Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.3892/ol.2017.5817 https://repositorio.unifesp.br/handle/11600/54607 |
Resumo: | The replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%). FNA had a sensitivity of 45%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 73%. Axillary lymph node cytology obtained by US guided-FNA in patients with breast cancer had a specificity similar to that of sentinel lymph node histopathology in the presence of axillary node metastases. However, when lymph node cytology is negative, it does not exclude the existence of metastatic implants, due to its low sensitivity in comparison to sentinel lymph node histopathology. |
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Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancerbreast canceraxillary lymph nodesentinel lymph nodefine-needle aspiration biopsyThe replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%). FNA had a sensitivity of 45%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 73%. Axillary lymph node cytology obtained by US guided-FNA in patients with breast cancer had a specificity similar to that of sentinel lymph node histopathology in the presence of axillary node metastases. However, when lymph node cytology is negative, it does not exclude the existence of metastatic implants, due to its low sensitivity in comparison to sentinel lymph node histopathology.Univ Fed Piaui, Postgrad Sci & Hlth Program, 2280 Ave Frei Serafim, BR-64001020 Teresina, PI, BrazilGetulio Vargas Hosp, Breast Disorder Unit, 2280 Ave Frei Serafim, BR-64001020 Teresina, PI, BrazilUniv Sao Paulo, Dept Stat, BR-05508220 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Mastol, BR-04024002 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Mastol, BR-04024002 Sao Paulo, SP, BrazilWeb of ScienceSpandidos Publ Ltd2020-07-13T11:53:25Z2020-07-13T11:53:25Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion3299-3302http://dx.doi.org/10.3892/ol.2017.5817Oncology Letters. Athens, v. 13, n. 5, p. 3299-3302, 2017.10.3892/ol.2017.58171792-1074https://repositorio.unifesp.br/handle/11600/54607WOS:000401129800062engOncology LettersAthensinfo:eu-repo/semantics/openAccessCardoso-Coelho, Livio PortelaBorges, Rafael SoaresAlencar, Airlane PereiraCardoso-Campos-Verdes, Larysse Mairada Silva-Sampai, Joao PauloBorges, Umbelina SoaresGebrim, Luiz Henrique [UNIFESP]da Silva, Benedito Borgesreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-10-05T22:05:36Zoai:repositorio.unifesp.br/:11600/54607Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-10-05T22:05:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer |
| title |
Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer |
| spellingShingle |
Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer Cardoso-Coelho, Livio Portela breast cancer axillary lymph node sentinel lymph node fine-needle aspiration biopsy |
| title_short |
Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer |
| title_full |
Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer |
| title_fullStr |
Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer |
| title_full_unstemmed |
Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer |
| title_sort |
Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer |
| author |
Cardoso-Coelho, Livio Portela |
| author_facet |
Cardoso-Coelho, Livio Portela Borges, Rafael Soares Alencar, Airlane Pereira Cardoso-Campos-Verdes, Larysse Maira da Silva-Sampai, Joao Paulo Borges, Umbelina Soares Gebrim, Luiz Henrique [UNIFESP] da Silva, Benedito Borges |
| author_role |
author |
| author2 |
Borges, Rafael Soares Alencar, Airlane Pereira Cardoso-Campos-Verdes, Larysse Maira da Silva-Sampai, Joao Paulo Borges, Umbelina Soares Gebrim, Luiz Henrique [UNIFESP] da Silva, Benedito Borges |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cardoso-Coelho, Livio Portela Borges, Rafael Soares Alencar, Airlane Pereira Cardoso-Campos-Verdes, Larysse Maira da Silva-Sampai, Joao Paulo Borges, Umbelina Soares Gebrim, Luiz Henrique [UNIFESP] da Silva, Benedito Borges |
| dc.subject.por.fl_str_mv |
breast cancer axillary lymph node sentinel lymph node fine-needle aspiration biopsy |
| topic |
breast cancer axillary lymph node sentinel lymph node fine-needle aspiration biopsy |
| description |
The replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%). FNA had a sensitivity of 45%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 73%. Axillary lymph node cytology obtained by US guided-FNA in patients with breast cancer had a specificity similar to that of sentinel lymph node histopathology in the presence of axillary node metastases. However, when lymph node cytology is negative, it does not exclude the existence of metastatic implants, due to its low sensitivity in comparison to sentinel lymph node histopathology. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2020-07-13T11:53:25Z 2020-07-13T11:53:25Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3892/ol.2017.5817 Oncology Letters. Athens, v. 13, n. 5, p. 3299-3302, 2017. 10.3892/ol.2017.5817 1792-1074 https://repositorio.unifesp.br/handle/11600/54607 WOS:000401129800062 |
| url |
http://dx.doi.org/10.3892/ol.2017.5817 https://repositorio.unifesp.br/handle/11600/54607 |
| identifier_str_mv |
Oncology Letters. Athens, v. 13, n. 5, p. 3299-3302, 2017. 10.3892/ol.2017.5817 1792-1074 WOS:000401129800062 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Oncology Letters |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
3299-3302 |
| dc.coverage.none.fl_str_mv |
Athens |
| dc.publisher.none.fl_str_mv |
Spandidos Publ Ltd |
| publisher.none.fl_str_mv |
Spandidos Publ Ltd |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268454819069952 |