Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37337 http://dx.doi.org/10.1016/j.pbb.2013.12.007 |
Resumo: | Chronic drug exposure and drug withdrawal induce expressive neuronal plasticity which could be considered as both functional and pathological responses. It is well established that neuronal plasticity in the limbic system plays a pivotal role in relapse as well as in compulsive characteristics of drug addiction. Although increases in FosB/DeltaFosB expression constitute one of the most important forms of neuronal plasticity in drug addiction, it is unclear whether they represent functional or pathological plasticity. It is of noteworthy importance the individual differences in the transition from recreational use to drug addiction. These differences have been reported in studies involving the ethanol-induced locomotor sensitization paradigm. in the present study we investigated whether sensitized and non-sensitized mice differ in terms of FosB/DeltaFosB expression. Adult male outbred Swiss mice were daily treated with ethanol or saline for 21 days. According to the locomotor activity in the acquisition phase, they were classified as sensitized (EtOH_High) or non-sensitized (EtOH_Low). After 18 h or 5 days, their brains were processed for FosB/DeltaFosB immunohistochemistry. On the 5th day of withdrawal, we could observe increased FosB/DeltaFosB expression in the EtOH_High group (in the motor cortex), in the EtOH_Low group (in the ventral tegmental area), and in both groups (in the striatum). Differences were more consistent in the EtOH_Low group. Therefore, behavioral variability observed in the acquisition phase of ethanol-induced locomotor sensitization was accompanied by differential neuronal plasticity during withdrawal period. Furthermore, distinct patterns of FosB/DeltaFosB expression detected in sensitized and non-sensitized mice seem to be more related to withdrawal period rather than to chronic drug exposure. Finally, increases in FosB/DeltaFosB expression during withdrawal period could be considered as being due to both functional and pathological plasticity. (C) 2013 Elsevier Inc. All rights reserved. |
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Pauli, Ricardo Fontão de [UNIFESP]Coelhoso, Cássia Canha [UNIFESP]Coelho, Carolina Tesone [UNIFESP]Linardi, Alessandra [UNIFESP]Mello, Luiz Eugenio Araujo de Moraes [UNIFESP]Silveira, Dartiu Xavier da [UNIFESP]Santos-Junior, Jair Guilherme [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Fac Med Sci Santa Casa São Paulo2016-01-24T14:35:10Z2016-01-24T14:35:10Z2014-02-01Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 117, p. 70-78, 2014.0091-3057http://repositorio.unifesp.br/handle/11600/37337http://dx.doi.org/10.1016/j.pbb.2013.12.007WOS000331501500010.pdf10.1016/j.pbb.2013.12.007WOS:000331501500010Chronic drug exposure and drug withdrawal induce expressive neuronal plasticity which could be considered as both functional and pathological responses. It is well established that neuronal plasticity in the limbic system plays a pivotal role in relapse as well as in compulsive characteristics of drug addiction. Although increases in FosB/DeltaFosB expression constitute one of the most important forms of neuronal plasticity in drug addiction, it is unclear whether they represent functional or pathological plasticity. It is of noteworthy importance the individual differences in the transition from recreational use to drug addiction. These differences have been reported in studies involving the ethanol-induced locomotor sensitization paradigm. in the present study we investigated whether sensitized and non-sensitized mice differ in terms of FosB/DeltaFosB expression. Adult male outbred Swiss mice were daily treated with ethanol or saline for 21 days. According to the locomotor activity in the acquisition phase, they were classified as sensitized (EtOH_High) or non-sensitized (EtOH_Low). After 18 h or 5 days, their brains were processed for FosB/DeltaFosB immunohistochemistry. On the 5th day of withdrawal, we could observe increased FosB/DeltaFosB expression in the EtOH_High group (in the motor cortex), in the EtOH_Low group (in the ventral tegmental area), and in both groups (in the striatum). Differences were more consistent in the EtOH_Low group. Therefore, behavioral variability observed in the acquisition phase of ethanol-induced locomotor sensitization was accompanied by differential neuronal plasticity during withdrawal period. Furthermore, distinct patterns of FosB/DeltaFosB expression detected in sensitized and non-sensitized mice seem to be more related to withdrawal period rather than to chronic drug exposure. Finally, increases in FosB/DeltaFosB expression during withdrawal period could be considered as being due to both functional and pathological plasticity. (C) 2013 Elsevier Inc. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Psychiat & Med Psychol, BR-04038020 São Paulo, BrazilUniversidade Federal de São Paulo, Neurobiol Lab, BR-04039032 São Paulo, BrazilFac Med Sci Santa Casa São Paulo, Dept Physiol Sci, BR-01221020 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat & Med Psychol, BR-04038020 São Paulo, BrazilUniversidade Federal de São Paulo, Neurobiol Lab, BR-04039032 São Paulo, BrazilWeb of Science70-78engElsevier B.V.Pharmacology Biochemistry and Behaviorhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessFosBDeltaFosBLocomotor sensitizationWithdrawalBehavioral variabilityMiceWithdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitizationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000331501500010.pdfapplication/pdf1298195${dspace.ui.url}/bitstream/11600/37337/1/WOS000331501500010.pdf4b12c29e4b4188c86f9dc4a113cd4216MD51open accessTEXTWOS000331501500010.pdf.txtWOS000331501500010.pdf.txtExtracted texttext/plain54787${dspace.ui.url}/bitstream/11600/37337/2/WOS000331501500010.pdf.txt5173ae6742a09eea69cebf701984e4aaMD52open access11600/373372022-09-27 09:48:33.329open accessoai:repositorio.unifesp.br:11600/37337Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-09-27T12:48:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization |
title |
Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization |
spellingShingle |
Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization Pauli, Ricardo Fontão de [UNIFESP] FosB DeltaFosB Locomotor sensitization Withdrawal Behavioral variability Mice |
title_short |
Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization |
title_full |
Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization |
title_fullStr |
Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization |
title_full_unstemmed |
Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization |
title_sort |
Withdrawal induces distinct patterns of FosB/Delta FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization |
author |
Pauli, Ricardo Fontão de [UNIFESP] |
author_facet |
Pauli, Ricardo Fontão de [UNIFESP] Coelhoso, Cássia Canha [UNIFESP] Coelho, Carolina Tesone [UNIFESP] Linardi, Alessandra [UNIFESP] Mello, Luiz Eugenio Araujo de Moraes [UNIFESP] Silveira, Dartiu Xavier da [UNIFESP] Santos-Junior, Jair Guilherme [UNIFESP] |
author_role |
author |
author2 |
Coelhoso, Cássia Canha [UNIFESP] Coelho, Carolina Tesone [UNIFESP] Linardi, Alessandra [UNIFESP] Mello, Luiz Eugenio Araujo de Moraes [UNIFESP] Silveira, Dartiu Xavier da [UNIFESP] Santos-Junior, Jair Guilherme [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Fac Med Sci Santa Casa São Paulo |
dc.contributor.author.fl_str_mv |
Pauli, Ricardo Fontão de [UNIFESP] Coelhoso, Cássia Canha [UNIFESP] Coelho, Carolina Tesone [UNIFESP] Linardi, Alessandra [UNIFESP] Mello, Luiz Eugenio Araujo de Moraes [UNIFESP] Silveira, Dartiu Xavier da [UNIFESP] Santos-Junior, Jair Guilherme [UNIFESP] |
dc.subject.eng.fl_str_mv |
FosB DeltaFosB Locomotor sensitization Withdrawal Behavioral variability Mice |
topic |
FosB DeltaFosB Locomotor sensitization Withdrawal Behavioral variability Mice |
description |
Chronic drug exposure and drug withdrawal induce expressive neuronal plasticity which could be considered as both functional and pathological responses. It is well established that neuronal plasticity in the limbic system plays a pivotal role in relapse as well as in compulsive characteristics of drug addiction. Although increases in FosB/DeltaFosB expression constitute one of the most important forms of neuronal plasticity in drug addiction, it is unclear whether they represent functional or pathological plasticity. It is of noteworthy importance the individual differences in the transition from recreational use to drug addiction. These differences have been reported in studies involving the ethanol-induced locomotor sensitization paradigm. in the present study we investigated whether sensitized and non-sensitized mice differ in terms of FosB/DeltaFosB expression. Adult male outbred Swiss mice were daily treated with ethanol or saline for 21 days. According to the locomotor activity in the acquisition phase, they were classified as sensitized (EtOH_High) or non-sensitized (EtOH_Low). After 18 h or 5 days, their brains were processed for FosB/DeltaFosB immunohistochemistry. On the 5th day of withdrawal, we could observe increased FosB/DeltaFosB expression in the EtOH_High group (in the motor cortex), in the EtOH_Low group (in the ventral tegmental area), and in both groups (in the striatum). Differences were more consistent in the EtOH_Low group. Therefore, behavioral variability observed in the acquisition phase of ethanol-induced locomotor sensitization was accompanied by differential neuronal plasticity during withdrawal period. Furthermore, distinct patterns of FosB/DeltaFosB expression detected in sensitized and non-sensitized mice seem to be more related to withdrawal period rather than to chronic drug exposure. Finally, increases in FosB/DeltaFosB expression during withdrawal period could be considered as being due to both functional and pathological plasticity. (C) 2013 Elsevier Inc. All rights reserved. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-02-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:35:10Z |
dc.date.available.fl_str_mv |
2016-01-24T14:35:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 117, p. 70-78, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37337 http://dx.doi.org/10.1016/j.pbb.2013.12.007 |
dc.identifier.issn.none.fl_str_mv |
0091-3057 |
dc.identifier.file.none.fl_str_mv |
WOS000331501500010.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.pbb.2013.12.007 |
dc.identifier.wos.none.fl_str_mv |
WOS:000331501500010 |
identifier_str_mv |
Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 117, p. 70-78, 2014. 0091-3057 WOS000331501500010.pdf 10.1016/j.pbb.2013.12.007 WOS:000331501500010 |
url |
http://repositorio.unifesp.br/handle/11600/37337 http://dx.doi.org/10.1016/j.pbb.2013.12.007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Pharmacology Biochemistry and Behavior |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
70-78 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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