Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/57396 https://dx.doi.org/10.1590/1516-3180.2016.0358280417 |
Resumo: | BACKGROUND: Insulin resistance (IR) and progressive pancreatic beta-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in nondiabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND SETTING: Cross-sectional study conducted in a private clinic. METHODS: We included obese individuals (body mass index, BMI >= 30 kg/m(2)) with no diabetes mellitus (fasting glucose levels <= 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-beta indexes. The area under the curve (AUC) of the variables was compared. The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated. RESULTS: The most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-beta and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-beta, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73). The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-beta. CONCLUSION: Among anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals. |
id |
UFSP_ebec77b3655f472b88c13be84e15797c |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/57396 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Jamar, Giovana [UNIFESP]Almeida, Flavio Rossi de [UNIFESP]Gagliardi, Antonio Ricardo de Toledo [UNIFESP]Sobral, Marianna Ribeiro [UNIFESP]Ping, Chao Tsai [UNIFESP]Sperandio, Evandro Fornias [UNIFESP]Romiti, Marcello [UNIFESP]Arantes, Rodolfo Leite [UNIFESP]Dourado, Victor Zuniga [UNIFESP]2020-08-04T13:40:15Z2020-08-04T13:40:15Z2017Sao Paulo Medical Journal. Sao Paulo, v. 135, n. 5, p. 462-468, 2017.1516-3180https://repositorio.unifesp.br/handle/11600/57396https://dx.doi.org/10.1590/1516-3180.2016.0358280417S1516-31802017000500462.pdfS1516-3180201700050046210.1590/1516-3180.2016.0358280417WOS:000417223700008BACKGROUND: Insulin resistance (IR) and progressive pancreatic beta-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in nondiabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND SETTING: Cross-sectional study conducted in a private clinic. METHODS: We included obese individuals (body mass index, BMI >= 30 kg/m(2)) with no diabetes mellitus (fasting glucose levels <= 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-beta indexes. The area under the curve (AUC) of the variables was compared. The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated. RESULTS: The most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-beta and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-beta, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73). The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-beta. CONCLUSION: Among anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Paulo Unifesp, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Biosci, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Biosci, Dept Human Movement Sci, Sao Paulo, SP, BrazilAngiocorpore Inst Med Cardiovasc, Dept Cardiovasc Med, Sao Paulo, SP, BrazilFed Univ Sao Paulo Unifesp, Postgrad Program Food Nutr & Hlth, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Lab Epidemiol & Human Movement, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Human Movement Sci, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Biosci, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Biosci, Dept Human Movement Sci, Sao Paulo, SP, BrazilFed Univ Sao Paulo Unifesp, Postgrad Program Food Nutr & Hlth, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Lab Epidemiol & Human Movement, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Human Movement Sci, Sao Paulo, SP, BrazilFAPESP: 2011/07282-6Web of Science462-468engAssociação Paulista MedicinaSao Paulo Medical JournalAnthropometryObesityDiabetes mellitusEvaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo1355info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1516-31802017000500462.pdfapplication/pdf217737${dspace.ui.url}/bitstream/11600/57396/1/S1516-31802017000500462.pdfe1657ddd9bd27634ca32fb44290be5f6MD51open accessTEXTS1516-31802017000500462.pdf.txtS1516-31802017000500462.pdf.txtExtracted texttext/plain34976${dspace.ui.url}/bitstream/11600/57396/5/S1516-31802017000500462.pdf.txtf9909bfd3e15c566dc7aee7670361e0dMD55open accessTHUMBNAILS1516-31802017000500462.pdf.jpgS1516-31802017000500462.pdf.jpgIM Thumbnailimage/jpeg6549${dspace.ui.url}/bitstream/11600/57396/7/S1516-31802017000500462.pdf.jpgf994c3c0bd3f36abef4af26eae145f0dMD57open access11600/573962023-06-05 19:07:51.791open accessoai:repositorio.unifesp.br:11600/57396Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:07:51Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study |
title |
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study |
spellingShingle |
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study Jamar, Giovana [UNIFESP] Anthropometry Obesity Diabetes mellitus |
title_short |
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study |
title_full |
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study |
title_fullStr |
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study |
title_full_unstemmed |
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study |
title_sort |
Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study |
author |
Jamar, Giovana [UNIFESP] |
author_facet |
Jamar, Giovana [UNIFESP] Almeida, Flavio Rossi de [UNIFESP] Gagliardi, Antonio Ricardo de Toledo [UNIFESP] Sobral, Marianna Ribeiro [UNIFESP] Ping, Chao Tsai [UNIFESP] Sperandio, Evandro Fornias [UNIFESP] Romiti, Marcello [UNIFESP] Arantes, Rodolfo Leite [UNIFESP] Dourado, Victor Zuniga [UNIFESP] |
author_role |
author |
author2 |
Almeida, Flavio Rossi de [UNIFESP] Gagliardi, Antonio Ricardo de Toledo [UNIFESP] Sobral, Marianna Ribeiro [UNIFESP] Ping, Chao Tsai [UNIFESP] Sperandio, Evandro Fornias [UNIFESP] Romiti, Marcello [UNIFESP] Arantes, Rodolfo Leite [UNIFESP] Dourado, Victor Zuniga [UNIFESP] |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Jamar, Giovana [UNIFESP] Almeida, Flavio Rossi de [UNIFESP] Gagliardi, Antonio Ricardo de Toledo [UNIFESP] Sobral, Marianna Ribeiro [UNIFESP] Ping, Chao Tsai [UNIFESP] Sperandio, Evandro Fornias [UNIFESP] Romiti, Marcello [UNIFESP] Arantes, Rodolfo Leite [UNIFESP] Dourado, Victor Zuniga [UNIFESP] |
dc.subject.eng.fl_str_mv |
Anthropometry Obesity Diabetes mellitus |
topic |
Anthropometry Obesity Diabetes mellitus |
description |
BACKGROUND: Insulin resistance (IR) and progressive pancreatic beta-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in nondiabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND SETTING: Cross-sectional study conducted in a private clinic. METHODS: We included obese individuals (body mass index, BMI >= 30 kg/m(2)) with no diabetes mellitus (fasting glucose levels <= 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-beta indexes. The area under the curve (AUC) of the variables was compared. The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated. RESULTS: The most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-beta and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-beta, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73). The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-beta. CONCLUSION: Among anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-08-04T13:40:15Z |
dc.date.available.fl_str_mv |
2020-08-04T13:40:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Sao Paulo Medical Journal. Sao Paulo, v. 135, n. 5, p. 462-468, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/57396 https://dx.doi.org/10.1590/1516-3180.2016.0358280417 |
dc.identifier.issn.none.fl_str_mv |
1516-3180 |
dc.identifier.file.none.fl_str_mv |
S1516-31802017000500462.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1516-31802017000500462 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1516-3180.2016.0358280417 |
dc.identifier.wos.none.fl_str_mv |
WOS:000417223700008 |
identifier_str_mv |
Sao Paulo Medical Journal. Sao Paulo, v. 135, n. 5, p. 462-468, 2017. 1516-3180 S1516-31802017000500462.pdf S1516-31802017000500462 10.1590/1516-3180.2016.0358280417 WOS:000417223700008 |
url |
https://repositorio.unifesp.br/handle/11600/57396 https://dx.doi.org/10.1590/1516-3180.2016.0358280417 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Sao Paulo Medical Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
462-468 |
dc.coverage.none.fl_str_mv |
Sao Paulo |
dc.publisher.none.fl_str_mv |
Associação Paulista Medicina |
publisher.none.fl_str_mv |
Associação Paulista Medicina |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/57396/1/S1516-31802017000500462.pdf ${dspace.ui.url}/bitstream/11600/57396/5/S1516-31802017000500462.pdf.txt ${dspace.ui.url}/bitstream/11600/57396/7/S1516-31802017000500462.pdf.jpg |
bitstream.checksum.fl_str_mv |
e1657ddd9bd27634ca32fb44290be5f6 f9909bfd3e15c566dc7aee7670361e0d f994c3c0bd3f36abef4af26eae145f0d |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764145587650560 |