Cytogenetic biomonitoring in oral mucosa cells following dental X-ray

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Daniel Araki [UNIFESP]
Data de Publicação: 2012
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1259/dmfr/14555883
http://repositorio.unifesp.br/handle/11600/34648
Resumo: Objectives: in the past decades, X-rays have been used widely for diagnosis in dentistry. However, it is well known that ionizing radiation causes damage (including single-and double-strand breaks) to deoxyribonucleic acid (DNA) and DNA-protein crosslinks, and induces cellular death. Therefore, outlining the cytogenetic effects induced by X-ray is necessary to identify the degree of cancer risk and minimize potential risks to patients and clinicians. To date, a variety of assays have been proposed in cytogenetic biomonitoring studies, including those that assess metaphase chromosomal aberrations and sister chromatid exchanges, and micronucleus and single-cell gel (comet) assay.Methods: Cytogenetic biomonitoring studies focusing on oral mucosa cells in individuals exposed to dental X-ray were reviewed.Results: Dental X-ray can induce DNA damage and cytotoxicity in oral mucosa cells.Conclusion: These results will contribute to a better understanding of X-ray-induced effects upon the cellular system in individuals continually exposed to known genotoxic/cytotoxic agents. Dentomaxillofacial Radiology (2012) 41, 181-184. doi: 10.1259/dmfr/14555883
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spelling Cytogenetic biomonitoring in oral mucosa cells following dental X-raydental X-raycytogenetic biomonitoringObjectives: in the past decades, X-rays have been used widely for diagnosis in dentistry. However, it is well known that ionizing radiation causes damage (including single-and double-strand breaks) to deoxyribonucleic acid (DNA) and DNA-protein crosslinks, and induces cellular death. Therefore, outlining the cytogenetic effects induced by X-ray is necessary to identify the degree of cancer risk and minimize potential risks to patients and clinicians. To date, a variety of assays have been proposed in cytogenetic biomonitoring studies, including those that assess metaphase chromosomal aberrations and sister chromatid exchanges, and micronucleus and single-cell gel (comet) assay.Methods: Cytogenetic biomonitoring studies focusing on oral mucosa cells in individuals exposed to dental X-ray were reviewed.Results: Dental X-ray can induce DNA damage and cytotoxicity in oral mucosa cells.Conclusion: These results will contribute to a better understanding of X-ray-induced effects upon the cellular system in individuals continually exposed to known genotoxic/cytotoxic agents. Dentomaxillofacial Radiology (2012) 41, 181-184. doi: 10.1259/dmfr/14555883Universidade Federal de São Paulo, Dept Biociencias, BR-11060001 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, BrazilWeb of ScienceBritish Inst RadiologyUniversidade Federal de São Paulo (UNIFESP)Ribeiro, Daniel Araki [UNIFESP]2016-01-24T14:17:57Z2016-01-24T14:17:57Z2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion181-184http://dx.doi.org/10.1259/dmfr/14555883Dentomaxillofacial Radiology. London: British Inst Radiology, v. 41, n. 3, p. 181-184, 2012.10.1259/dmfr/145558830250-832Xhttp://repositorio.unifesp.br/handle/11600/34648WOS:000300930700001engDentomaxillofacial Radiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-03-27T13:40:27Zoai:repositorio.unifesp.br/:11600/34648Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-03-27T13:40:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Cytogenetic biomonitoring in oral mucosa cells following dental X-ray
title Cytogenetic biomonitoring in oral mucosa cells following dental X-ray
spellingShingle Cytogenetic biomonitoring in oral mucosa cells following dental X-ray
Ribeiro, Daniel Araki [UNIFESP]
dental X-ray
cytogenetic biomonitoring
title_short Cytogenetic biomonitoring in oral mucosa cells following dental X-ray
title_full Cytogenetic biomonitoring in oral mucosa cells following dental X-ray
title_fullStr Cytogenetic biomonitoring in oral mucosa cells following dental X-ray
title_full_unstemmed Cytogenetic biomonitoring in oral mucosa cells following dental X-ray
title_sort Cytogenetic biomonitoring in oral mucosa cells following dental X-ray
author Ribeiro, Daniel Araki [UNIFESP]
author_facet Ribeiro, Daniel Araki [UNIFESP]
author_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Ribeiro, Daniel Araki [UNIFESP]
dc.subject.por.fl_str_mv dental X-ray
cytogenetic biomonitoring
topic dental X-ray
cytogenetic biomonitoring
description Objectives: in the past decades, X-rays have been used widely for diagnosis in dentistry. However, it is well known that ionizing radiation causes damage (including single-and double-strand breaks) to deoxyribonucleic acid (DNA) and DNA-protein crosslinks, and induces cellular death. Therefore, outlining the cytogenetic effects induced by X-ray is necessary to identify the degree of cancer risk and minimize potential risks to patients and clinicians. To date, a variety of assays have been proposed in cytogenetic biomonitoring studies, including those that assess metaphase chromosomal aberrations and sister chromatid exchanges, and micronucleus and single-cell gel (comet) assay.Methods: Cytogenetic biomonitoring studies focusing on oral mucosa cells in individuals exposed to dental X-ray were reviewed.Results: Dental X-ray can induce DNA damage and cytotoxicity in oral mucosa cells.Conclusion: These results will contribute to a better understanding of X-ray-induced effects upon the cellular system in individuals continually exposed to known genotoxic/cytotoxic agents. Dentomaxillofacial Radiology (2012) 41, 181-184. doi: 10.1259/dmfr/14555883
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
2016-01-24T14:17:57Z
2016-01-24T14:17:57Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1259/dmfr/14555883
Dentomaxillofacial Radiology. London: British Inst Radiology, v. 41, n. 3, p. 181-184, 2012.
10.1259/dmfr/14555883
0250-832X
http://repositorio.unifesp.br/handle/11600/34648
WOS:000300930700001
url http://dx.doi.org/10.1259/dmfr/14555883
http://repositorio.unifesp.br/handle/11600/34648
identifier_str_mv Dentomaxillofacial Radiology. London: British Inst Radiology, v. 41, n. 3, p. 181-184, 2012.
10.1259/dmfr/14555883
0250-832X
WOS:000300930700001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dentomaxillofacial Radiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 181-184
dc.publisher.none.fl_str_mv British Inst Radiology
publisher.none.fl_str_mv British Inst Radiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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