Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center

Detalhes bibliográficos
Autor(a) principal: Nascimento, Heloisa [UNIFESP]
Data de Publicação: 2018
Outros Autores: Sousa, Jacqueline M. [UNIFESP], Fernandez, Delia Gonzalez [UNIFESP], Salomao, Gustavo H. A. [UNIFESP], Sato, Elcio H. [UNIFESP], Muccioli, Cristina [UNIFESP], Belfort, Rubens, Jr. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.3928/23258160-20171215-12
https://repositorio.unifesp.br/handle/11600/53925
Resumo: In a prospective case series of patients with Blau-Jabs syndrome (BJS) conducted in the Ophthalmology Department/Federal University of Sao Paulo, seven patients math clinical and ophthalmologic manifestations of the disease and a positive genetic test result for the presence of a mutation in the CARD15/NOD2 gene were followed for a minimal period of 1 year. All patients had uveitis, five had nummular corneal subepithelial opacities, and four had multifocal choroiditis. Oral prednisolone was administered to all patients
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spelling Blau-Jabs Syndrome in a Tertiary Ophthalmologic CenterIn a prospective case series of patients with Blau-Jabs syndrome (BJS) conducted in the Ophthalmology Department/Federal University of Sao Paulo, seven patients math clinical and ophthalmologic manifestations of the disease and a positive genetic test result for the presence of a mutation in the CARD15/NOD2 gene were followed for a minimal period of 1 year. All patients had uveitis, five had nummular corneal subepithelial opacities, and four had multifocal choroiditis. Oral prednisolone was administered to all patientsinflammation was controlled in six patients with at least one immunosuppressive drug. Infliximab (RemicadeJanssen Pharmaceuticals, Beerse, Belgium) and etanercept (EnbrelAmgen, Thousand Oaks, CA) were used to treat two cases refractory to the antiinflammatory drugs. A subconjunctival dexamethasone implant (OzurdexAllergan, Irvine, CA) and a periocular injection of triamcinolone were used in one case to achieve inflammation control. Six patients achieved a visual acuity of 20/25 or better. The authors conclude that periocular treatment with steroid injections might be effective adjuvant therapy to control ocular inflammation.Univ Fed Sao Paulo, UNIFESP Escola Paulista Med Brazil, Dept Ophthalmol, Sao Paulo, BrazilUniv Fed Sao Paulo, UNIFESP Escola Paulista Med Brazil, Dept Ophthalmol, Sao Paulo, BrazilWeb of ScienceSlack Inc2020-07-02T18:52:11Z2020-07-02T18:52:11Z2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion70-75application/pdfhttp://dx.doi.org/10.3928/23258160-20171215-12Ophthalmic Surgery Lasers & Imaging Retina. Thorofare, v. 49, n. 1, p. 70-75, 2018.10.3928/23258160-20171215-12WOS000419990200012.pdf2325-8160https://repositorio.unifesp.br/handle/11600/53925WOS:000419990200012engOphthalmic Surgery Lasers & Imaging RetinaThorofareinfo:eu-repo/semantics/openAccessNascimento, Heloisa [UNIFESP]Sousa, Jacqueline M. [UNIFESP]Fernandez, Delia Gonzalez [UNIFESP]Salomao, Gustavo H. A. [UNIFESP]Sato, Elcio H. [UNIFESP]Muccioli, Cristina [UNIFESP]Belfort, Rubens, Jr. [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T05:16:54Zoai:repositorio.unifesp.br/:11600/53925Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T05:16:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center
title Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center
spellingShingle Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center
Nascimento, Heloisa [UNIFESP]
title_short Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center
title_full Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center
title_fullStr Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center
title_full_unstemmed Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center
title_sort Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center
author Nascimento, Heloisa [UNIFESP]
author_facet Nascimento, Heloisa [UNIFESP]
Sousa, Jacqueline M. [UNIFESP]
Fernandez, Delia Gonzalez [UNIFESP]
Salomao, Gustavo H. A. [UNIFESP]
Sato, Elcio H. [UNIFESP]
Muccioli, Cristina [UNIFESP]
Belfort, Rubens, Jr. [UNIFESP]
author_role author
author2 Sousa, Jacqueline M. [UNIFESP]
Fernandez, Delia Gonzalez [UNIFESP]
Salomao, Gustavo H. A. [UNIFESP]
Sato, Elcio H. [UNIFESP]
Muccioli, Cristina [UNIFESP]
Belfort, Rubens, Jr. [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, Heloisa [UNIFESP]
Sousa, Jacqueline M. [UNIFESP]
Fernandez, Delia Gonzalez [UNIFESP]
Salomao, Gustavo H. A. [UNIFESP]
Sato, Elcio H. [UNIFESP]
Muccioli, Cristina [UNIFESP]
Belfort, Rubens, Jr. [UNIFESP]
description In a prospective case series of patients with Blau-Jabs syndrome (BJS) conducted in the Ophthalmology Department/Federal University of Sao Paulo, seven patients math clinical and ophthalmologic manifestations of the disease and a positive genetic test result for the presence of a mutation in the CARD15/NOD2 gene were followed for a minimal period of 1 year. All patients had uveitis, five had nummular corneal subepithelial opacities, and four had multifocal choroiditis. Oral prednisolone was administered to all patients
publishDate 2018
dc.date.none.fl_str_mv 2018
2020-07-02T18:52:11Z
2020-07-02T18:52:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3928/23258160-20171215-12
Ophthalmic Surgery Lasers & Imaging Retina. Thorofare, v. 49, n. 1, p. 70-75, 2018.
10.3928/23258160-20171215-12
WOS000419990200012.pdf
2325-8160
https://repositorio.unifesp.br/handle/11600/53925
WOS:000419990200012
url http://dx.doi.org/10.3928/23258160-20171215-12
https://repositorio.unifesp.br/handle/11600/53925
identifier_str_mv Ophthalmic Surgery Lasers & Imaging Retina. Thorofare, v. 49, n. 1, p. 70-75, 2018.
10.3928/23258160-20171215-12
WOS000419990200012.pdf
2325-8160
WOS:000419990200012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ophthalmic Surgery Lasers & Imaging Retina
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 70-75
application/pdf
dc.coverage.none.fl_str_mv Thorofare
dc.publisher.none.fl_str_mv Slack Inc
publisher.none.fl_str_mv Slack Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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