Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | https://repositorio.unifesp.br/handle/11600/34639 https://dx.doi.org/10.1038/tp.2012.21 |
Resumo: | We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012 |
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Almeida, Sandro Soares [UNIFESP]Naffah-Mazzacoratti, Maria da Graca [UNIFESP]Guimarães, Paola Bianchi [UNIFESP]Wasinski, Frederick [UNIFESP]Pereira, Flavia Enira Gomes [UNIFESP]Canzian, Mauro [UNIFESP]Centeno, Ricardo Silva [UNIFESP]Carrete Junior, Henrique [UNIFESP]Yacubian, Elza Márcia Targas [UNIFESP]Carmona, Adriana Karaoglanovic [UNIFESP]Vieira, Renata de Freitas Fischer [UNIFESP]Nakaie, Clovis Ryuichi [UNIFESP]Sabatini, Regiane Angelica [UNIFESP]Perosa, Sandra Regina [UNIFESP]Bacurau, Reury Frank PereiraGouveia, Telma Luciana Furtado [UNIFESP]Gallo, Gloria [UNIFESP]Wuertele, Martin [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]Silva Junior, Jose Antonio [UNIFESP]Pesquero, João Bosco [UNIFESP]Araujo, Ronaldo de Carvalho [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Nove de Julho Univ UNINOVE2016-01-24T14:17:56Z2016-01-24T14:17:56Z2012-03-01Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012.2158-3188https://repositorio.unifesp.br/handle/11600/34639https://dx.doi.org/10.1038/tp.2012.21WOS000315990800009.pdf10.1038/tp.2012.21WOS:000315990800009We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012INNTConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Biophys, BR-04023032 São Paulo, BrazilUniversidade Federal de São Paulo, BR-04023032 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-04023032 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023032 São Paulo, BrazilUniv São Paulo, Sch Arts Sci & Humanities, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Sci & Technol, BR-04023032 São Paulo, BrazilNove de Julho Univ UNINOVE, Dept Rehabil Sci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biophys, BR-04023032 São Paulo, BrazilUniversidade Federal de São Paulo, BR-04023032 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, BR-04023032 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023032 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Sci & Technol, BR-04023032 São Paulo, BrazilWeb of Science5engNature Publishing GroupTranslational PsychiatryAngiotensin I-converting enzymeCarbamazepineEpilepsyTLECarbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000315990800009.pdfapplication/pdf348708${dspace.ui.url}/bitstream/11600/34639/1/WOS000315990800009.pdfb205431041c074c8b79a38d030306d18MD51open accessTEXTWOS000315990800009.pdf.txtWOS000315990800009.pdf.txtExtracted texttext/plain19977${dspace.ui.url}/bitstream/11600/34639/2/WOS000315990800009.pdf.txtc0cacd4c7bba2f35f4d4cabe5c9fe9b4MD52open access11600/346392023-04-20 18:57:26.308open accessoai:repositorio.unifesp.br:11600/34639Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:37:24.838348Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.en.fl_str_mv |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy |
| title |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy |
| spellingShingle |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy Almeida, Sandro Soares [UNIFESP] Angiotensin I-converting enzyme Carbamazepine Epilepsy TLE |
| title_short |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy |
| title_full |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy |
| title_fullStr |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy |
| title_full_unstemmed |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy |
| title_sort |
Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy |
| author |
Almeida, Sandro Soares [UNIFESP] |
| author_facet |
Almeida, Sandro Soares [UNIFESP] Naffah-Mazzacoratti, Maria da Graca [UNIFESP] Guimarães, Paola Bianchi [UNIFESP] Wasinski, Frederick [UNIFESP] Pereira, Flavia Enira Gomes [UNIFESP] Canzian, Mauro [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Carmona, Adriana Karaoglanovic [UNIFESP] Vieira, Renata de Freitas Fischer [UNIFESP] Nakaie, Clovis Ryuichi [UNIFESP] Sabatini, Regiane Angelica [UNIFESP] Perosa, Sandra Regina [UNIFESP] Bacurau, Reury Frank Pereira Gouveia, Telma Luciana Furtado [UNIFESP] Gallo, Gloria [UNIFESP] Wuertele, Martin [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Silva Junior, Jose Antonio [UNIFESP] Pesquero, João Bosco [UNIFESP] Araujo, Ronaldo de Carvalho [UNIFESP] |
| author_role |
author |
| author2 |
Naffah-Mazzacoratti, Maria da Graca [UNIFESP] Guimarães, Paola Bianchi [UNIFESP] Wasinski, Frederick [UNIFESP] Pereira, Flavia Enira Gomes [UNIFESP] Canzian, Mauro [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Carmona, Adriana Karaoglanovic [UNIFESP] Vieira, Renata de Freitas Fischer [UNIFESP] Nakaie, Clovis Ryuichi [UNIFESP] Sabatini, Regiane Angelica [UNIFESP] Perosa, Sandra Regina [UNIFESP] Bacurau, Reury Frank Pereira Gouveia, Telma Luciana Furtado [UNIFESP] Gallo, Gloria [UNIFESP] Wuertele, Martin [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Silva Junior, Jose Antonio [UNIFESP] Pesquero, João Bosco [UNIFESP] Araujo, Ronaldo de Carvalho [UNIFESP] |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Nove de Julho Univ UNINOVE |
| dc.contributor.author.fl_str_mv |
Almeida, Sandro Soares [UNIFESP] Naffah-Mazzacoratti, Maria da Graca [UNIFESP] Guimarães, Paola Bianchi [UNIFESP] Wasinski, Frederick [UNIFESP] Pereira, Flavia Enira Gomes [UNIFESP] Canzian, Mauro [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Carmona, Adriana Karaoglanovic [UNIFESP] Vieira, Renata de Freitas Fischer [UNIFESP] Nakaie, Clovis Ryuichi [UNIFESP] Sabatini, Regiane Angelica [UNIFESP] Perosa, Sandra Regina [UNIFESP] Bacurau, Reury Frank Pereira Gouveia, Telma Luciana Furtado [UNIFESP] Gallo, Gloria [UNIFESP] Wuertele, Martin [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Silva Junior, Jose Antonio [UNIFESP] Pesquero, João Bosco [UNIFESP] Araujo, Ronaldo de Carvalho [UNIFESP] |
| dc.subject.eng.fl_str_mv |
Angiotensin I-converting enzyme Carbamazepine Epilepsy TLE |
| topic |
Angiotensin I-converting enzyme Carbamazepine Epilepsy TLE |
| description |
We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012 |
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2012 |
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2012-03-01 |
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2016-01-24T14:17:56Z |
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2016-01-24T14:17:56Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012. |
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https://repositorio.unifesp.br/handle/11600/34639 https://dx.doi.org/10.1038/tp.2012.21 |
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2158-3188 |
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WOS000315990800009.pdf |
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10.1038/tp.2012.21 |
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WOS:000315990800009 |
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Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012. 2158-3188 WOS000315990800009.pdf 10.1038/tp.2012.21 WOS:000315990800009 |
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https://repositorio.unifesp.br/handle/11600/34639 https://dx.doi.org/10.1038/tp.2012.21 |
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