An Overview of B-1 Cells as Antigen-Presenting Cells

• Autor(a) principal: Popi, Ana Flavia [UNIFESP]
• Data de Publicação: 2016
• Outros Autores: Longo-Maugéri, Ieda Maria [UNIFESP], Mariano, Mario [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.3389/fimmu.2016.00138; https://repositorio.unifesp.br/handle/11600/56054
• topic: B-1 cells; APCs; BCR; TLR; autoimmune diseases

The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as APCs is beginning to be explored. Initially, it was described that B-1 cells are activated preferentially by T-independent antigens. However, some reports demonstrated that these cells are also involved in a T-dependent response. The aim of this review is to summarize information about the ability of B-1 cells to play a role as APCs and to briefly discuss the role of the BCR and toll-like receptor signals in this process. Furthermore, some characteristics of B-1 cells, such as natural IgM production and phagocytic ability, could interfere in the participation of these cells in the onset of an adaptive response.