Effect of zafirlukast on capsular contracture around silicone implants in rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/00130000056jn |
| DOI: | 10.1590/S0102-86502012000100001 |
| Texto Completo: | http://dx.doi.org/10.1590/S0102-86502012000100001 http://repositorio.unifesp.br/handle/11600/6810 |
Resumo: | PURPOSE: To evaluate the effect of zafirlukast on capsular contracture around silicone implants by measuring the pressure within the implant, using a rat experimental model. METHODS: Forty adult female Wistar rats were used. Each one received two silicone implants, one with smooth-surface and the other with textured-surface. They were randomly divided into four groups (n=10). The rats of control group I were sacrificed after the implants. The remaining animals were subjected to a daily regimen of intra-peritoneal injection for a period of 90 days and they were distributed as follows: control group II received 0.9% physiological saline solution; experimental group I received zafirlukast 1.25 mg/kg; and experimental group II received zafirlukast 5 mg/kg. The measurement of intra-implant pressure of control group I was determined on the surgery day and in other groups on the ninetieth day, after being sacrificed. RESULTS: In the evaluation of textured implants there was an increase of internal pressure in the control group II, and there was no increase in the experimental groups. Compared to the controls there were not significant differences in smooth implants. CONCLUSION: Zafirlukast reduced the risk of developing capsular contracture around silicone implants with textured surface. |
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Effect of zafirlukast on capsular contracture around silicone implants in ratsEfeito do zafirlukast na contratura capsular ao redor de implantes de silicone em ratosBreast ImplantsImplant Capsular ContractureLeukotriene AntagonistsRatsImplantes de MamaContratura Capsular em ImplantesAntagonistas de LeucotrienosRatosPURPOSE: To evaluate the effect of zafirlukast on capsular contracture around silicone implants by measuring the pressure within the implant, using a rat experimental model. METHODS: Forty adult female Wistar rats were used. Each one received two silicone implants, one with smooth-surface and the other with textured-surface. They were randomly divided into four groups (n=10). The rats of control group I were sacrificed after the implants. The remaining animals were subjected to a daily regimen of intra-peritoneal injection for a period of 90 days and they were distributed as follows: control group II received 0.9% physiological saline solution; experimental group I received zafirlukast 1.25 mg/kg; and experimental group II received zafirlukast 5 mg/kg. The measurement of intra-implant pressure of control group I was determined on the surgery day and in other groups on the ninetieth day, after being sacrificed. RESULTS: In the evaluation of textured implants there was an increase of internal pressure in the control group II, and there was no increase in the experimental groups. Compared to the controls there were not significant differences in smooth implants. CONCLUSION: Zafirlukast reduced the risk of developing capsular contracture around silicone implants with textured surface.OBJETIVO: Avaliar o efeito do zafirlukast na contratura capsular ao redor de implantes de silicone, através da aferição da pressão intra-implante, utilizando-se um modelo experimental de ratos. MÉTODOS: Quarenta ratos fêmeas Wistar foram utilizados. Cada um recebeu dois implantes de silicone, sendo um com superfície lisa e outro texturizada. Foram divididos aleatoriamente em quatro grupos (n=10). Os ratos do grupo controle I foram sacrificados após o implante. O restante dos animais foi submetido a um regime diário de injeção intraperitoneal por um período de 90 dias e foram distribuídos: grupo controle II recebeu solução salina fisiológica 0,9%, grupo experimental I recebeu zafirlukast 1,25 mg/kg, e grupo experimental II recebeu zafirlukast 5 mg/kg. O grupo controle II recebeu solução salina; grupo experimental I, 1,25 mg/kg/dia de zafirlukast; grupo experimental II, 5mg/kg/dia de zafirlukast. A aferição da pressão intra-implante do grupo controle I foi averiguada no dia do ato operatório, e nos outros grupos no nonagésimo dia, após serem sacrificados. RESULTADOS: Na avaliação dos implantes texturizados houve aumento da pressão interna no grupo controle II e, não se observou aumento nos grupos experimentais. Na comparação com os controles não foram observadas diferenças significativas nos implantes lisos. CONCLUSÃO: O Zafirlukast reduziu o risco de desenvolver contratura capsular em torno de implantes de silicone com superfície texturizada.University of MariliaUNIFESPUNIFESP, EPMSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversity of MariliaUniversidade Federal de São Paulo (UNIFESP)Bastos, Érika MalheirosSabino Neto, Miguel [UNIFESP]Garcia, Elvio Bueno [UNIFESP]Veiga, Daniela Francescato [UNIFESP]Han, Yuri AnnaDenadai, RafaelSantos, Rafael De AlmeidaFerreira, Lydia Masako [UNIFESP]2015-06-14T13:43:27Z2015-06-14T13:43:27Z2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion01-06application/pdfhttp://dx.doi.org/10.1590/S0102-86502012000100001Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 27, n. 1, p. 01-06, 2012.10.1590/S0102-86502012000100001S0102-86502012000100001.pdf0102-8650S0102-86502012000100001http://repositorio.unifesp.br/handle/11600/6810WOS:000298107000001ark:/48912/00130000056jnengActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T20:12:39Zoai:repositorio.unifesp.br/:11600/6810Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:58:17.068118Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Effect of zafirlukast on capsular contracture around silicone implants in rats Efeito do zafirlukast na contratura capsular ao redor de implantes de silicone em ratos |
| title |
Effect of zafirlukast on capsular contracture around silicone implants in rats |
| spellingShingle |
Effect of zafirlukast on capsular contracture around silicone implants in rats Effect of zafirlukast on capsular contracture around silicone implants in rats Bastos, Érika Malheiros Breast Implants Implant Capsular Contracture Leukotriene Antagonists Rats Implantes de Mama Contratura Capsular em Implantes Antagonistas de Leucotrienos Ratos Bastos, Érika Malheiros Breast Implants Implant Capsular Contracture Leukotriene Antagonists Rats Implantes de Mama Contratura Capsular em Implantes Antagonistas de Leucotrienos Ratos |
| title_short |
Effect of zafirlukast on capsular contracture around silicone implants in rats |
| title_full |
Effect of zafirlukast on capsular contracture around silicone implants in rats |
| title_fullStr |
Effect of zafirlukast on capsular contracture around silicone implants in rats Effect of zafirlukast on capsular contracture around silicone implants in rats |
| title_full_unstemmed |
Effect of zafirlukast on capsular contracture around silicone implants in rats Effect of zafirlukast on capsular contracture around silicone implants in rats |
| title_sort |
Effect of zafirlukast on capsular contracture around silicone implants in rats |
| author |
Bastos, Érika Malheiros |
| author_facet |
Bastos, Érika Malheiros Bastos, Érika Malheiros Sabino Neto, Miguel [UNIFESP] Garcia, Elvio Bueno [UNIFESP] Veiga, Daniela Francescato [UNIFESP] Han, Yuri Anna Denadai, Rafael Santos, Rafael De Almeida Ferreira, Lydia Masako [UNIFESP] Sabino Neto, Miguel [UNIFESP] Garcia, Elvio Bueno [UNIFESP] Veiga, Daniela Francescato [UNIFESP] Han, Yuri Anna Denadai, Rafael Santos, Rafael De Almeida Ferreira, Lydia Masako [UNIFESP] |
| author_role |
author |
| author2 |
Sabino Neto, Miguel [UNIFESP] Garcia, Elvio Bueno [UNIFESP] Veiga, Daniela Francescato [UNIFESP] Han, Yuri Anna Denadai, Rafael Santos, Rafael De Almeida Ferreira, Lydia Masako [UNIFESP] |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
University of Marilia Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Bastos, Érika Malheiros Sabino Neto, Miguel [UNIFESP] Garcia, Elvio Bueno [UNIFESP] Veiga, Daniela Francescato [UNIFESP] Han, Yuri Anna Denadai, Rafael Santos, Rafael De Almeida Ferreira, Lydia Masako [UNIFESP] |
| dc.subject.por.fl_str_mv |
Breast Implants Implant Capsular Contracture Leukotriene Antagonists Rats Implantes de Mama Contratura Capsular em Implantes Antagonistas de Leucotrienos Ratos |
| topic |
Breast Implants Implant Capsular Contracture Leukotriene Antagonists Rats Implantes de Mama Contratura Capsular em Implantes Antagonistas de Leucotrienos Ratos |
| description |
PURPOSE: To evaluate the effect of zafirlukast on capsular contracture around silicone implants by measuring the pressure within the implant, using a rat experimental model. METHODS: Forty adult female Wistar rats were used. Each one received two silicone implants, one with smooth-surface and the other with textured-surface. They were randomly divided into four groups (n=10). The rats of control group I were sacrificed after the implants. The remaining animals were subjected to a daily regimen of intra-peritoneal injection for a period of 90 days and they were distributed as follows: control group II received 0.9% physiological saline solution; experimental group I received zafirlukast 1.25 mg/kg; and experimental group II received zafirlukast 5 mg/kg. The measurement of intra-implant pressure of control group I was determined on the surgery day and in other groups on the ninetieth day, after being sacrificed. RESULTS: In the evaluation of textured implants there was an increase of internal pressure in the control group II, and there was no increase in the experimental groups. Compared to the controls there were not significant differences in smooth implants. CONCLUSION: Zafirlukast reduced the risk of developing capsular contracture around silicone implants with textured surface. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-01-01 2015-06-14T13:43:27Z 2015-06-14T13:43:27Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502012000100001 Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 27, n. 1, p. 01-06, 2012. 10.1590/S0102-86502012000100001 S0102-86502012000100001.pdf 0102-8650 S0102-86502012000100001 http://repositorio.unifesp.br/handle/11600/6810 WOS:000298107000001 |
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ark:/48912/00130000056jn |
| url |
http://dx.doi.org/10.1590/S0102-86502012000100001 http://repositorio.unifesp.br/handle/11600/6810 |
| identifier_str_mv |
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 27, n. 1, p. 01-06, 2012. 10.1590/S0102-86502012000100001 S0102-86502012000100001.pdf 0102-8650 S0102-86502012000100001 WOS:000298107000001 ark:/48912/00130000056jn |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
01-06 application/pdf |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
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UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1822183950103085056 |
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10.1590/S0102-86502012000100001 |