0004-27302011000400005.pdf
0004-2730
S0004-27302011000400005
http://repositorio.unifesp.br/handle/11600/6515
WOS:000292937900005
url http://dx.doi.org/10.1590/S0004-27302011000400005
http://repositorio.unifesp.br/handle/11600/6515
identifier_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 55, n. 4, p. 266-271, 2011.
10.1590/S0004-27302011000400005
S0004-27302011000400005.pdf
0004-2730
S0004-27302011000400005
WOS:000292937900005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 266-271
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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