CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

• Autor(a) principal: Mandorwski, Sandra [UNIFESP]
• Data de Publicação: 2002
• Outros Autores: Lourenço, Laércio Gomes [UNIFESP], Forones, Nora Manoukian [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-28032002000100004; http://repositorio.unifesp.br/handle/11600/1368
• topic: Antigens, tumor-associated, carbohydrate; Carcinoembryonic antigen; Tumor markers, biological; Peritoneal lavage; Stomach neoplasms; Antígenos glicosídicos associados a tumores; Antígeno carcinoembrionário; Marcadores biológicos de tumor; Lavagem peritonial; Neoplasias gástricas

Background - The treatment and the prognosis of gastric cancer patients depends mainly on clinical stage. Serum and peritoneal tumoral markers levels can be helpful to evaluate individual risk for recurrence. Aims - To evaluate the sensibility of the tumoral markers in the serum and in the peritoneal washing on diagnosis of gastric cancer. Patients and Methods - Forty patients with adenocarcinoma of the stomach (11 stage I or II and 29 III or IV) and 24 patients with benign diseases were studied prospectively. All of them were submitted to laparotomy. Blood and peritoneal washed was collected during surgery before tumoral resection, for determination of CEA and CA72-4. Results - CEA and CA 72-4 serum levels were elevated in 25% and 47,5% respectively. Through the curves ROC, we defined the cut-off values for the markers in washed peritoneal fluid. Through these values CEA and CA72-4 rose in 60% and 57.5% respectively. The values of CEA and of CA 72-4 in the serum and in washed peritoneal fluid were higher in cancer patients stage III and IV. CEA levels in the peritoneal washed fluid were higher in the patients with tumor T3-4. Washed peritoneal CA72-4 differed the control group from the cancer group. Conclusion - CA72-4 was the most sensitive marker in the serum of the patients with gastric cancer. Otherwise in the washing peritoneal fluid the most sensitive marker was CEA. These levels were higher in patients with surpass the serosa and lower in patients with mucosa or muscular tumors.